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AT4G23100.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
plastid 1.000
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : glutamate-cysteine ligase
Curator
Summary (TAIR10)
Encodes the enzyme glutamate-cysteine ligase catalyzing the first, and rate-limiting, step of glutathione biosynthesis. Required for cell proliferation at the root tip. Involved in susceptibility to the bacterial pathogen Pseudomonas syringae. Mutants are phytoalexin defective.
Computational
Description (TAIR10)
glutamate-cysteine ligase (GSH1); FUNCTIONS IN: glutamate-cysteine ligase activity; INVOLVED IN: in 13 processes; LOCATED IN: chloroplast stroma, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Glutamate--cysteine ligase, GCS2 (InterPro:IPR006336), Glutamate--cysteine ligase, plant (InterPro:IPR011556); Has 2650 Blast hits to 2650 proteins in 482 species: Archae - 15; Bacteria - 892; Metazoa - 0; Fungi - 0; Plants - 118; Viruses - 0; Other Eukaryotes - 1625 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT4G23100-MONOMERBioCyc:ARA:GQT-894-MONOMERBioCyc:ARA:GQT-895-MONOMERBioCyc:MetaCyc:AT4G23100-MONOMERBioGrid:13698BRENDA:6.3.2.2EC:6.3.2.2
eggNOG:COG3572eggNOG:ENOG410IK1FEMBL:AF068299EMBL:AF419576EMBL:AF428393EMBL:AL031018EMBL:AL161558
EMBL:AY056372EMBL:AY143970EMBL:CP002687EMBL:DQ993178EMBL:Y09944EMBL:Z29490EnsemblPlants:AT4G23100
EnsemblPlants:AT4G23100.1EnsemblPlants:AT4G23100.3entrez:828409ExpressionAtlas:P46309GeneID:828409Genevisible:P46309GO:GO:0002213
GO:GO:0004357GO:GO:0005524GO:GO:0006750GO:GO:0009408GO:GO:0009507GO:GO:0009536GO:GO:0009570
GO:GO:0009700GO:GO:0009753GO:GO:0009816GO:GO:0009908GO:GO:0010193GO:GO:0019761GO:GO:0042742
GO:GO:0046686GO:GO:0050832GO:GO:0052544gramene_pathway:6.3.2.2gramene_pathway:GLUTATHIONESYN-PWYgramene_pathway:PWYQT-4470gramene_plant_reactome:1119342
gramene_plant_reactome:6875249hmmpanther:PTHR34378hmmpanther:PTHR34378:SF1HOGENOM:HOG000009857InParanoid:P46309InterPro:IPR006336InterPro:IPR011556
KEGG:00270+6.3.2.2KEGG:00480+6.3.2.2OMA:DYVEWALPaxDb:P46309Pfam:P46309Pfam:PF04107PhylomeDB:P46309
PIR:T05142PRIDE:P46309PRO:PR:P46309ProteinModelPortal:P46309Proteomes:UP000006548RefSeq:NP_001190808.1RefSeq:NP_194041.1
SABIO-RK:P46309SMR:P46309STRING:3702.AT4G23100.1SUPFAM:SSF55931TAIR:AT4G23100tair10-symbols:ATECS1tair10-symbols:CAD2
tair10-symbols:GSH1tair10-symbols:GSHAtair10-symbols:PAD2tair10-symbols:RML1TIGRfam:TIGR01436TIGRFAMs:TIGR01436UniGene:At.25074
UniPathway:UPA00142UniProt:P46309
Coordinates (TAIR10) chr4:-:12103458..12106751
Molecular Weight (calculated) 58565.70 Da
IEP (calculated) 6.53
GRAVY (calculated) -0.26
Length 522 amino acids
Sequence (TAIR10)
(BLAST)
001: MALLSQAGGS YTVVPSGVCS KAGTKAVVSG GVRNLDVLRM KEAFGSSYSR SLSTKSMLLH SVKRSKRGHQ LIVAASPPTE EAVVATEPLT REDLIAYLAS
101: GCKTKDKYRI GTEHEKFGFE VNTLRPMKYD QIAELLNGIA ERFEWEKVME GDKIIGLKQG KQSISLEPGG QFELSGAPLE TLHQTCAEVN SHLYQVKAVA
201: EEMGIGFLGI GFQPKWRRED IPIMPKGRYD IMRNYMPKVG TLGLDMMLRT CTVQVNLDFS SEADMIRKFR AGLALQPIAT ALFANSPFTE GKPNGFLSMR
301: SHIWTDTDKD RTGMLPFVFD DSFGFEQYVD YALDVPMYFA YRKNKYIDCT GMTFRQFLAG KLPCLPGELP SYNDWENHLT TIFPEVRLKR YLEMRGADGG
401: PWRRLCALPA FWVGLLYDDD SLQAILDLTA DWTPAEREML RNKVPVTGLK TPFRDGLLKH VAEDVLKLAK DGLERRGYKE AGFLNAVDEV VRTGVTPAEK
501: LLEMYNGEWG QSVDPVFEEL LY
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)