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AT4G34350.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
plastid 1.000
ASURE: plastid
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:27122571 (2016): mitochondrion
  • PMID:25900983 (2015): Golgi trans-Golgi network multivesicular body
  • PMID:25900983 (2015): plant-type vacuole plant-type vacuole membrane
  • PMID:24872594 (2014): plastid plastid stroma
  • PMID:24361574 (2014): plastid plastid stroma
  • PMID:21531424 (2011): plastid
  • PMID:20061580 (2010): plastid plastid stroma
  • PMID:18633119 (2008): plastid plastid stroma
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
Curator
Summary (TAIR10)
Arabidopsis ISPH is involved in the plastid nonmevalonate pathway of isoprenoid biosynthesis. It was shown to complement the lethal phenotype of E. coli ispH mutant and is therefore most likely encodes a protein with 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity involved in the last step of mevalonate-independent isopentenyl biosynthesis. Mutant has Albino seedling.
Computational
Description (TAIR10)
4-hydroxy-3-methylbut-2-enyl diphosphate reductase (HDR); FUNCTIONS IN: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity, 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity; INVOLVED IN: response to antibiotic, isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway; LOCATED IN: chloroplast stroma, chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: LytB protein (InterPro:IPR003451); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT4G34350-MONOMER-9581BioCyc:MetaCyc:AT4G34350-MONOMER-9581EC:1.17.7.4eggNOG:COG0761eggNOG:ENOG410IIDHEMBL:AK222055EMBL:AK317707
EMBL:AL035521EMBL:AL161585EMBL:AY042877EMBL:AY081454EMBL:AY168881EMBL:AY883838EMBL:CP002687
EnsemblPlants:AT4G34350EnsemblPlants:AT4G34350.1entrez:829585GeneID:829585Genevisible:Q94B35GO:GO:0009507GO:GO:0009570
GO:GO:0019288GO:GO:0046429GO:GO:0046872GO:GO:0050992GO:GO:0051538GO:GO:0051745Gramene:AT4G34350.1
gramene_pathway:1.17.1.2gramene_pathway:NONMEVIPP-PWYgramene_plant_reactome:1119464gramene_plant_reactome:6874355gramene_plant_reactome:6876481HAMAP:MF_00191hmmpanther:PTHR31619
hmmpanther:PTHR31619:SF2HOGENOM:HOG000240388InParanoid:Q94B35InterPro:IPR003451KEGG:00900+1.17.1.2KEGG:ath:AT4G34350KO:K03527
OMA:AYETRRHPaxDb:Q94B35Pfam:PF02401Pfam:Q94B35PhylomeDB:Q94B35PIR:T04781PRIDE:Q94B35
PRO:PR:Q94B35ProteinModelPortal:Q94B35Proteomes:UP000006548RefSeq:NP_567965.1SMR:Q94B35STRING:3702.AT4G34350.1TAIR:AT4G34350
tair10-symbols:CLB6tair10-symbols:HDRtair10-symbols:ISPHTIGRfam:TIGR00216TIGRFAMs:TIGR00216UniGene:At.2618UniPathway:UPA00056
UniPathway:UPA00059UniProt:Q94B35
Coordinates (TAIR10) chr4:-:16428681..16431038
Molecular Weight (calculated) 52783.80 Da
IEP (calculated) 5.92
GRAVY (calculated) -0.45
Length 466 amino acids
Sequence (TAIR10)
(BLAST)
001: MAVALQFSRL CVRPDTFVRE NHLSGSGSLR RRKALSVRCS SGDENAPSPS VVMDSDFDAK VFRKNLTRSD NYNRKGFGHK EETLKLMNRE YTSDILETLK
101: TNGYTYSWGD VTVKLAKAYG FCWGVERAVQ IAYEARKQFP EERLWITNEI IHNPTVNKRL EDMDVKIIPV EDSKKQFDVV EKDDVVILPA FGAGVDEMYV
201: LNDKKVQIVD TTCPWVTKVW NTVEKHKKGE YTSVIHGKYN HEETIATASF AGKYIIVKNM KEANYVCDYI LGGQYDGSSS TKEEFMEKFK YAISKGFDPD
301: NDLVKVGIAN QTTMLKGETE EIGRLLETTM MRKYGVENVS GHFISFNTIC DATQERQDAI YELVEEKIDL MLVVGGWNSS NTSHLQEISE ARGIPSYWID
401: SEKRIGPGNK IAYKLHYGEL VEKENFLPKG PITIGVTSGA STPDKVVEDA LVKVFDIKRE ELLQLA
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)