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AT4G26970.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
mitochondrion 1.000
ASURE: mitochondrion
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
FP Images

Arabidopsis cell culture (mitochondrial marker)

At4g26970-GFP (AA 1-100)mitochondrial marker-RFPoverlay

Images by Sandra Tanz

Arabidopsis cell culture (plastidal marker)

At4g26970-GFP (AA 1-100)plastidal marker-RFPoverlay

Images by Sandra Tanz
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : aconitase 2
Curator
Summary (TAIR10)
Encodes an aconitase that can catalyze the conversion of citrate to isocitrate through a cis-aconitate intermediate, indicating that it may participate in the TCA cycle and other primary metabolic pathways. The protein is believed to accumulate in the mitochondria and the cytosol. It affects CSD2 (At2g28190 - a superoxide dismutase) transcript levels and may play a role in the response to oxidative stress. One member of the family (ACO1 - At35830) was shown to specifically bind to the 5' UTR of CSD2 in vitro.
Computational
Description (TAIR10)
aconitase 2 (ACO2); FUNCTIONS IN: aconitate hydratase activity, copper ion binding; INVOLVED IN: response to oxidative stress, response to cadmium ion, isocitrate metabolic process, citrate metabolic process; LOCATED IN: cytosol, mitochondrion, chloroplast; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 17 growth stages; CONTAINS InterPro DOMAIN/s: Aconitase family, 4Fe-4S cluster binding site (InterPro:IPR018136), Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha (InterPro:IPR001030), Aconitase A/isopropylmalate dehydratase small subunit, swivel (InterPro:IPR000573), Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2 (InterPro:IPR015932), Aconitase/Iron regulatory protein 2/2-methylisocitrate dehydratase (InterPro:IPR015934), Aconitase/3-isopropylmalate dehydratase, swivel (InterPro:IPR015928), Aconitase-like core (InterPro:IPR015937), Aconitase/iron regulatory protein 2 (InterPro:IPR006249), Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 (InterPro:IPR015931); BEST Arabidopsis thaliana protein match is: aconitase 3 (TAIR:AT2G05710.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
Protein Annotations
BioGrid:14092EC:4.2.1.3eggNOG:COG1048eggNOG:KOG0452EMBL:AL035440EMBL:AL161566EMBL:AY050431
EMBL:BT000492EMBL:CP002687EnsemblPlants:AT4G26970EnsemblPlants:AT4G26970.1entrez:828805Gene3D:3.20.19.10Gene3D:3.30.499.10
Gene3D:3.40.1060.10GeneID:828805Genevisible:Q94A28GO:GO:0003994GO:GO:0005507GO:GO:0005739GO:GO:0005829
GO:GO:0006097GO:GO:0006099GO:GO:0006101GO:GO:0006102GO:GO:0006979GO:GO:0009507GO:GO:0046686
GO:GO:0051539Gramene:AT4G26970.1gramene_pathway:4.2.1.3gramene_pathway:GLYOXYLATE-BYPASSgramene_pathway:PWY-5690gramene_pathway:PWY-6549gramene_pathway:PWYQT-4481
hmmpanther:PTHR11670hmmpanther:PTHR11670:SF37HOGENOM:HOG000025703InParanoid:Q94A28InterPro:IPR000573InterPro:IPR001030InterPro:IPR006249
InterPro:IPR015928InterPro:IPR015931InterPro:IPR015932InterPro:IPR015937InterPro:IPR018136iPTMnet:Q94A28KEGG:00020+4.2.1.3
KEGG:00290+4.2.1.33KEGG:00630+4.2.1.3KEGG:00720+4.2.1.3KEGG:ath:AT4G26970KO:K01681OMA:CSASTRWPANTHER:PTHR11670
PaxDb:Q94A28Pfam:PF00330Pfam:PF00694Pfam:Q94A28PIR:T04820PRIDE:Q94A28PRINTS:PR00415
PRO:PR:Q94A28PROSITE:PS00450PROSITE:PS01244ProteinModelPortal:Q94A28Proteomes:UP000006548RefSeq:NP_567763.2scanprosite:PS00450
scanprosite:PS01244SMR:Q94A28STRING:3702.AT4G26970.1SUPFAM:SSF52016SUPFAM:SSF53732TAIR:AT4G26970tair10-symbols:ACO2
TIGRfam:TIGR01341TIGRFAMs:TIGR01341UniGene:At.22696UniGene:At.48905unipathway:UPA00048UniPathway:UPA00223UniProt:Q94A28
Coordinates (TAIR10) chr4:+:13543077..13548427
Molecular Weight (calculated) 108487.00 Da
IEP (calculated) 7.16
GRAVY (calculated) -0.25
Length 995 amino acids
Sequence (TAIR10)
(BLAST)
001: MYRRATSGVR SASARLSSSL SRIASSETAS VSAPSASSLR NQTNRSKSFS SALRSFRVCS ASTRWSHGGS WGSPASLRAQ ARNSTPVMEK FERKYATMAS
101: EHSYKDILTS LPKPGGGEYG KYYSLPALND PRIDKLPFSV RILLESAIRN CDNYQVTKDD VEKILDWENT STKQVEIAFK PARVILQDFT GVPVLVDLAS
201: MRDAVKNLGS DPSKINPLVP VDLVVDHSIQ VDFARSEDAA QKNLELEFKR NKERFTFLKW GSTAFQNMLV VPPGSGIVHQ VNLEYLGRVV FNSKGFLYPD
301: SVVGTDSHTT MIDGLGVAGW GVGGIEAEAA MLGQPMSMVL PGVVGFKLDG KLKEGVTATD LVLTVTQILR KHGVVGKFVE FYGEGMSELS LADRATIANM
401: SPEYGATMGF FPVDHVTLEY LKLTGRSDET VSMIESYLRA NNMFVDYNEP QQERAYTSYL QLDLGHVEPC ISGPKRPHDR VPLKDMKADW HACLDNPVGF
501: KGFAVPKEKQ EEVVKFSYNG QPAEIKHGSV VIAAITSCTN TSNPSVMIGA ALVAKKASDL GLKVKPWVKT SLAPGSRVVE KYLDRSGLRE SLTKQGFEIV
601: GYGCTTCIGN SGNLDPEVAS AIEGTDIIPA AVLSGNRNFE GRVHPQTRAN YLASPPLVVA YALAGTVDID FEKEPIGTRS DGKSVYLRDV WPSNEEVAQV
701: VQYSVLPSMF KSSYETITEG NPLWNELSAP SSTLYSWDPN STYIHEPPYF KNMTANPPGP REVKDAYCLL NFGDSVTTDH ISPAGNIQKT SPAAKFLMDR
801: GVISEDFNSY GSRRGNDEVM ARGTFANIRI VNKLLKGEVG PNTVHIPTGE KLSVFDAASK YKTAEQDTII LAGAEYGSGS SRDWAAKGPL LLGVKAVIAK
901: SFERIHRSNL AGMGIIPLCF KAGEDAETLG LTGHERYTVH LPTKVSDIRP GQDVTVTTDS GKSFVCTLRF DTEVELAYYD HGGILPYVIR SLSAK
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)