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AT5G60600.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
plastid 1.000
ASURE: plastid
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : 4-hydroxy-3-methylbut-2-enyl diphosphate synthase
Curator
Summary (TAIR10)
Encodes a chloroplast-localized hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) synthase (HDS), catalyzes the formation of HMBPP from 2-C-methyl-D-erythrytol 2,4-cyclodiphosphate (MEcPP). The HDS enzyme controls the penultimate steps of the biosynthesis of IPP and dimethylallyl diphosphate (DMAPP) via the MEP pathway and may serve as a metabolic control point for SA-mediated disease resistance. In the light, the electrons required for the reaction catalyzed by HDS are directly provided by the electron flow from photosynthesis via ferredoxin. In the dark however, the enzyme requires an electron shuttle: ferredoxin-NADP<sup>+</sup> reductase.
Computational
Description (TAIR10)
4-hydroxy-3-methylbut-2-enyl diphosphate synthase (HDS); FUNCTIONS IN: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity, 4 iron, 4 sulfur cluster binding; INVOLVED IN: response to light stimulus, isoprenoid biosynthetic process, isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway, response to bacterium, systemic acquired resistance, salicylic acid mediated signaling pathway; LOCATED IN: chloroplast stroma, chloroplast, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Dihydropteroate synthase-like (InterPro:IPR011005), 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, atypical (InterPro:IPR017178), 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type (InterPro:IPR004588); Has 12699 Blast hits to 7350 proteins in 2074 species: Archae - 0; Bacteria - 8133; Metazoa - 2; Fungi - 2; Plants - 72; Viruses - 0; Other Eukaryotes - 4490 (source: NCBI BLink).
Protein Annotations
BioCyc:MetaCyc:AT5G60600-MONOMERBioGrid:21425EC:1.17.7.1eggNOG:COG0821eggNOG:ENOG410IHS3EMBL:AB005246EMBL:AF434673
EMBL:AY081261EMBL:AY094472EMBL:BT010473EMBL:CP002688EnsemblPlants:AT5G60600EnsemblPlants:AT5G60600.1entrez:836181
ExpressionAtlas:F4K0E8GeneID:836181Genevisible:F4K0E8GO:GO:0005506GO:GO:0009507GO:GO:0009570GO:GO:0009617
GO:GO:0009862GO:GO:0009941GO:GO:0016114GO:GO:0019288GO:GO:0046429GO:GO:0051539gramene_pathway:1.17.7.1
gramene_pathway:NONMEVIPP-PWYgramene_plant_reactome:1119464gramene_plant_reactome:6877105HAMAP:MF_00159hmmpanther:PTHR30454HOGENOM:HOG000261018InParanoid:F4K0E8
InterPro:IPR004588InterPro:IPR017178KEGG:00900+1.17.7.3OMA:ICKEYGTPaxDb:F4K0E8Pfam:F4K0E8Pfam:PF04551
PIRSF:PIRSF037336PRIDE:F4K0E8PRO:PR:F4K0E8ProteinModelPortal:F4K0E8Proteomes:UP000006548RefSeq:NP_200868.2RefSeq:NP_851233.1
SMR:F4K0E8STRING:3702.AT5G60600.1SUPFAM:SSF56014TAIR:AT5G60600tair10-symbols:CLB4tair10-symbols:CSB3tair10-symbols:GCPE
tair10-symbols:HDStair10-symbols:ISPGTIGRfam:TIGR00612TIGRFAMs:TIGR00612UniGene:At.21376UniGene:At.72025UniPathway:UPA00056
UniProt:F4K0E8
Coordinates (TAIR10) chr5:+:24359447..24363274
Molecular Weight (calculated) 82261.30 Da
IEP (calculated) 6.39
GRAVY (calculated) -0.20
Length 741 amino acids
Sequence (TAIR10)
(BLAST)
001: MATGVLPAPV SGIKIPDSKV GFGKSMNLVR ICDVRSLRSA RRRVSVIRNS NQGSDLAELQ PASEGSPLLV PRQKYCESLH KTVRRKTRTV MVGNVALGSE
101: HPIRIQTMTT SDTKDITGTV DEVMRIADKG ADIVRITVQG KKEADACFEI KDKLVQLNYN IPLVADIHFA PTVALRVAEC FDKIRVNPGN FADRRAQFET
201: IDYTEDEYQK ELQHIEQVFT PLVEKCKKYG RAMRIGTNHG SLSDRIMSYY GDSPRGMVES AFEFARICRK LDYHNFVFSM KASNPVIMVQ AYRLLVAEMY
301: VHGWDYPLHL GVTEAGEGED GRMKSAIGIG TLLQDGLGDT IRVSLTEPPE EEIDPCRRLA NLGTKAAKLQ QGVAPFEEKH RHYFDFQRRT GDLPVQKEGE
401: EVDYRNVLHR DGSVLMSISL DQLKAPELLY RSLATKLVVG MPFKDLATVD SILLRELPPV DDQVARLALK RLIDVSMGVI APLSEQLTKP LPNAMVLVNL
501: KELSGGAYKL LPEGTRLVVS LRGDEPYEEL EILKNIDATM ILHDVPFTED KVSRVHAARR LFEFLSENSV NFPVIHHINF PTGIHRDELV IHAGTYAGGL
601: LVDGLGDGVM LEAPDQDFDF LRNTSFNLLQ GCRMRNTKTE YVSCPSCGRT LFDLQEISAE IREKTSHLPG VSIAIMGCIV NGPGEMADAD FGYVGGSPGK
701: IDLYVGKTVV KRGIAMTEAT DALIGLIKEH GRWVDPPVAD E
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)