suba logo
AT5G56290.1
Subcellular Consensus
(Prediction and Experimental)

min: heatmap :max

.
SUBAcon:
peroxisome 0.500
cytosol 0.500
ASURE: cytosol,peroxisome
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:24134884 (2013): cytoskeleton microtubules
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : peroxin 5
Curator
Summary (TAIR10)
Encodes the peroxisomal targeting signal type 1 receptor that facilitates peroxisomal protein translocation. It recognizes proteins with the PTS1 consensus sequence (tripeptide SKL or a conserved variant) at the extreme C terminus. The protein has several domains, including C-terminal tetratricopeptide repeat motifs which act in binding the C-terminal "SKL" targeting signal. The mechanism of transport has been worked out in other organisms: The receptor recognizes and binds cytosolic PTS1-containing proteins. The PEX5-PTS1 complex binds a PEX14/PEX13 receptor complex at the peroxisome membrane and is translocated into the peroxisome matrix in a process dependent on PEX2,PEX10, and PEX12. In the peroxisome matrix, PEX5 releases its cargo and is recycled to the cytosol in a process dependent on PEX1, PEX4, PEX6 and PEX22. It is also involved, in conjunction with PEX7, in PTS1- and PTS2-dependent peroxisomal protein import. RNAi experiments suggest that PEX5 is necessary for the maintenance of both glyoxysomal and leaf peroxisomal functions.
Computational
Description (TAIR10)
peroxin 5 (PEX5); CONTAINS InterPro DOMAIN/s: Tetratricopeptide TPR-1 (InterPro:IPR001440), Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734); BEST Arabidopsis thaliana protein match is: Tetratricopeptide repeat (TPR)-like superfamily protein (TAIR:AT3G11540.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
Protein Annotations
BioGrid:20972eggNOG:ENOG410XQ6QeggNOG:KOG1125EMBL:AB009049EMBL:AB026656EMBL:AF074843EMBL:AY056299
EMBL:AY096679EMBL:CP002688EnsemblPlants:AT5G56290EnsemblPlants:AT5G56290.1entrez:835728Gene3D:1.25.40.10GeneID:835728
Genevisible:Q9FMA3GO:GO:0005052GO:GO:0005778GO:GO:0005829GO:GO:0006625GO:GO:0009733GO:GO:0016560
Gramene:AT5G56290.1hmmpanther:PTHR10130hmmpanther:PTHR10130:SF0HOGENOM:HOG000264895InParanoid:Q9FMA3IntAct:Q9FMA3InterPro:IPR001440
InterPro:IPR011990InterPro:IPR013026InterPro:IPR019734InterPro:IPR024111iPTMnet:Q9FMA3KEGG:ath:AT5G56290KO:K13342
ncoils:CoilOMA:QPTDSPYPANTHER:PTHR10130PaxDb:Q9FMA3Pfam:PF00515Pfam:PF07719Pfam:PF13181
Pfam:PF13414Pfam:Q9FMA3Pfscan:PS50005Pfscan:PS50293PhylomeDB:Q9FMA3PIR:T51817PRIDE:Q9FMA3
PRO:PR:Q9FMA3PROSITE:PS50005PROSITE:PS50293ProteinModelPortal:Q9FMA3Proteomes:UP000006548RefSeq:NP_200440.1SMART:SM00028
SMR:Q9FMA3STRING:3702.AT5G56290.1SUPFAM:SSF48452TAIR:AT5G56290tair10-symbols:ATPEX5tair10-symbols:PEX5TCDB:3.A.20.1.2
UniGene:At.10824UniProt:Q9FMA3
Coordinates (TAIR10) chr5:+:22786655..22791972
Molecular Weight (calculated) 80916.00 Da
IEP (calculated) 4.46
GRAVY (calculated) -0.58
Length 728 amino acids
Sequence (TAIR10)
(BLAST)
001: MAMRDLVNGG AACAVPGSSS SSNPLGALTN ALLGSSSKTQ ERLKEIPNAN RSGPRPQFYS EDQQIRSLPG SELDQPLLQP GAQGSEFFRG FRSVDQNGLG
101: AAWDEVQQGG PMPPMGPMFE PVQPTFEGPP QRVLSNFLHS FVESSRGGIP FRPAPVPVLG LSQSDKQCIR DRSSIMARHF FADRGEEFIN SQVNALLSSL
201: DIDDGIQARG HVPGRFRELD DYWNESQAVV KPNLHPADNW AAEFNQHGMD HGGPDSWVQS FEQQHGVNGW ATEFEQGQSQ LMSSQMRSMD MQNIAAMEQT
301: RKLAHTLSQD GNPKFQNSRF LQFVSKMSRG ELIIDENQVK QASAPGEWAT EYEQQYLGPP SWADQFANEK LSHGPEQWAD EFASGRGQQE TAEDQWVNEF
401: SKLNVDDWID EFAEGPVGDS SADAWANAYD EFLNEKNAGK QTSGVYVFSD MNPYVGHPEP MKEGQELFRK GLLSEAALAL EAEVMKNPEN AEGWRLLGVT
501: HAENDDDQQA IAAMMRAQEA DPTNLEVLLA LGVSHTNELE QATALKYLYG WLRNHPKYGA IAPPELADSL YHADIARLFN EASQLNPEDA DVHIVLGVLY
601: NLSREFDRAI TSFQTALQLK PNDYSLWNKL GATQANSVQS ADAISAYQQA LDLKPNYVRA WANMGISYAN QGMYKESIPY YVRALAMNPK ADNAWQYLRL
701: SLSCASRQDM IEACESRNLD LLQKEFPL
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)