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AT5G13960.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
nucleus 1.000
ASURE: nucleus
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : SU(VAR)3-9 homolog 4
Curator
Summary (TAIR10)
Encodes a histone 3 lysine 9 specific methyltransferase involved in the maintenance of DNA methylation. SUVH4/KYP is a SU(VAR)3-9 homolog, a SET domain protein. Known SET domain proteins are involved in epigenetic control of gene expression. There are 10 SUVH genes in Arabidopsis and members of this subfamily of the SET proteins have an additional conserved SRA domain. In kyp mutants, there is a loss of CpNpG methylation. The protein was shown to bind to methylated cytosines of CG, CNG and CNN motifs via its SRA domain but has a preference for the latter two. There is also evidence that KYP/SUVH4 might be involved in the telomerase-independent process known as Alternative Lengthening of Telomeres.
Computational
Description (TAIR10)
SU(VAR)3-9 homolog 4 (SUVH4); FUNCTIONS IN: double-stranded methylated DNA binding, methyl-CpNpG binding, methyl-CpG binding, histone methyltransferase activity (H3-K9 specific), methyl-CpNpN binding; INVOLVED IN: maintenance of DNA methylation, histone methylation, peptidyl-lysine methylation, histone H3-K9 methylation; LOCATED IN: nucleus; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: SET domain (InterPro:IPR001214), SRA-YDG (InterPro:IPR003105), Pre-SET domain (InterPro:IPR007728), Post-SET domain (InterPro:IPR003616); BEST Arabidopsis thaliana protein match is: SU(VAR)3-9 homolog 6 (TAIR:AT2G22740.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT5G13960-MONOMERBioGrid:16522EC:2.1.1.43eggNOG:COG2940eggNOG:COG3440eggNOG:KOG1082EMBL:AB005230
EMBL:AF344447EMBL:AF538715EMBL:BT002313EMBL:CP002688EnsemblPlants:AT5G13960EnsemblPlants:AT5G13960.1entrez:831244
Gene3D:2.30.280.10GeneID:831244Genevisible:Q8GZB6GO:GO:0000775GO:GO:0005634GO:GO:0008270GO:GO:0008327
GO:GO:0010216GO:GO:0010385GO:GO:0010428GO:GO:0010429GO:GO:0016571GO:GO:0018022GO:GO:0046974
GO:GO:0051567Gramene:AT5G13960.1hmmpanther:PTHR22884hmmpanther:PTHR22884:SF352HOGENOM:HOG000238382InParanoid:Q8GZB6InterPro:IPR001214
InterPro:IPR003105InterPro:IPR003616InterPro:IPR007728InterPro:IPR015947InterPro:IPR025794KEGG:ath:AT5G13960KO:K11420
OMA:DTELHEKPaxDb:Q8GZB6PDB:4QENPDB:4QEOPDB:4QEPPDBsum:4QENPDBsum:4QEO
PDBsum:4QEPPfam:PF00856Pfam:PF02182Pfam:PF05033Pfam:Q8GZB6Pfscan:PS50280Pfscan:PS50867
Pfscan:PS50868Pfscan:PS51015Pfscan:PS51575PhylomeDB:Q8GZB6PRIDE:Q8GZB6PRO:PR:Q8GZB6PROSITE:PS50280
PROSITE:PS50867PROSITE:PS50868PROSITE:PS51015PROSITE:PS51575ProteinModelPortal:Q8GZB6Proteomes:UP000006548RefSeq:NP_196900.1
SMART:SM00317SMART:SM00466SMART:SM00468SMR:Q8GZB6STRING:3702.AT5G13960.1SUPFAM:SSF82199SUPFAM:SSF88697
TAIR:AT5G13960tair10-symbols:KYPtair10-symbols:SDG33tair10-symbols:SUVH4UniGene:At.8330UniProt:Q8GZB6
Coordinates (TAIR10) chr5:+:4501688..4505979
Molecular Weight (calculated) 70059.70 Da
IEP (calculated) 8.63
GRAVY (calculated) -0.51
Length 624 amino acids
Sequence (TAIR10)
(BLAST)
001: MAGKRKRANA PDQTERRSSV RVQKVRQKAL DEKARLVQER VKLLSDRKSE ICVDDTELHE KEEENVDGSP KRRSPPKLTA MQKGKQKLSV SLNGKDVNLE
101: PHLKVTKCLR LFNKQYLLCV QAKLSRPDLK GVTEMIKAKA ILYPRKIIGD LPGIDVGHRF FSRAEMCAVG FHNHWLNGID YMSMEYEKEY SNYKLPLAVS
201: IVMSGQYEDD LDNADTVTYT GQGGHNLTGN KRQIKDQLLE RGNLALKHCC EYNVPVRVTR GHNCKSSYTK RVYTYDGLYK VEKFWAQKGV SGFTVYKYRL
301: KRLEGQPELT TDQVNFVAGR IPTSTSEIEG LVCEDISGGL EFKGIPATNR VDDSPVSPTS GFTYIKSLII EPNVIIPKSS TGCNCRGSCT DSKKCACAKL
401: NGGNFPYVDL NDGRLIESRD VVFECGPHCG CGPKCVNRTS QKRLRFNLEV FRSAKKGWAV RSWEYIPAGS PVCEYIGVVR RTADVDTISD NEYIFEIDCQ
501: QTMQGLGGRQ RRLRDVAVPM NNGVSQSSED ENAPEFCIDA GSTGNFARFI NHSCEPNLFV QCVLSSHQDI RLARVVLFAA DNISPMQELT YDYGYALDSV
601: HGPDGKVKQL ACYCGALNCR KRLY
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)