AT5G16850.1
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Subcellular Consensus
(Prediction and Experimental) min:  :max.
SUBAcon:nucleus 1.000 ASURE: nucleus What is SUBAcon? |
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| Experimental Localisations and PPI |
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SUBAcon links
AGI-AGI relationships |
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| Description (TAIR10) | protein_coding : telomerase reverse transcriptase | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Curator Summary (TAIR10) |
Encodes the catalytic subunit of telomerase reverse transcriptase. Involved in telomere homeostasis. Homozygous double mutants with ATR show gross morphological defects over a period of generations. TERT shows Class II telomerase activity in vitro, indicating that it can initiate de novo telomerase synthesis on non-telomeric DNA, often using a preferred position within the telomerase-bound RNA. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Computational Description (TAIR10) |
telomerase reverse transcriptase (TERT); FUNCTIONS IN: telomerase activity, telomeric template RNA reverse transcriptase activity; INVOLVED IN: nucleolus organization, telomere maintenance via telomerase, chromosome organization, chromosome localization; LOCATED IN: nucleus; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: Telomere reverse transcriptase (InterPro:IPR003545), RNA-directed DNA polymerase (reverse transcriptase) (InterPro:IPR000477), Telomerase ribonucleoprotein complex - RNA-binding domain (InterPro:IPR021891); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink). | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Annotations |
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| Coordinates (TAIR10) | chr5:-:5538323..5543444 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Molecular Weight (calculated) | 130587.00 Da | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| IEP (calculated) | 10.05 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| GRAVY (calculated) | -0.42 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Length | 1123 amino acids | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sequence (TAIR10) (BLAST) |
0001: MPRKPRHRVP EILWRLFGNR ARNLNDAIVD LIPNRNIQPE QCRCRGQGCL GCSSDKPAFL LRSDDPIHYR KLLHRCFVVL HEQTPPLLDF SPTSWWSQRE 0101: IVERIIEMMQ SGCDCQNVIC ARYDKYDQSS PILELLTSSS WEFLLKRVGH DVMVYLLQQT SIFLPLLGKK HQQVSGPPLC IKHKRTLSVH ENKRKRDDNV 0201: QPPTKRQWLS SAVDDCPKDD SATITPIVGE DVDQHREKKT TKRSRIYLKR RRKQRKVNFK KVDCNAPCIT PSTNGKVSTG NDEMNLHIGI NGSLTDFVKQ 0301: AKQVKRNKNF KFGLSETYSV IPPNHILKTL RPNCSDSKLL MNHIFGEVNV WSTTPSHGKG NCPSGSICLY HSLLKSLKNL IGKTKSSHLK MLLDKHCPVL 0401: LLQEDALKSG TTSQSSRRQK ADKLPHGSSS SQTGKPKCPS VEERKLYCTN DQVVSFIWAI CRYIVPESLL GTTHQMRVLR KNIAWFVSRR RNEKCTVNQF 0501: LHKVKPSDFP FFARKELCCM VNGHELQSES IRSTQQMLCT KWISWLFLEI VKKLVHFNFY ATESQGGRLN IYYYRKRSWE RLISKEISKA LDGYVLVDDA 0601: EAESSRKKLS KFRFLPKANG VRMVLDFSSS SRSQSLRDTH AVLKDIQLKE PDVLGSSVFD HDDFYRNLCP YLIHLRSQSG ELPPLYFVVA DVFKAFDSVD 0701: QGKLLHVIQS FLKDEYILNR CRLVCCGKRS NWVNKILVSS DKNSNFSRFT STVPYNALQS IVVDKGENHR VRKKDLMVWI GNMLKNNMLQ LDKSFYVQIA 0801: GIPQGHRLSS LLCCFYYGHL ERTLIYPFLE EASKDVSSKE CSREEELIIP TSYKLLRFID DYLFVSTSRD QASSFYHRLK HGFKDYNCFM NETKFCINFE 0901: DKEEHRCSSN RMFVGDNGVP FVRWTGLLIN SRTFEVQVDY TRYLSGHISS TFSVAWQNKP VRNLRQKLCY FLVPKCHPIL FDSNINSGEI VRLNIYQIFL 1001: LAAMKFHCYV YEVSRFWKLH PQTLFKFITI SVRYMFRLIN RRVRRINTGS SFRPVLKLYK EEVIWLGLDA YIQVLKKKNS RYRMLLIYLK SALSKHSLSQ 1101: QLSSELRYAT DRSNSSSLWK LNY |
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| See Also |
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Citation
If you find this resource useful please cite one of the following publications:
Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)
Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)