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AT5G46210.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
cytosol 0.846
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : cullin4
Curator
Summary (TAIR10)
Arabidopsis CULLIN4 (CUL4) forms an E3 ubiquitin ligase with the CDD complex and a common catalytic subunit RBX1 in mediating light control of development. This CUL4-based E3 ligase is essential for the repression of photomorphogenesis. The partial loss of CUL4 function resulted in a constitutive photomorphogenic phenotype with respect to morphogenesis and light-regulated gene expression. CUL4 exhibits a synergistic genetic interaction with COP10 and DET1.
Computational
Description (TAIR10)
cullin4 (CUL4); CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Cullin homology (InterPro:IPR016158), Cullin protein, neddylation domain (InterPro:IPR019559), Cullin, N-terminal (InterPro:IPR001373), Cullin, conserved site (InterPro:IPR016157), Cullin repeat-like-containing domain (InterPro:IPR016159); BEST Arabidopsis thaliana protein match is: cullin 3B (TAIR:AT1G69670.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
Protein Annotations
BioGrid:19912BRENDA:2.3.2.B10DIP:DIP-40462NeggNOG:COG5647eggNOG:KOG2167EMBL:AB025620EMBL:AJ318018
EMBL:AY084267EMBL:AY091113EMBL:CP002688EnsemblPlants:AT5G46210EnsemblPlants:AT5G46210.1entrez:834663Gene3D:1.10.10.10
GeneID:834663Genevisible:Q8LGH4GO:GO:0000151GO:GO:0000209GO:GO:0005634GO:GO:0005829GO:GO:0006281
GO:GO:0009640GO:GO:0009738GO:GO:0009755GO:GO:0009908GO:GO:0010100GO:GO:0010154GO:GO:0010182
GO:GO:0031625GO:GO:0042787GO:GO:0048366GO:GO:0048367GO:GO:0048575GO:GO:0048825GO:GO:0080008
Gramene:AT5G46210.1hmmpanther:PTHR11932hmmpanther:PTHR11932:SF27HOGENOM:HOG000176712InParanoid:Q8LGH4IntAct:Q8LGH4InterPro:IPR001373
InterPro:IPR011991InterPro:IPR016157InterPro:IPR016158InterPro:IPR016159InterPro:IPR019559iPTMnet:Q8LGH4KEGG:ath:AT5G46210
KO:K10609MINT:MINT-8141125OMA:FTCNDDFPaxDb:Q8LGH4Pfam:PF00888Pfam:PF10557Pfam:Q8LGH4
Pfscan:PS50069PhylomeDB:Q8LGH4PRIDE:Q8LGH4PRO:PR:Q8LGH4PROSITE:PS01256PROSITE:PS50069ProteinModelPortal:Q8LGH4
Proteomes:UP000006548Reactome:R-ATH-110314Reactome:R-ATH-5696394Reactome:R-ATH-5696395Reactome:R-ATH-5696400Reactome:R-ATH-6781823Reactome:R-ATH-6782135
Reactome:R-ATH-6782210RefSeq:NP_568658.1scanprosite:PS01256SMART:SM00182SMART:SM00884SMR:Q8LGH4STRING:3702.AT5G46210.1
SUPFAM:SSF46785SUPFAM:SSF74788SUPFAM:SSF75632TAIR:AT5G46210tair10-symbols:ATCUL4tair10-symbols:CUL4UniGene:At.20972
UniPathway:UPA00143UniProt:Q8LGH4
Coordinates (TAIR10) chr5:-:18731569..18736653
Molecular Weight (calculated) 91476.50 Da
IEP (calculated) 8.18
GRAVY (calculated) -0.45
Length 792 amino acids
Sequence (TAIR10)
(BLAST)
001: MSLPTKRSTF SAASASDDSS YSSPPMKKAK NDLHHSPQHP NTADKVVGFH MEEDPTPAAA NLSRKKATLP QPTKKFVIKL NKAKPTLPTN FEENTWEKLQ
101: SAIRAIFLKK KISFDLESLY QAVDNLCLHK LDGKLYDQIE KECEEHISAA LQSLVGQNTD LTVFLSRVEK CWQDFCDQML MIRSIALTLD RKYVIQNPNV
201: RSLWEMGLQL FRKHLSLAPE VEQRTVKGLL SMIEKERLAE AVNRTLLSHL LKMFTALGIY MESFEKPFLE GTSEFYAAEG MKYMQQSDVP EYLKHVEGRL
301: HEENERCILY IDAVTRKPLI TTVERQLLER HILVVLEKGF TTLMDGRRTE DLQRMQTLFS RVNALESLRQ ALSSYVRKTG QKIVMDEEKD KDMVQSLLDF
401: KASLDIIWEE SFYKNESFGN TIKDSFEHLI NLRQNRPAEL IAKFLDEKLR AGNKGTSEEE LESVLEKVLV LFRFIQGKDV FEAFYKKDLA KRLLLGKSAS
501: IDAEKSMISK LKTECGSQFT NKLEGMFKDI ELSKEINESF KQSSQARTKL PSGIEMSVHV LTTGYWPTYP PMDVKLPHEL NVYQDIFKEF YLSKYSGRRL
601: MWQNSLGHCV LKADFSKGKK ELAVSLFQAV VLMLFNDAMK LSFEDIKDST SIEDKELRRT LQSLACGKVR VLQKNPKGRD VEDGDEFEFN DEFAAPLYRI
701: KVNAIQMKET VEENTSTTER VFQDRQYQID AAIVRIMKTR KVLSHTLLIT ELFQQLKFPI KPADLKKRIE SLIDREYLER EKSNPQIYNY LA
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)