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AT5G55310.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
nucleus 1.000
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : DNA topoisomerase 1 beta
Curator
Summary (TAIR10)
Encodes one of two Arabidopsis type-I DNA topoisomerase I genes. Reducing the level of expression of this gene in a top1alpha (At5g55300) mutant background causes seedling lethality.
Computational
Description (TAIR10)
DNA topoisomerase 1 beta (TOP1BETA); FUNCTIONS IN: DNA topoisomerase type I activity; INVOLVED IN: DNA topological change; LOCATED IN: membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DNA topoisomerase I, DNA binding, mixed alpha/beta motif, eukaryotic-type (InterPro:IPR013030), DNA topoisomerase I, DNA binding, eukaryotic-type (InterPro:IPR008336), DNA topoisomerase I, C-terminal (InterPro:IPR001631), DNA topoisomerase I, active site (InterPro:IPR018521), DNA topoisomerase I, catalytic core, alpha/beta subdomain, eukaryotic-type (InterPro:IPR014727), DNA topoisomerase I, catalytic core, eukaryotic-type (InterPro:IPR013500), DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type (InterPro:IPR014711), DNA topoisomerase I, C-terminal, eukaryotic-type (InterPro:IPR013499), DNA breaking-rejoining enzyme, catalytic core (InterPro:IPR011010); BEST Arabidopsis thaliana protein match is: DNA topoisomerase I alpha (TAIR:AT5G55300.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT5G55310-MONOMEReggNOG:COG3569eggNOG:KOG0981EMBL:AB015479EMBL:AK226832EMBL:CP002688EnsemblPlants:AT5G55310
EnsemblPlants:AT5G55310.1entrez:835624Gene3D:1.10.10.41Gene3D:1.10.132.10Gene3D:2.170.11.10Gene3D:3.90.15.10GeneID:835624
GO:GO:0003677GO:GO:0003917GO:GO:0003918GO:GO:0005730GO:GO:0006260GO:GO:0006265GO:GO:0006338
GO:GO:0007059GO:GO:0016020GO:GO:0031298Gramene:AT5G55310.1hmmpanther:PTHR10290hmmpanther:PTHR10290:SF3HOGENOM:HOG000105469
InterPro:IPR001631InterPro:IPR008336InterPro:IPR011010InterPro:IPR013030InterPro:IPR013034InterPro:IPR013499InterPro:IPR013500
InterPro:IPR014711InterPro:IPR014727InterPro:IPR018521InterPro:IPR025834KEGG:ath:AT5G55310KO:K03163ncoils:Coil
OMA:KPKFRENPfam:PF01028Pfam:PF02919Pfam:PF14370PhylomeDB:Q9FJ79PRINTS:PR00416PROSITE:PS00176
Proteomes:UP000006548Reactome:R-ATH-4615885RefSeq:NP_200342.1scanprosite:PS00176SMART:SM00435SMR:Q9FJ79STRING:3702.AT5G55310.1
SUPFAM:SSF56349SUPFAM:SSF56741TAIR:AT5G55310tair10-symbols:TOP1tair10-symbols:TOP1BETAUniGene:At.6889UniProt:Q9FJ79
Coordinates (TAIR10) chr5:-:22430389..22434590
Molecular Weight (calculated) 103060.00 Da
IEP (calculated) 10.11
GRAVY (calculated) -0.86
Length 917 amino acids
Sequence (TAIR10)
(BLAST)
001: MATEAFVKPV VPNGHDGYED EDEDDIPLVF KRNSNTAATT NRPSPINNAM RNSAIGSTKS SPPMRSPLTS PNRSASSSTR SSMMKPALPS SSSVQRSTLK
101: SPLRDDRSVV AKERNGFGKA PSVSKSDDED SEDDKPLSAR LKLDSKEVTK QPSSSGRGST QQAVQKSNMR PQGLSDYTKK KVLDERAPMS STVQTKTSVG
201: TSSSKPVHIE QKRPLVNNID RNGLKPKTEG HSSQAPAKRP LEKGSSSNQS SVKRPKLSEP ARPVKVEQGS HISATQDAKG KNLDASKPLR ANQATVKEDN
301: SDGDDHVPIA SRMKSDSSNN KSSSAKPSSS KMIASSSRTI AQKPNKWVKD SKYSKSSKSL PSGDGQKKWK TLQHNGVIFP PPYKRHGVKI LFQGKPVDLT
401: PEQEEVATMF AVMRETEYYK KPKFRENFWN DWRKLLGKNH MIKSLDDCDF TPIYEWYMQE KETKKQMTAE EKRIVKEEKL KQEEKYMWAV LDGVRERIGN
501: FRVEPPGLFR GRGEHPKMGK LKKRIRPCDI TINIGKEAPI PECPIPGERW KEVKHDNTVT WLAFWSDPIN PKEFKYVFLA ASSSLKGQSD KEKYEKARKL
601: HNHIGSIRAA YTKDFNNKDV TKRQIAVATY LIDKLALRAG NEKDDDEADT VGCCTLKVGN VECIPPNKLK FDFLGKDSIQ YVNTVEVEPL VYKAIGQFQA
701: GKSKTDDLFD ELDTSKLNTH LKELMAGLTA KVFRTYNASI TLDLMLSKET RDGDVPEKVV VYQQANKEVA IICNHQRTVS KSHGAQVEKL AVKIEELREQ
801: IKELNIDLDR AKKGRTPLMG SDGKRKRNLT PEALEKKIMQ TQGKIEKMER DMQTKEDMKT VALGTSKINY MDPRITVAWC KRHDVPIEKI FNKSLLAKFA
901: WAMDVDPEFR FCSSTDE
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)