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AT5G54770.1
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
plastid 1.000
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : thiazole biosynthetic enzyme, chloroplast (ARA6) (THI1) (THI4)
Curator
Summary (TAIR10)
Encodes a thiamine biosynthetic gene that has a dual function in thiamine biosynthesis and mitochondrial DNA damage tolerance. It appears to be involved in producing the thiazole portion of thiamine (vitamin B1). A crystal structure of the protein reveals that it forms a 2-ring homo-octamer.
Computational
Description (TAIR10)
THI1; FUNCTIONS IN: protein homodimerization activity, zinc ion binding; INVOLVED IN: oxazole or thiazole biosynthetic process, response to cold, thiamin biosynthetic process, response to DNA damage stimulus; LOCATED IN: in 6 components; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Thiamine biosynthesis Thi4 protein (InterPro:IPR002922); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
Protein Annotations
BioCyc:MetaCyc:AT5G54770-MONOMERBioGrid:20811eggNOG:COG1635eggNOG:KOG2960
EMBL:AB005232EMBL:AF419604EMBL:AF428355EMBL:AF428385
EMBL:AY054216EMBL:AY058094EMBL:AY143082EMBL:CP002688
EMBL:U17589EnsemblPlants:AT5G54770EnsemblPlants:AT5G54770.1entrez:835567
EvolutionaryTrace:Q38814Gene3D:3.50.50.60GeneID:835567Genevisible:Q38814
GO:GO:0005739GO:GO:0006974GO:GO:0008270GO:GO:0009228
GO:GO:0009409GO:GO:0009507GO:GO:0009570GO:GO:0009579
GO:GO:0009941GO:GO:0010319GO:GO:0016491GO:GO:0018131
GO:GO:0042803HAMAP:MF_03158hmmpanther:PTHR10617hmmpanther:PTHR10617:SF115
HOGENOM:HOG000106048InParanoid:Q38814IntAct:Q38814InterPro:IPR002922
InterPro:IPR023753InterPro:IPR027495KEGG:ath:AT5G54770KO:K03146
MINT:MINT-8071157OMA:RMGPVFGPaxDb:Q38814PDB:1RP0
PDBsum:1RP0Pfam:PF01946Pfam:Q38814PhylomeDB:Q38814
PIR:S71191PRIDE:Q38814PRO:PR:Q38814ProteinModelPortal:Q38814
Proteomes:UP000006548RefSeq:NP_200288.1SMR:Q38814STRING:3702.AT5G54770.1
SUPFAM:SSF51905TAIR:AT5G54770tair10-symbols:THI1tair10-symbols:THI4
tair10-symbols:TZTIGRfam:TIGR00292TIGRFAMs:TIGR00292UniGene:At.24888
UniProt:Q38814
Coordinates (TAIR10) chr5:+:22246634..22247891
Molecular Weight (calculated) 36666.40 Da
IEP (calculated) 6.17
GRAVY (calculated) 0.22
Length 349 amino acids
Sequence (TAIR10)
(BLAST)
001: MAAIASTLSL SSTKPQRLFD SSFHGSAISA APISIGLKPR SFSVRATTAG YDLNAFTFDP IKESIVSREM TRRYMTDMIT YAETDVVVVG AGSAGLSAAY
101: EISKNPNVQV AIIEQSVSPG GGAWLGGQLF SAMIVRKPAH LFLDEIGVAY DEQDTYVVVK HAALFTSTIM SKLLARPNVK LFNAVAAEDL IVKGNRVGGV
201: VTNWALVAQN HHTQSCMDPN VMEAKIVVSS CGHDGPFGAT GVKRLKSIGM IDHVPGMKAL DMNTAEDAIV RLTREVVPGM IVTGMEVAEI DGAPRMGPTF
301: GAMMISGQKA GQLALKALGL PNAIDGTLVG NLSPELVLAA ADSAETVDA
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)