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AT5G62530.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
mitochondrion 1.000
ASURE: mitochondrion
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : aldehyde dehydrogenase 12A1
Curator
Summary (TAIR10)
Encodes mitochondrial Delta-pyrroline-5- carboxylate dehydrogenase. Involved in the catabolism of proline to glutamate. Involved in protection from proline toxicity. Induced at pathogen infection sites. P5CDH and SRO5 (an overlapping gene in the sense orientation) generate 24-nt and 21-nt siRNAs, which together are components of a regulatory loop controlling reactive oxygen species (ROS) production and stress response.
Computational
Description (TAIR10)
aldehyde dehydrogenase 12A1 (ALDH12A1); FUNCTIONS IN: 3-chloroallyl aldehyde dehydrogenase activity, cobalt ion binding, zinc ion binding, 1-pyrroline-5-carboxylate dehydrogenase activity; INVOLVED IN: oxygen and reactive oxygen species metabolic process, response to salt stress, proline catabolic process to glutamate, proline metabolic process; LOCATED IN: mitochondrion, chloroplast; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aldehyde/histidinol dehydrogenase (InterPro:IPR016161), Aldehyde dehydrogenase (InterPro:IPR015590), Aldehyde dehydrogenase, N-terminal (InterPro:IPR016162), Aldehyde dehydrogenase, conserved site (InterPro:IPR016160); BEST Arabidopsis thaliana protein match is: aldehyde dehydrogenase 7B4 (TAIR:AT1G54100.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT5G62530-MONOMERBRENDA:1.2.1.88EC:1.2.1.88eggNOG:COG4230eggNOG:ENOG410INEBEMBL:AB015469EMBL:AY039787
EMBL:AY065072EMBL:BT000746EMBL:BT010391EMBL:CP002688EnsemblPlants:AT5G62530EnsemblPlants:AT5G62530.1entrez:836373
Gene3D:3.40.309.10Gene3D:3.40.605.10GeneID:836373Genevisible:Q8VZC3GO:GO:0003842GO:GO:0004028GO:GO:0004029
GO:GO:0005739GO:GO:0005759GO:GO:0006560GO:GO:0008270GO:GO:0009507GO:GO:0009651GO:GO:0010133
GO:GO:0050897GO:GO:0072593Gramene:AT5G62530.1gramene_pathway:1.5.1.12gramene_pathway:PWY-4561hmmpanther:PTHR11699hmmpanther:PTHR11699:SF148
HOGENOM:HOG000264826InParanoid:Q8VZC3IntAct:Q8VZC3InterPro:IPR015590InterPro:IPR016160InterPro:IPR016161InterPro:IPR016162
InterPro:IPR016163KEGG:ath:AT5G62530KO:K00294OMA:MYGDISAPaxDb:Q8VZC3Pfam:PF00171Pfam:Q8VZC3
PhylomeDB:Q8VZC3PRIDE:Q8VZC3PRO:PR:Q8VZC3PROSITE:PS00070ProteinModelPortal:Q8VZC3Proteomes:UP000006548RefSeq:NP_568955.1
scanprosite:PS00070SMR:Q8VZC3STRING:3702.AT5G62530.1SUPFAM:SSF53720TAIR:AT5G62530tair10-symbols:ALDH12A1tair10-symbols:ATP5CDH
tair10-symbols:P5CDHUniGene:At.75205UniGene:At.9309UniPathway:UPA00261UniProt:Q8VZC3
Coordinates (TAIR10) chr5:-:25099768..25103159
Molecular Weight (calculated) 61776.40 Da
IEP (calculated) 6.72
GRAVY (calculated) -0.17
Length 556 amino acids
Sequence (TAIR10)
(BLAST)
001: MYRVFASRAL RAKSLCDKSS TSLASLTLSR LNHSIPFATV DAEELSGAHP AEVQSFVQGK WIGSSNHNTL LDPLNGEPFI KVAEVDESGT QPFVDSLSQC
101: PKHGLHNPFK SPERYLLYGD ISTKAAHMLA LPKVADFFAR LIQRVAPKSY QQAAGEVFVT RKFLENFCGD QVRFLARSFA IPGNHLGQQS HGYRWPYGPV
201: TIVTPFNFPL EIPLLQLMGA LYMGNKPLLK VDSKVSIVME QMMRLLHYCG LPAEDVDFIN SDGKTMNKIL LEANPRMTLF TGSSRVAEKL ALDLKGRIRL
301: EDAGFDWKVL GPDVQEVDYV AWQCDQDAYA CSGQKCSAQS MLFVHENWSK TPLVSKLKEL AERRKLEDLT IGPVLTFTTE AMLEHMENLL QIPGSKLLFG
401: GKELKNHSIP SIYGALEPTA VYVPIEEILK DNKTYELVTK EIFGPFQIVT EYKKDQLPLV LEALERMHAH LTAAVVSNDP IFLQEVIGNS VNGTTYAGLR
501: GRTTGAPQNH WFGPAGDPRG AGIGTPEAIK LVWSCHREVI YDYGPVPQGW ELPPST
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)