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AT5G57090.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
plasma membrane 1.000
ASURE: plasma membrane
What is SUBAcon?
What is ASURE?
SUBAcon computations
Predictors External Curations
AmiGO : plasma membrane 19004783
AmiGO : plasma membrane 9843496
AmiGO : vacuole 19004783
SwissProt : plasma membrane 16381842
TAIR : plasma membrane 9843496
TAIR : vacuole 19004783
TAIR : plasma membrane 19004783
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:9843496 (1998): plasma membrane
  • PMID:17306539 (2007): endoplasmic reticulum
  • PMID:17306539 (2007): plasma membrane
  • PMID:15659621 (2005): plasma membrane
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : Auxin efflux carrier family protein
Curator
Summary (TAIR10)
Encodes an auxin efflux carrier that is similar to bacterial membrane transporters. Root-specific role in the transport of auxin. Acts downstream of CTR1 and ethylene biosynthesis, in the same pathway as EIN2 and AUX1, and independent from EIN3 and EIN5/AIN1 pathway. In the root, the protein localizes apically in epidermal and lateral root cap cells and predominantly basally in cortical cells. Functions may be regulated by phosphorylation status. EIR1 expression is induced by brassinolide treatment in the brassinosteroid-insensitive br1 mutant. Gravistimulation resulted in asymmetric PIN2 distribution, with more protein degraded at the upper side of the gravistimulated root. Protein turnover is affected by the proteasome and by endosomal cycling. Plasma membrane-localized PIN proteins mediate a saturable efflux of auxin. PINs mediate auxin efflux from mammalian and yeast cells without needing additional plant-specific factors. The action of PINs in auxin efflux is distinct from PGPs, rate-limiting, specific to auxins and sensitive to auxin transport inhibitors. Membrane sterol composition is essential for the acquisition of PIN2 polarity.
Computational
Description (TAIR10)
ETHYLENE INSENSITIVE ROOT 1 (EIR1); CONTAINS InterPro DOMAIN/s: Auxin efflux carrier, subgroup (InterPro:IPR014024), Auxin efflux carrier (InterPro:IPR004776); BEST Arabidopsis thaliana protein match is: Auxin efflux carrier family protein (TAIR:AT2G01420.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
Protein Annotations
eggNOG:ENOG410IKMZeggNOG:ENOG410YAJ0EMBL:AK176358EnsemblPlants:AT5G57090EnsemblPlants:AT5G57090.1entrez:835813ExpressionAtlas:Q67YW0
GeneID:835813GO:GO:0005886GO:GO:0009734GO:GO:0010315GO:GO:0016021GO:GO:0055085Gramene:AT5G57090.1
hmmpanther:PTHR31752hmmpanther:PTHR31752:SF4InterPro:IPR004776InterPro:IPR014024KEGG:ath:AT5G57090KO:K13947OMA:IQMPSIV
PaxDb:Q67YW0Pfam:PF03547Pfam:Q9LU77PhylomeDB:Q67YW0PRIDE:Q67YW0ProteinModelPortal:Q67YW0RefSeq:NP_568848.1
STRING:3702.AT5G57090.1TAIR:AT5G57090tair10-symbols:AGRtair10-symbols:AGR1tair10-symbols:ATPIN2tair10-symbols:EIR1tair10-symbols:PIN2
tair10-symbols:WAV6TIGRfam:TIGR00946TIGRFAMs:TIGR00946TMHMM:TMhelixUniGene:At.9674UniProt:Q67YW0UniProt:Q9LU77
Coordinates (TAIR10) chr5:+:23100765..23104456
Molecular Weight (calculated) 69335.10 Da
IEP (calculated) 9.75
GRAVY (calculated) 0.10
Length 647 amino acids
Sequence (TAIR10)
(BLAST)
001: MITGKDMYDV LAAMVPLYVA MILAYGSVRW WGIFTPDQCS GINRFVAVFA VPLLSFHFIS SNDPYAMNYH FLAADSLQKV VILAALFLWQ AFSRRGSLEW
101: MITLFSLSTL PNTLVMGIPL LRAMYGDFSG NLMVQIVVLQ SIIWYTLMLF LFEFRGAKLL ISEQFPETAG SITSFRVDSD VISLNGREPL QTDAEIGDDG
201: KLHVVVRRSS AASSMISSFN KSHGGGLNSS MITPRASNLT GVEIYSVQSS REPTPRASSF NQTDFYAMFN ASKAPSPRHG YTNSYGGAGA GPGGDVYSLQ
301: SSKGVTPRTS NFDEEVMKTA KKAGRGGRSM SGELYNNNSV PSYPPPNPMF TGSTSGASGV KKKESGGGGS GGGVGVGGQN KEMNMFVWSS SASPVSEANA
401: KNAMTRGSST DVSTDPKVSI PPHDNLATKA MQNLIENMSP GRKGHVEMDQ DGNNGGKSPY MGKKGSDVED GGPGPRKQQM PPASVMTRLI LIMVWRKLIR
501: NPNTYSSLFG LAWSLVSFKW NIKMPTIMSG SISILSDAGL GMAMFSLGLF MALQPKIIAC GKSVAGFAMA VRFLTGPAVI AATSIAIGIR GDLLHIAIVQ
601: AALPQGIVPF VFAKEYNVHP DILSTAVIFG MLVALPVTVL YYVLLGL
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)