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AT5G13570.1
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
cytosol 1.000
ASURE: cytosol
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : decapping 2
Curator
Summary (TAIR10)
Encodes DCP2 with mRNA decapping activity. DCP2 forms a mRNA decapping complex with DCP1 (At1g08370) and VCS (VARICOSE) (At3g13300). Recombinant DCP2 is enzymatically active in vitro, generating from capped mRNAs m7GDP, and 5’-phosphorylated mRNAs. DCP1, DCP2 and VCS colocalize in cytoplasmic loci, which are putative Arabidopsis mRNA processing bodies. Null mutants of DCP1, DCP2, and VCS accumulate capped mRNAs with a reduced degradation rate. These mutants also share a similar lethal phenotype at the seedling cotyledon stage, with disorganized veins, swollen root hairs, and altered epidermal cell morphology. The protein was shown by immunoprecipitation not to interact with DCP1.
Computational
Description (TAIR10)
decapping 2 (DCP2); CONTAINS InterPro DOMAIN/s: NUDIX hydrolase domain-like (InterPro:IPR015797), Dcp2, box A (InterPro:IPR007722), NUDIX hydrolase, conserved site (InterPro:IPR020084), NUDIX hydrolase domain (InterPro:IPR000086); Has 901 Blast hits to 899 proteins in 331 species: Archae - 18; Bacteria - 332; Metazoa - 132; Fungi - 156; Plants - 50; Viruses - 11; Other Eukaryotes - 202 (source: NCBI BLink).
Protein Annotations
BioGrid:16479EC:3.6.1.62eggNOG:COG0494eggNOG:KOG2937
EMBL:AB006704EMBL:AK119112EMBL:BT005332EMBL:CP002688
EnsemblPlants:AT5G13570EnsemblPlants:AT5G13570.1entrez:831201Gene3D:3.90.79.10
GeneID:831201Genevisible:Q8GW31GO:GO:0000287GO:GO:0000932
GO:GO:0003723GO:GO:0005524GO:GO:0006397GO:GO:0009791
GO:GO:0010072GO:GO:0016787GO:GO:0030145hmmpanther:PTHR23114
HOGENOM:HOG000005974InParanoid:Q8GW31IntAct:Q8GW31InterPro:IPR000086
InterPro:IPR007722InterPro:IPR015797InterPro:IPR020084KEGG:ath:AT5G13570
KO:K12613MINT:MINT-8393471OMA:ESHNTKPPaxDb:Q8GW31
Pfam:PF00293Pfam:PF05026Pfam:Q8GW31Pfscan:PS51462
PhylomeDB:Q8GW31PRIDE:Q8GW31PRO:PR:Q8GW31PROSITE:PS00893
PROSITE:PS51462ProteinModelPortal:Q8GW31Proteomes:UP000006548Reactome:R-ATH-430039
Reactome:R-ATH-450604RefSeq:NP_001190304.1RefSeq:NP_196861.2scanprosite:PS00893
SMART:SM01125SMR:Q8GW31STRING:3702.AT5G13570.2SUPFAM:0051715
SUPFAM:SSF140586SUPFAM:SSF55811TAIR:AT5G13570tair10-symbols:ATDCP2
tair10-symbols:DCP2tair10-symbols:TDTUniGene:At.32052UniProt:Q8GW31
Coordinates (TAIR10) chr5:+:4367532..4369992
Molecular Weight (calculated) 42389.30 Da
IEP (calculated) 8.07
GRAVY (calculated) -0.48
Length 373 amino acids
Sequence (TAIR10)
(BLAST)
001: MSGLHRSSSS SKNIGNCLPS KELLDDLCSR FVLNVPEEDQ QSFERILFLV EYAYWYYEDN AVENDPKLKS LSLKEFTSLL FNSCDVLRPY VTHIDDIFKD
101: FTSYKCRVPV TGAIILDETY ERCLLVKGWK GSSWSFPRGK KSKDEEDHAC AIREVLEETG FDVSKLLKRE EYIEFVFRQQ RVRLYIVAGV TEDTVFAPLT
201: KKEISEITWH RLDHLQPASN EVITHGVSGL KLYMVAPFLS SLKSWILKHP SPVARRPNKP LKALCVWNAR TSVGGNGTAT VESQNRKSEL RTTTMESNSR
301: KPELKRTTME SHSTKPELRK GTMESHNTTA TVESHNTKPV VDHSQDIKPG GSFINFKFNQ SVILQALESG NSA
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)