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AT5G67100.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
nucleus 1.000
ASURE: nucleus
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : DNA-directed DNA polymerases
Curator
Summary (TAIR10)
Encodes the putative catalytic subunit of the DNA polymerase alpha. Interacts with genes involved in chromatin-mediated cellular memory. ICU2 genetically interacts with TERMINAL FLOWER2, the ortholog of HETEROCHROMATIN PROTEIN1 of animals and yeasts, and with the Polycomb group (PcG) gene CURLY LEAF. A number of regulatory genes were derepressed in the icu2-1 mutant, including genes associated with flowering time, floral meristem, and floral organ identity. Mutant has curled, involute leaves and causes early flowering.
Computational
Description (TAIR10)
INCURVATA2 (ICU2); FUNCTIONS IN: DNA-directed DNA polymerase activity; INVOLVED IN: negative regulation of flower development, leaf morphogenesis; LOCATED IN: nucleus; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA polymerase, family B (InterPro:IPR022762), DNA-directed DNA polymerase, family B, exonuclease domain (InterPro:IPR006133), DNA-directed DNA polymerase, family B, conserved region (InterPro:IPR006134), Zinc finger, DNA-directed DNA polymerase, family B, alpha (InterPro:IPR015088), Polynucleotidyl transferase, ribonuclease H fold (InterPro:IPR012337), DNA-directed DNA polymerase, family B, conserved site (InterPro:IPR017964), DNA-directed DNA polymerase, family B (InterPro:IPR006172), DNA-directed DNA polymerase, family B, pol2 (InterPro:IPR004578); BEST Arabidopsis thaliana protein match is: DNA binding;nucleotide binding;nucleic acid binding;DNA-directed DNA polymerases;DNA-directed DNA polymerases (TAIR:AT5G63960.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT5G67100-MONOMERBioGrid:22087EC:2.7.7.7eggNOG:COG0417eggNOG:KOG0970EMBL:AB020742EMBL:CP002688
EnsemblPlants:AT5G67100EnsemblPlants:AT5G67100.1entrez:836845Gene3D:3.30.420.10Gene3D:3.90.1600.10GeneID:836845Genevisible:Q9FHA3
GO:GO:0000166GO:GO:0001882GO:GO:0003677GO:GO:0003887GO:GO:0005634GO:GO:0006270GO:GO:0008408
GO:GO:0046872GO:GO:0051539Gramene:AT5G67100.1hmmpanther:PTHR10322hmmpanther:PTHR10322:SF21InParanoid:Q9FHA3InterPro:IPR006133
InterPro:IPR006134InterPro:IPR006172InterPro:IPR012337InterPro:IPR015088InterPro:IPR017964InterPro:IPR023211InterPro:IPR024647
InterPro:IPR029702KEGG:00230+2.7.7.7KEGG:00240+2.7.7.7KEGG:ath:AT5G67100KO:K02320ncoils:CoilOMA:RLMCELN
PANTHER:PTHR10322:SF21PaxDb:Q9FHA3Pfam:PF00136Pfam:PF03104Pfam:PF08996Pfam:PF12254Pfam:Q9FHA3
PRIDE:Q9FHA3PRINTS:PR00106PRO:PR:Q9FHA3PROSITE:PS00116ProteinModelPortal:Q9FHA3Proteomes:UP000006548Reactome:R-ATH-113501
Reactome:R-ATH-113510Reactome:R-ATH-174411Reactome:R-ATH-174430Reactome:R-ATH-68952Reactome:R-ATH-68962Reactome:R-ATH-69091Reactome:R-ATH-69109
Reactome:R-ATH-69166Reactome:R-ATH-69183Reactome:R-ATH-69205RefSeq:NP_201511.2scanprosite:PS00116SMART:SM00486STRING:3702.AT5G67100.1
SUPFAM:SSF53098SUPFAM:SSF56672TAIR:AT5G67100tair10-symbols:ICU2TIGRfam:TIGR00592UniGene:At.28826UniProt:Q9FHA3
Coordinates (TAIR10) chr5:+:26776994..26785104
Molecular Weight (calculated) 170488.00 Da
IEP (calculated) 7.89
GRAVY (calculated) -0.46
Length 1524 amino acids
Sequence (TAIR10)
(BLAST)
0001: MSGDNSTETG RRRSRGAEAS SRKDTLERLK AIRQGGIRSA SGGGYDIRLQ KPIFDTVDDE EYDALVSRRR EEARGFVVED GEGGDLGYLD EGEEEDWSKP
0101: SGPESTDESD DGGRFSGRLK KKKKGKEQTQ QPQVKKVNPA LKAAATITGE GRLSSMFTSS SFKKVKETDK AQYEGILDEI IAQVTPDESD RKKHTRRKLP
0201: GTVPVTIFKN KKLFSVASSM GMKESEPTPS TYEGDSVSMD NELMKEEDMK ESEVIPSETM ELLGSDIVKE DGSNKIRKTE VKSELGVKEV FTLNATIDMK
0301: EKDSALSATA GWKEAMGKVG TENGALLGSS SEGKTEFDLD ADGSLRFFIL DAYEEAFGAS MGTIYLFGKV KMGDTYKSCC VVVKNIQRCV YAIPNDSIFP
0401: SHELIMLEQE VKDSRLSPES FRGKLHEMAS KLKNEIAQEL LQLNVSNFSM APVKRNYAFE RPDVPAGEQY VLKINYSFKD RPLPEDLKGE SFSALLGSHT
0501: SALEHFILKR KIMGPCWLKI SSFSTCSPSE GVSWCKFEVT VQSPKDITIL VSEEKVVHPP AVVTAINLKT IVNEKQNISE IVSASVLCFH NAKIDVPMPA
0601: PERKRSGILS HFTVVRNPEG TGYPIGWKKE VSDRNSKNGC NVLSIENSER ALLNRLFLEL NKLDSDILVG HNISGFDLDV LLQRAQACKV QSSMWSKIGR
0701: LKRSFMPKLK GNSNYGSGAT PGLMSCIAGR LLCDTDLCSR DLLKEVSYSL TDLSKTQLNR DRKEIAPNDI PKMFQSSKTL VELIECGETD AWLSMELMFH
0801: LSVLPLTLQL TNISGNLWGK TLQGARAQRI EYYLLHTFHS KKFILPDKIS QRMKEIKSSK RRMDYAPEDR NVDELDADLT LENDPSKGSK TKKGPAYAGG
0901: LVLEPKRGLY DKYVLLLDFN SLYPSIIQEY NICFTTIPRS EDGVPRLPSS QTPGILPKLM EHLVSIRKSV KLKMKKETGL KYWELDIRQQ ALKLTANSMY
1001: GCLGFSNSRF YAKPLAELIT LQGRDILQRT VDLVQNHLNL EVIYGDTDSI MIHSGLDDIE EVKAIKSKVI QEVNKKYRCL KIDCDGIYKR MLLLRKKKYA
1101: AVKLQFKDGK PCEDIERKGV DMVRRDWSLL SKEIGDLCLS KILYGGSCED VVEAIHNELM KIKEEMRNGQ VALEKYVITK TLTKPPAAYP DSKSQPHVQV
1201: ALRMRQRGYK EGFNAKDTVP YIICYEQGNA SSASSAGIAE RARHPDEVKS EGSRWLVDID YYLAQQIHPV VSRLCAEIQG TSPERLAECL GLDPSKYRSK
1301: SNDATSSDPS TSLLFATSDE ERYKSCEPLA LTCPSCSTAF NCPSIISSVC ASISKKPATP ETEESDSTFW LKLHCPKCQQ EDSTGIISPA MIANQVKRQI
1401: DGFVSMYYKG IMVCEDESCK HTTRSPNFRL LGERERGTVC PNYPNCNGTL LRKYTEADLY KQLSYFCHIL DTQCSLEKMD VGVRIQVEKA MTKIRPAVKS
1501: AAAITRSSRD RCAYGWMQLT DIVI
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)