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AT5G10480.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
endoplasmic reticulum 1.000
What is SUBAcon?
What is ASURE?
SUBAcon computations
Predictors External Curations
AmiGO : cytosol 16698944
AmiGO : cytosol 18799749
AmiGO : nucleus 16698944
SwissProt : nucleus 16381842
SwissProt : cytosol 16381842
SwissProt : plasma membrane 16381842
TAIR : cytosol 16698944
TAIR : nucleus 16698944
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:25900983 (2015): Golgi
  • PMID:25900983 (2015): Golgi Golgi apparatus Golgi membrane
  • PMID:25900983 (2015): Golgi trans-Golgi network
  • PMID:25900983 (2015): Golgi trans-Golgi network early endosome
  • PMID:25900983 (2015): Golgi trans-Golgi network multivesicular body
  • PMID:25641898 (2015): plasma membrane
  • PMID:22923678 (2012): endoplasmic reticulum
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : Protein-tyrosine phosphatase-like, PTPLA
Curator
Summary (TAIR10)
Protein tyrosine phosphatase-like involved in cell division and differentiation. Interacts with CDKA;1 only in its phosphorylated form, preventing dephosphorylation. Overexpression slowed down cell division in suspension cell cultures at the G2-to-M transition and early mitosis and inhibited Arabidopsis seedling growth. Localized in the cytoplasm of dividing cells but moved into the nucleus upon cell differentiation. Based on complementation of yeast mutant PAS2 has acyl-CoA dehydratase activity. It interacts with CER10, a component of the microsomal fatty acid elongase complex, suggesting a role in synthesis of VLCFAs (very long chain fatty acids).
Computational
Description (TAIR10)
PASTICCINO 2 (PAS2); CONTAINS InterPro DOMAIN/s: Protein-tyrosine phosphatase-like, PTPLA (InterPro:IPR007482); BEST Arabidopsis thaliana protein match is: Protein-tyrosine phosphatase-like, PTPLA (TAIR:AT5G59770.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT5G10480-MONOMERBioCyc:ARA:GQT-1804-MONOMERBioCyc:ARA:GQT-1805-MONOMERBioCyc:MetaCyc:AT5G10480-MONOMERBioGrid:16190BRENDA:4.2.1.134EC:4.2.1.134
eggNOG:COG5198eggNOG:KOG3187EMBL:AJ506746EMBL:AL353995EMBL:AY047708EMBL:AY065090EMBL:BT006269
EMBL:CP002688EnsemblPlants:AT5G10480EnsemblPlants:AT5G10480.1entrez:830912ExpressionAtlas:Q8VZB2GeneID:830912Genevisible:Q8VZB2
GO:GO:0005634GO:GO:0005789GO:GO:0006633GO:GO:0007275GO:GO:0016021GO:GO:0016829gramene_pathway:4.2.1.116
gramene_pathway:4.2.1.17gramene_pathway:ILEUDEG-PWYgramene_pathway:PWY-3941gramene_pathway:PWY-5136gramene_pathway:PWY-5138gramene_pathway:VALDEG-PWYhmmpanther:PTHR11035
HOGENOM:HOG000190538InParanoid:Q8VZB2InterPro:IPR007482KEGG:00062+4.2.1.134KEGG:ath:AT5G10480KO:K10703PANTHER:PTHR11035
PaxDb:Q8VZB2Pfam:PF04387Pfam:Q8VZB2PhylomeDB:Q8VZB2PIR:T49991PRIDE:Q8VZB2PRO:PR:Q8VZB2
ProteinModelPortal:Q8VZB2Proteomes:UP000006548Reactome:R-ATH-75876RefSeq:NP_001078566.1RefSeq:NP_196610.2STRING:3702.AT5G10480.3TAIR:AT5G10480
tair10-symbols:PAS2tair10-symbols:PEPTMHMM:TMhelixUniGene:At.22730UniPathway:UPA00094UniProt:Q8VZB2
Coordinates (TAIR10) chr5:-:3298047..3300048
Molecular Weight (calculated) 25328.20 Da
IEP (calculated) 9.84
GRAVY (calculated) 0.45
Length 221 amino acids
Sequence (TAIR10)
(BLAST)
001: MAGFLSVVRR VYLTLYNWIV FAGWAQVLYL AITTLKETGY ENVYDAIEKP LQLAQTAAVL EILHGLVGLV RSPVSATLPQ IGSRLFLTWG ILYSFPEVRS
101: HFLVTSLVIS WSITEIIRYS FFGFKEALGF APSWHLWLRY SSFLLLYPTG ITSEVGLIYL ALPHIKTSEM YSVRMPNILN FSFDFFYATI LVLAIYVPGS
201: PHMYRYMLGQ RKRALSKSKR E
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)