suba logo
AT5G58220.1
Subcellular Consensus
(Prediction and Experimental)

min: heatmap :max

.
SUBAcon:
peroxisome 1.000
ASURE: peroxisome
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : transthyretin-like protein
Curator
Summary (TAIR10)
Encodes a transthyretin-like S-allantoin synthase protein that catalyzes two steps in the allantoin biosynthesis pathway by acting as a hydroxyisourate hydrolase and a 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) decarboxylase. Two alternatively spliced versions of the transcript give rise to a longer peroxisomally-targeted protein (AT5G58220.1 (called TTL1-)) and a slightly shorter cytoplasmic protein (AT5G58220.3 (called TTL2-)). Both have roughly equivalent enzymatic activity in vitro, but, allantoin biosynthesis is believed to occur in the peroxisome suggesting that the cytosolic form may participate in a different process.
Computational
Description (TAIR10)
transthyretin-like protein (TTL); FUNCTIONS IN: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity, hydroxyisourate hydrolase activity; INVOLVED IN: regulation of cell growth by extracellular stimulus, brassinosteroid mediated signaling pathway, protein homotetramerization, allantoin biosynthetic process; LOCATED IN: extrinsic to internal side of plasma membrane, peroxisome; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Bifunctional hydroxyisourate hydrolase/2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (InterPro:IPR017129), Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (InterPro:IPR018020), Hydroxyisourate hydrolase (InterPro:IPR014306), Transthyretin/hydroxyisourate hydrolase (InterPro:IPR000895); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT5G58220-MONOMERBioCyc:ARA:GQT-2131-MONOMERBioCyc:ARA:GQT-2730-MONOMERBioCyc:MetaCyc:AT5G58220-MONOMERBioGrid:21178BRENDA:4.1.1.97DNASU:835934
EC:3.5.2.17EC:4.1.1.97eggNOG:COG2351eggNOG:KOG3006EMBL:AB019228EMBL:AK226943EMBL:AY062771
EMBL:AY081647EMBL:CP002688EnsemblPlants:AT5G58220EnsemblPlants:AT5G58220.1entrez:835934EvolutionaryTrace:Q9LVM5ExpressionAtlas:Q9LVM5
Gene3D:1.10.3330.10Gene3D:2.60.40.180GeneID:835934Genevisible:Q9LVM5GO:GO:0001560GO:GO:0005777GO:GO:0005829
GO:GO:0006144GO:GO:0009742GO:GO:0019428GO:GO:0019628GO:GO:0031234GO:GO:0033971GO:GO:0051289
GO:GO:0051997hmmpanther:PTHR10395hmmpanther:PTHR10395:SF7HOGENOM:HOG000012804InParanoid:Q9LVM5IntAct:Q9LVM5InterPro:IPR000895
InterPro:IPR014306InterPro:IPR017129InterPro:IPR018020InterPro:IPR023416InterPro:IPR023418InterPro:IPR023419iPTMnet:Q9LVM5
KEGG:00230+3.5.2.17KEGG:00230+3.5.2.17+4.1.1.97KEGG:00230+4.1.1.97KEGG:ath:AT5G58220KO:K13484OMA:LACCGSTPaxDb:Q9LVM5
PDB:2Q37PDBsum:2Q37Pfam:PF00576Pfam:PF09349Pfam:Q9LVM5PhylomeDB:Q9LVM5PIRSF:PIRSF037178
PRIDE:Q9LVM5PRINTS:PR00189PRO:PR:Q9LVM5PROSITE:PS00768PROSITE:PS00769ProteinModelPortal:Q9LVM5Proteomes:UP000006548
RefSeq:NP_001032093.1RefSeq:NP_001032094.1RefSeq:NP_200630.1scanprosite:PS00768scanprosite:PS00769SMR:Q9LVM5STRING:3702.AT5G58220.1
SUPFAM:SSF158694SUPFAM:SSF49472TAIR:AT5G58220tair10-symbols:TTLTCDB:9.B.35.1.3TIGRfam:TIGR02962TIGRFAMs:TIGR02962
UniGene:At.27237UniPathway:UPA00394UniProt:Q9LVM5
Coordinates (TAIR10) chr5:-:23554546..23555861
Molecular Weight (calculated) 35566.00 Da
IEP (calculated) 6.60
GRAVY (calculated) -0.22
Length 324 amino acids
Sequence (TAIR10)
(BLAST)
001: MAMEIGEDEW KVCCGSSEFA KQMSTSGPLT SQEAIYTARD IWFNQVNVTD WLEAFSAHPQ IGNTPSPSIN SDFARRSVSE QSTAFATTSA SALQELAEWN
101: VLYKKKFGFI FIICASGRTH AEMLHALKER YENRPIVELE IAAMEQMKIT ELRMAKLFSD KAKVISETDS SSSPVSTKPQ DRLRIIGGHL NVAAEAKAPK
201: RSRPPITTHV LDVSRGAPAA GVEVHLEVWS GTTGPSFVHG GGGVWSSVGT SATDRDGRSG PLMDLVDALN PGTYRISFDT AKYSPGCFFP YVSIVFQVTE
301: SQKWEHFHVP LLLAPFSFST YRGS
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)