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AT4G39400.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
plasma membrane 1.000
ASURE: plasma membrane
What is SUBAcon?
What is ASURE?
SUBAcon computations
Predictors External Curations
AmiGO : cytosol 15548744
AmiGO : plasma membrane 10938344
AmiGO : plasma membrane 16618929
AmiGO : plasma membrane 19004783
SwissProt : endoplasmic reticulum 16381842
SwissProt : plasma membrane 16381842
TAIR : cytosol 15548744
TAIR : plasma membrane 10938344
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:26748395 (2016): plasma membrane
  • PMID:22923678 (2012): plasma membrane
  • PMID:22318864 (2012): plasma membrane
  • PMID:18686298 (2008): plant-type vacuole plant-type vacuole membrane
  • PMID:16618929 (2006): plasma membrane
  • PMID:16473966 (2006): plasma membrane
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : Leucine-rich receptor-like protein kinase family protein
Curator
Summary (TAIR10)
Encodes a plasma membrane localized leucine-rich repeat receptor kinase involved in brassinosteroid signal transduction. BRI1 ligand is brassinolide which binds at the extracellular domain. Binding results in phosphorylation of the kinase domain which activates the BRI1 protein leading to BR responses. Residue T-1049 and either S-1044 or T-1045 were essential for kinase function in vitro and normal BRI1 signaling in planta. Although BAK1 and BRI1 alone localize in the plasma membrane, when BAK1 and BRI1 are coexpressed, the heterodimer BAK1/BRI1 they form is localized in the endosome. BRI1 appears to be involved in the autonomous pathway that regulates the transition to flowering, primarily through its effects on FLC expression levels, as uncovered by double mutant analyses. This most likely occurs as a result of BRI1-dependent effects on histone acetylation, but not histone triMeH3K4 methylation, at the FLC locus.
Computational
Description (TAIR10)
BRASSINOSTEROID INSENSITIVE 1 (BRI1); FUNCTIONS IN: in 6 functions; INVOLVED IN: in 9 processes; LOCATED IN: endosome, plasma membrane, protein complex; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: BRI1 like (TAIR:AT1G55610.2); Has 214988 Blast hits to 139206 proteins in 4645 species: Archae - 193; Bacteria - 21464; Metazoa - 65624; Fungi - 10774; Plants - 90532; Viruses - 410; Other Eukaryotes - 25991 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT4G39400-MONOMERBioGrid:15375DIP:DIP-45997NEC:2.7.10.1EC:2.7.11.1eggNOG:COG0515eggNOG:COG4886
eggNOG:ENOG410IF0BEMBL:AF017056EMBL:AL078620EMBL:AL161595EMBL:CP002687EMBL:FJ708766EnsemblPlants:AT4G39400
EnsemblPlants:AT4G39400.1entrez:830095EvolutionaryTrace:O22476Gene3D:2.60.120.200Gene3D:3.80.10.10GeneID:830095Genevisible:O22476
GO:GO:0004672GO:GO:0004674GO:GO:0004714GO:GO:0005496GO:GO:0005524GO:GO:0005768GO:GO:0005886
GO:GO:0009729GO:GO:0009742GO:GO:0009911GO:GO:0010008GO:GO:0010224GO:GO:0010268GO:GO:0010584
GO:GO:0016021GO:GO:0042802GO:GO:0042803GO:GO:0046982GO:GO:0048366GO:GO:0048657GO:GO:0060548
GO:GO:1900140Gramene:AT4G39400.1hmmpanther:PTHR27000hmmpanther:PTHR27000:SF220HOGENOM:HOG000116551InParanoid:O22476IntAct:O22476
InterPro:IPR000719InterPro:IPR001611InterPro:IPR003591InterPro:IPR008271InterPro:IPR011009InterPro:IPR013210InterPro:IPR013320
InterPro:IPR017441InterPro:IPR025875InterPro:IPR032675iPTMnet:O22476KEGG:ath:AT4G39400KO:K13415OMA:QPTDSAD
PaxDb:O22476PDB:3RGXPDB:3RGZPDB:3RIZPDB:3RJ0PDB:4LSAPDB:4LSX
PDB:4M7EPDB:4OA2PDB:4OA6PDB:4OA9PDB:4OABPDB:4OACPDB:4OH4
PDB:4Q5JPDBsum:3RGXPDBsum:3RGZPDBsum:3RIZPDBsum:3RJ0PDBsum:4LSAPDBsum:4LSX
PDBsum:4M7EPDBsum:4OA2PDBsum:4OA6PDBsum:4OA9PDBsum:4OABPDBsum:4OACPDBsum:4OH4
PDBsum:4Q5JPfam:O22476Pfam:PF00069Pfam:PF00560Pfam:PF08263Pfam:PF12799Pfam:PF13855
Pfscan:PS50011PhylomeDB:O22476PIR:T09356PRIDE:O22476PRO:PR:O22476PROSITE:PS00107PROSITE:PS00108
PROSITE:PS50011ProteinModelPortal:O22476Proteomes:UP000006548RefSeq:NP_195650.1scanprosite:PS00107scanprosite:PS00108SMART:SM00220
SMART:SM00369SMR:O22476STRING:3702.AT4G39400.1SUPFAM:SSF52047SUPFAM:SSF52058SUPFAM:SSF56112TAIR:AT4G39400
tair10-symbols:ATBRI1tair10-symbols:BIN1tair10-symbols:BRI1tair10-symbols:CBB2tair10-symbols:DWF2TMHMM:TMhelixUniGene:At.27898
UniGene:At.69020UniProt:O22476
Coordinates (TAIR10) chr4:+:18324826..18328416
Molecular Weight (calculated) 130551.00 Da
IEP (calculated) 6.38
GRAVY (calculated) -0.09
Length 1196 amino acids
Sequence (TAIR10)
(BLAST)
0001: MKTFSSFFLS VTTLFFFSFF SLSFQASPSQ SLYREIHQLI SFKDVLPDKN LLPDWSSNKN PCTFDGVTCR DDKVTSIDLS SKPLNVGFSA VSSSLLSLTG
0101: LESLFLSNSH INGSVSGFKC SASLTSLDLS RNSLSGPVTT LTSLGSCSGL KFLNVSSNTL DFPGKVSGGL KLNSLEVLDL SANSISGANV VGWVLSDGCG
0201: ELKHLAISGN KISGDVDVSR CVNLEFLDVS SNNFSTGIPF LGDCSALQHL DISGNKLSGD FSRAISTCTE LKLLNISSNQ FVGPIPPLPL KSLQYLSLAE
0301: NKFTGEIPDF LSGACDTLTG LDLSGNHFYG AVPPFFGSCS LLESLALSSN NFSGELPMDT LLKMRGLKVL DLSFNEFSGE LPESLTNLSA SLLTLDLSSN
0401: NFSGPILPNL CQNPKNTLQE LYLQNNGFTG KIPPTLSNCS ELVSLHLSFN YLSGTIPSSL GSLSKLRDLK LWLNMLEGEI PQELMYVKTL ETLILDFNDL
0501: TGEIPSGLSN CTNLNWISLS NNRLTGEIPK WIGRLENLAI LKLSNNSFSG NIPAELGDCR SLIWLDLNTN LFNGTIPAAM FKQSGKIAAN FIAGKRYVYI
0601: KNDGMKKECH GAGNLLEFQG IRSEQLNRLS TRNPCNITSR VYGGHTSPTF DNNGSMMFLD MSYNMLSGYI PKEIGSMPYL FILNLGHNDI SGSIPDEVGD
0701: LRGLNILDLS SNKLDGRIPQ AMSALTMLTE IDLSNNNLSG PIPEMGQFET FPPAKFLNNP GLCGYPLPRC DPSNADGYAH HQRSHGRRPA SLAGSVAMGL
0801: LFSFVCIFGL ILVGREMRKR RRKKEAELEM YAEGHGNSGD RTANNTNWKL TGVKEALSIN LAAFEKPLRK LTFADLLQAT NGFHNDSLIG SGGFGDVYKA
0901: ILKDGSAVAI KKLIHVSGQG DREFMAEMET IGKIKHRNLV PLLGYCKVGD ERLLVYEFMK YGSLEDVLHD PKKAGVKLNW STRRKIAIGS ARGLAFLHHN
1001: CSPHIIHRDM KSSNVLLDEN LEARVSDFGM ARLMSAMDTH LSVSTLAGTP GYVPPEYYQS FRCSTKGDVY SYGVVLLELL TGKRPTDSPD FGDNNLVGWV
1101: KQHAKLRISD VFDPELMKED PALEIELLQH LKVAVACLDD RAWRRPTMVQ VMAMFKEIQA GSGIDSQSTI RSIEDGGFST IEMVDMSIKE VPEGKL
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)