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AT5G50600.1
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
extracellular 0.608
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no coexpression data
Description (TAIR10) protein_coding : hydroxysteroid dehydrogenase 1
Curator
Summary (TAIR10)
Encodes a hydroxysteroid dehydrogenase HSD1. Two copies of HSD1 (At5g50600 and At5g50700) exist in the Arabidopsis genome as a result of an exact 33-kb duplication on chromosome 5 encompassing seven genes. There are five homologs of HSD1 in Arabidopsis (HSD2-At3g47350, HSD3-At3g47360, HSD4-At5g50590, HSD4-At5g50690 and HSD6-At5g50770; HSD4 has two copies due to the same gene duplication event occurred to HSD1) (Plant Cell Physiology 50:1463). At5g50690 is also named as HSD7 (Plant Physiology 145:87). HSD1 is identified from the proteome of oil bodies from mature seeds. Transcription of HSD1 is specifically and highly induced in oil-accumulating tissues of mature seeds; transcript disappears during germination.
Computational
Description (TAIR10)
hydroxysteroid dehydrogenase 1 (HSD1); FUNCTIONS IN: oxidoreductase activity, binding, catalytic activity; INVOLVED IN: response to abscisic acid stimulus, response to brassinosteroid stimulus; LOCATED IN: endomembrane system; EXPRESSED IN: 9 plant structures; CONTAINS InterPro DOMAIN/s: Short-chain dehydrogenase/reductase, conserved site (InterPro:IPR020904), NAD(P)-binding domain (InterPro:IPR016040), Glucose/ribitol dehydrogenase (InterPro:IPR002347), Short-chain dehydrogenase/reductase SDR (InterPro:IPR002198); BEST Arabidopsis thaliana protein match is: hydroxysteroid dehydrogenase 1 (TAIR:AT5G50700.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
Protein Annotations
BioGrid:20375BioGrid:20387EC:1.1.1.-EC:1.1.1.146
eggNOG:COG1028eggNOG:KOG1205EMBL:AB025619EMBL:AF446888
EMBL:AK221698EMBL:AY052660EMBL:AY062768EMBL:AY081653
EMBL:CP002688EnsemblPlants:AT5G50600EnsemblPlants:AT5G50600.1EnsemblPlants:AT5G50700.1
entrez:835129entrez:835141Gene3D:3.40.50.720GeneID:835129
GeneID:835141Genevisible:P0DKC5GO:GO:0005811GO:GO:0006694
GO:GO:0016021GO:GO:0070524Gramene:AT5G50600.1Gramene:AT5G50700.1
hmmpanther:PTHR24322hmmpanther:PTHR24322:SF501InParanoid:P0DKC5InterPro:IPR002347
InterPro:IPR016040InterPro:IPR020904iPTMnet:P0DKC5KEGG:ath:AT5G50600
KEGG:ath:AT5G50700PANTHER:PTHR24322PaxDb:P0DKC5Pfam:P0DKC5
Pfam:P0DKC6Pfam:PF00106PhylomeDB:P0DKC5PRIDE:P0DKC5
PRINTS:PR00080PRINTS:PR00081PRO:PR:P0DKC5PROSITE:PS00061
ProteinModelPortal:P0DKC5Proteomes:UP000006548Reactome:R-ATH-194002RefSeq:NP_568742.1
RefSeq:NP_680418.1scanprosite:PS00061SMR:P0DKC5STRING:3702.AT5G50700.1
SUPFAM:SSF51735TAIR:AT5G50600tair10-symbols:ATHSD1tair10-symbols:HSD1
TMHMM:TMhelixUniGene:At.67731UniGene:At.7139UniGene:At.72895
UniProt:P0DKC5UniProt:P0DKC6
Coordinates (TAIR10) chr5:-:20589917..20591653
Molecular Weight (calculated) 39089.10 Da
IEP (calculated) 6.15
GRAVY (calculated) 0.03
Length 349 amino acids
Sequence (TAIR10)
(BLAST)
001: MELINDFLNL TAPFFTFFGL CFFLPPFYFF KFLQSIFSTI FSENLYGKVV LITGASSGIG EQLAYEYACR GACLALTARR KNRLEEVAEI ARELGSPNVV
101: TVHADVSKPD DCRRIVDDTI THFGRLDHLV NNAGMTQISM FENIEDITRT KAVLDTNFWG SVYTTRAALP YLRQSNGKIV AMSSSAAWLT APRMSFYNAS
201: KAALLSFFET MRIELGGDVH ITIVTPGYIE SELTQGKYFS GEGELIVNQD MRDVQVGPFP VASASGCAKS IVNGVCRKQR YVTEPSWFKV TYLWKVLCPE
301: LIEWGCRLLY MTGTGMSEDT ALNKRIMDIP GVRSTLYPES IRTPEIKSD
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)