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AT2G34650.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
plasma membrane 1.000
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : Protein kinase superfamily protein
Curator
Summary (TAIR10)
Encodes a protein serine/threonine kinase that may act as a positive regulator of cellular auxin efflux, as a a binary switch for PIN polarity, and as a negative regulator of auxin signaling. Recessive mutants exhibit similar phenotypes as pin-formed mutants in flowers and inflorescence but distinct phenotypes in cotyledons and leaves. Expressed in the vascular tissue proximal to root and shoot meristems, shoot apex, and embryos. Expression is induced by auxin. Overexpression of the gene results in phenotypes in the root and shoot similar to those found in auxin-insensitive mutants. The protein physically interacts with TCH3 (TOUCH3) and PID-BINDING PROTEIN 1 (PBP1), a previously uncharacterized protein containing putative EF-hand calcium-binding motifs. Acts together with ENP (ENHANCER OF PINOID) to instruct precursor cells to elaborate cotyledons in the transition stage embryo. Interacts with PDK1. PID autophosphorylation is required for the ability of PID to phosphorylate an exogenous substrate. PID activation loop is required for PDK1-dependent PID phosphorylation and requires the PIF domain. Negative regulator of root hair growth. PID kinase activity is critical for the inhibition of root hair growth and for maintaining the proper subcellular localization of PID.
Computational
Description (TAIR10)
PINOID (PID); CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: D6 protein kinase (TAIR:AT5G55910.1); Has 93882 Blast hits to 91860 proteins in 2892 species: Archae - 58; Bacteria - 12658; Metazoa - 35611; Fungi - 11097; Plants - 17324; Viruses - 331; Other Eukaryotes - 16803 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT2G34650-MONOMERBioGrid:3376DIP:DIP-39595NEC:2.7.11.1eggNOG:ENOG410XQ0CeggNOG:KOG0610EMBL:AC004077
EMBL:AF232236EMBL:CP002685EnsemblPlants:AT2G34650EnsemblPlants:AT2G34650.1entrez:818030GeneID:818030Genevisible:O64682
GO:GO:0004672GO:GO:0004674GO:GO:0005524GO:GO:0005737GO:GO:0005829GO:GO:0005886GO:GO:0009733
GO:GO:0009734GO:GO:0009926GO:GO:0009958GO:GO:0009986GO:GO:0016301GO:GO:0035556GO:GO:0048766
GO:GO:0048767GO:GO:0048825GO:GO:0048827GO:GO:0080167Gramene:AT2G34650.1hmmpanther:PTHR24351hmmpanther:PTHR24351:SF60
HOGENOM:HOG000233027InParanoid:O64682IntAct:O64682InterPro:IPR000719InterPro:IPR008271InterPro:IPR011009KEGG:ath:AT2G34650
ncoils:CoilOMA:MSLGTTNPaxDb:O64682Pfam:O64682Pfam:PF00069Pfscan:PS50011PhylomeDB:O64682
PIR:C84759PRIDE:O64682PRO:PR:O64682PROSITE:PS00108PROSITE:PS50011ProteinModelPortal:O64682Proteomes:UP000006548
RefSeq:NP_181012.1scanprosite:PS00108SMART:SM00220SMR:O64682STRING:3702.AT2G34650.1SUPFAM:SSF56112TAIR:AT2G34650
tair10-symbols:ABRtair10-symbols:PIDUniGene:At.19528UniProt:O64682
Coordinates (TAIR10) chr2:-:14589934..14591557
Molecular Weight (calculated) 49274.20 Da
IEP (calculated) 9.81
GRAVY (calculated) -0.28
Length 438 amino acids
Sequence (TAIR10)
(BLAST)
001: MLRESDGEMS LGTTNSPISS GTESCSSFSR LSFDAPPSTI PEEESFLSLK PHRSSDFAYA EIRRRKKQGL TFRDFRLMRR IGAGDIGTVY LCRLAGDEEE
101: SRSSYFAMKV VDKEALALKK KMHRAEMEKT ILKMLDHPFL PTLYAEFEAS HFSCIVMEYC SGGDLHSLRH RQPHRRFSLS SARFYAAEVL VALEYLHMLG
201: IIYRDLKPEN ILVRSDGHIM LSDFDLSLCS DSIAAVESSS SSPENQQLRS PRRFTRLARL FQRVLRSKKV QTLEPTRLFV AEPVTARSGS FVGTHEYVAP
301: EVASGGSHGN AVDWWAFGVF LYEMIYGKTP FVAPTNDVIL RNIVKRQLSF PTDSPATMFE LHARNLISGL LNKDPTKRLG SRRGAAEVKV HPFFKGLNFA
401: LIRTLTPPEI PSSVVKKPMK SATFSGRSSN KPAAFDYF
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)