AT5G67100.1
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Subcellular Consensus
(Prediction and Experimental) min:  :max.
SUBAcon:nucleus 1.000 ASURE: nucleus What is SUBAcon? |
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| Experimental Localisations and PPI |
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SUBAcon links
AGI-AGI relationships |
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| Description (TAIR10) | protein_coding : DNA-directed DNA polymerases | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Curator Summary (TAIR10) |
Encodes the putative catalytic subunit of the DNA polymerase alpha. Interacts with genes involved in chromatin-mediated cellular memory. ICU2 genetically interacts with TERMINAL FLOWER2, the ortholog of HETEROCHROMATIN PROTEIN1 of animals and yeasts, and with the Polycomb group (PcG) gene CURLY LEAF. A number of regulatory genes were derepressed in the icu2-1 mutant, including genes associated with flowering time, floral meristem, and floral organ identity. Mutant has curled, involute leaves and causes early flowering. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Computational Description (TAIR10) |
INCURVATA2 (ICU2); FUNCTIONS IN: DNA-directed DNA polymerase activity; INVOLVED IN: negative regulation of flower development, leaf morphogenesis; LOCATED IN: nucleus; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA polymerase, family B (InterPro:IPR022762), DNA-directed DNA polymerase, family B, exonuclease domain (InterPro:IPR006133), DNA-directed DNA polymerase, family B, conserved region (InterPro:IPR006134), Zinc finger, DNA-directed DNA polymerase, family B, alpha (InterPro:IPR015088), Polynucleotidyl transferase, ribonuclease H fold (InterPro:IPR012337), DNA-directed DNA polymerase, family B, conserved site (InterPro:IPR017964), DNA-directed DNA polymerase, family B (InterPro:IPR006172), DNA-directed DNA polymerase, family B, pol2 (InterPro:IPR004578); BEST Arabidopsis thaliana protein match is: DNA binding;nucleotide binding;nucleic acid binding;DNA-directed DNA polymerases;DNA-directed DNA polymerases (TAIR:AT5G63960.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink). | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Annotations |
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| Coordinates (TAIR10) | chr5:+:26776994..26785104 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Molecular Weight (calculated) | 170488.00 Da | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| IEP (calculated) | 7.89 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| GRAVY (calculated) | -0.46 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Length | 1524 amino acids | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sequence (TAIR10) (BLAST) |
0001: MSGDNSTETG RRRSRGAEAS SRKDTLERLK AIRQGGIRSA SGGGYDIRLQ KPIFDTVDDE EYDALVSRRR EEARGFVVED GEGGDLGYLD EGEEEDWSKP 0101: SGPESTDESD DGGRFSGRLK KKKKGKEQTQ QPQVKKVNPA LKAAATITGE GRLSSMFTSS SFKKVKETDK AQYEGILDEI IAQVTPDESD RKKHTRRKLP 0201: GTVPVTIFKN KKLFSVASSM GMKESEPTPS TYEGDSVSMD NELMKEEDMK ESEVIPSETM ELLGSDIVKE DGSNKIRKTE VKSELGVKEV FTLNATIDMK 0301: EKDSALSATA GWKEAMGKVG TENGALLGSS SEGKTEFDLD ADGSLRFFIL DAYEEAFGAS MGTIYLFGKV KMGDTYKSCC VVVKNIQRCV YAIPNDSIFP 0401: SHELIMLEQE VKDSRLSPES FRGKLHEMAS KLKNEIAQEL LQLNVSNFSM APVKRNYAFE RPDVPAGEQY VLKINYSFKD RPLPEDLKGE SFSALLGSHT 0501: SALEHFILKR KIMGPCWLKI SSFSTCSPSE GVSWCKFEVT VQSPKDITIL VSEEKVVHPP AVVTAINLKT IVNEKQNISE IVSASVLCFH NAKIDVPMPA 0601: PERKRSGILS HFTVVRNPEG TGYPIGWKKE VSDRNSKNGC NVLSIENSER ALLNRLFLEL NKLDSDILVG HNISGFDLDV LLQRAQACKV QSSMWSKIGR 0701: LKRSFMPKLK GNSNYGSGAT PGLMSCIAGR LLCDTDLCSR DLLKEVSYSL TDLSKTQLNR DRKEIAPNDI PKMFQSSKTL VELIECGETD AWLSMELMFH 0801: LSVLPLTLQL TNISGNLWGK TLQGARAQRI EYYLLHTFHS KKFILPDKIS QRMKEIKSSK RRMDYAPEDR NVDELDADLT LENDPSKGSK TKKGPAYAGG 0901: LVLEPKRGLY DKYVLLLDFN SLYPSIIQEY NICFTTIPRS EDGVPRLPSS QTPGILPKLM EHLVSIRKSV KLKMKKETGL KYWELDIRQQ ALKLTANSMY 1001: GCLGFSNSRF YAKPLAELIT LQGRDILQRT VDLVQNHLNL EVIYGDTDSI MIHSGLDDIE EVKAIKSKVI QEVNKKYRCL KIDCDGIYKR MLLLRKKKYA 1101: AVKLQFKDGK PCEDIERKGV DMVRRDWSLL SKEIGDLCLS KILYGGSCED VVEAIHNELM KIKEEMRNGQ VALEKYVITK TLTKPPAAYP DSKSQPHVQV 1201: ALRMRQRGYK EGFNAKDTVP YIICYEQGNA SSASSAGIAE RARHPDEVKS EGSRWLVDID YYLAQQIHPV VSRLCAEIQG TSPERLAECL GLDPSKYRSK 1301: SNDATSSDPS TSLLFATSDE ERYKSCEPLA LTCPSCSTAF NCPSIISSVC ASISKKPATP ETEESDSTFW LKLHCPKCQQ EDSTGIISPA MIANQVKRQI 1401: DGFVSMYYKG IMVCEDESCK HTTRSPNFRL LGERERGTVC PNYPNCNGTL LRKYTEADLY KQLSYFCHIL DTQCSLEKMD VGVRIQVEKA MTKIRPAVKS 1501: AAAITRSSRD RCAYGWMQLT DIVI |
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| See Also |
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Citation
If you find this resource useful please cite one of the following publications:
Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)
Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)