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AT5G06460.1
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
nucleus 0.968
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:28865150 (2017): extracellular region plant-type cell wall
  • PMID:25900983 (2015): Golgi
  • PMID:25900983 (2015): Golgi trans-Golgi network
  • PMID:25900983 (2015): Golgi trans-Golgi network multivesicular body
  • PMID:21166475 (2011): cytosol
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : ubiquitin activating enzyme 2
Curator
Summary (TAIR10)
Encodes a ubiquitin-activating enzyme (E1), involved in the first step in conjugating multiple ubiquitins to proteins targeted for degradation. Gene is expressed in most tissues examined.
Computational
Description (TAIR10)
ubiquitin activating enzyme 2 (UBA 2); FUNCTIONS IN: ubiquitin-protein ligase activity, ubiquitin activating enzyme activity; INVOLVED IN: protein ubiquitination, ubiquitin-dependent protein catabolic process; LOCATED IN: nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Ubiquitin-activating enzyme, E1, active site (InterPro:IPR018074), Ubiquitin-activating enzyme, E1 (InterPro:IPR018075), Ubiquitin-activating enzyme e1, C-terminal (InterPro:IPR018965), Ubiquitin-activating enzyme repeat (InterPro:IPR000127), Ubiquitin-activating enzyme (InterPro:IPR019572), UBA/THIF-type NAD/FAD binding fold (InterPro:IPR000594), Molybdenum cofactor biosynthesis, MoeB (InterPro:IPR009036), NAD(P)-binding domain (InterPro:IPR016040), Ubiquitin-activating enzyme, E1-like (InterPro:IPR000011); BEST Arabidopsis thaliana protein match is: ubiquitin-activating enzyme 1 (TAIR:AT2G30110.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
Protein Annotations
BRENDA:2.3.2.B5BRENDA:6.2.1.B9EC:6.2.1.45eggNOG:COG0476
eggNOG:KOG2012EMBL:AB006700EMBL:CP002688EMBL:U40566
EnsemblPlants:AT5G06460EnsemblPlants:AT5G06460.1entrez:830534Gene3D:1.10.10.520
Gene3D:3.40.50.720GeneID:830534Genevisible:P92974GO:GO:0004842
GO:GO:0005524GO:GO:0005634GO:GO:0005829GO:GO:0008641
GO:GO:0016567GO:GO:0016881Gramene:AT5G06460.1hmmpanther:PTHR10953
hmmpanther:PTHR10953:SF164HOGENOM:HOG000167329InParanoid:P92974InterPro:IPR000011
InterPro:IPR000594InterPro:IPR016040InterPro:IPR018074InterPro:IPR018075
InterPro:IPR018965InterPro:IPR019572InterPro:IPR023318InterPro:IPR032418
InterPro:IPR032420InterPro:IPR033127iPTMnet:P92974KEGG:00220+6.3.2.-
KEGG:00261+6.3.2.-KEGG:00380+6.3.2.-KEGG:ath:AT5G06460KO:K03178
OMA:ECAPRNCPaxDb:P92974Pfam:P92974Pfam:PF00899
Pfam:PF09358Pfam:PF10585Pfam:PF16190Pfam:PF16191
PhylomeDB:P92974PRIDE:P92974PRINTS:PR01849PRO:PR:P92974
PROSITE:PS00536PROSITE:PS00865ProteinModelPortal:P92974Proteomes:UP000006548
Reactome:R-ATH-1169408RefSeq:NP_568168.1scanprosite:PS00536scanprosite:PS00865
SMART:SM00985SMR:P92974STRING:3702.AT5G06460.1SUPFAM:SSF69572
TAIR:AT5G06460tair10-symbols:ATUBA2tair10-symbols:UBA 2TIGRfam:TIGR01408
TIGRFAMs:TIGR01408UniGene:At.27859UniGene:At.65020UniPathway:UPA00143
unipathway:UPA00885UniProt:P92974
Coordinates (TAIR10) chr5:+:1970239..1974382
Molecular Weight (calculated) 119630.00 Da
IEP (calculated) 4.92
GRAVY (calculated) -0.22
Length 1077 amino acids
Sequence (TAIR10)
(BLAST)
0001: MEPFVVKENI IASASSPMKK RRIDHTESAD GSAINASNSS SIGLNNSIGG NDTVMSMAEF GNDNSNNQEI DEDLHSRQLA VYGRETMRKL FASNVLISGM
0101: QGLGVEIAKN IILAGVKSVT LHDENVVELW DLSSNFVFTE EDIGKNRALA SVHKLQELNN AVAVSTLTGK LTKEQLSDFQ VVVFVDISFE KATEIDDYCH
0201: SHQPPIAFIK ADVRGLFGSL FCDFGPHFTV LDVDGEEPHS GIIASVSNEN PGFVSCVDDE RLEFEDGNLV VFSEVEGMTE LNDGKPRKIK NVKPFSFTLE
0301: EDTSSYGQYM KGGIVTQVKQ PKVLNFKPLR EALKDPGDFL LSDFSKFDRP PLLHLAFQAL DRFSSQAGRF PFAGSEEDAQ KLVEIAVDIN EGLGDARLED
0401: VNSKLLRHLA FGSRAVLNPM AAMFGGIVGQ EVVKACSGKF HPIFQFFYFD SVESLPKEPL DASEFRPQNS RYDAQISVFG STLQKKLEDA RVFVVGAGAL
0501: GCEFLKNLAL MGVSCGTQGK LTVTDDDVIE KSNLSRQFLF RDWNIGQAKS TVAATAAAGI NSRLNIDALQ NRVGPETENV FDDSFWENLT VVVNALDNVT
0601: ARLYVDSRCV YFQKPLLESG TLGAKCNTQM VIPHLTENYG ASRDPPEKQA PMCTVHSFPH NIDHCLTWAR SEFEGLLEKT PAEVNAYLSD PVEYMKAMRT
0701: AGDAQARDTL GRVVECLEKE KCNSFQDCIT WARLRFEDYF ANRVKQLCYT FPEDAATSTG APFWSAPKRF PRPLQFSSTD LSHINFVMAA SILRAETFGI
0801: PTPEWAKTRA GLAEAVERVI VPDFEPKKDA TIVTDEKATT LSTASVDDAA VIDELNAKLV RCRMSLQPEF RMKAIQFEKD DDTNYHMDMI AGLANMRARN
0901: YSVPEVDKLK AKFIAGRIIP AIATSTAMAT GFVCLEMYKV LDGSHKVEDY RNTFANLALP LFSMAEPVPP KVVKHQDQSW TVWDRWVMRG NPTLRELLDW
1001: LKEKGLNAYS ISCGSSLLYN SMFSRHKERM NRRVVDLARD VAGVELPAYR RHVDVVVACE DDNDADVDIP LVSVYFA
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)