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AT4G23650.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
cytosol 0.999
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:26781341 (2016): plasma membrane
  • PMID:25900983 (2015): plant-type vacuole plant-type vacuole membrane
  • PMID:25900983 (2015): Golgi trans-Golgi network multivesicular body
  • PMID:25900983 (2015): Golgi trans-Golgi network early endosome
  • PMID:25900983 (2015): Golgi trans-Golgi network
  • PMID:25900983 (2015): Golgi Golgi apparatus Golgi membrane
  • PMID:25900983 (2015): Golgi
  • PMID:25641898 (2015): plasma membrane
  • PMID:22923678 (2012): plasma membrane
  • PMID:22318864 (2012): plasma membrane
  • PMID:22215637 (2012): plasma membrane
  • PMID:21166475 (2011): cytosol
  • PMID:20843791 (2010): plasma membrane
  • PMID:19334764 (2009): plasma membrane
  • PMID:17317660 (2007): plasma membrane
  • PMID:16635983 (2006): plasma membrane
  • PMID:16618929 (2006): plasma membrane
  • PMID:15574830 (2004): plasma membrane
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : calcium-dependent protein kinase 6
Curator
Summary (TAIR10)
Encodes calcium dependent protein kinase 3 (CPK3), a member of the Arabidopsis CDPK gene family. CDPKs contain an intrinsic Ca2+-activation domain with four EF hand Ca2+-binding sites. CDPKs protein kinases have been proposed to function in multiple plant signal transduction pathways downstream of [Ca2+]cyt elevations, thus transducing various physiological responses. CPK3 is expressed in both guard cells and mesophyll cells. Functions in guard cell ion channel regulation. ABA and Ca(2+) activation of slow-type anion channels and, interestingly, ABA activation of plasma membrane Ca(2+)-permeable channels were impaired in independent alleles of single and double cpk3cpk6 mutant guard cells. Furthermore, ABA- and Ca(2+)-induced stomatal closing were partially impaired in these cpk3cpk6 mutant alleles. CPK6 is also a member of the Arabidopsis CDPK family.
Computational
Description (TAIR10)
calcium-dependent protein kinase 6 (CDPK6); FUNCTIONS IN: calmodulin-dependent protein kinase activity, protein kinase activity, kinase activity; INVOLVED IN: in 6 processes; LOCATED IN: plasma membrane, vacuole, membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), EF-Hand 1, calcium-binding site (InterPro:IPR018247), Serine/threonine-protein kinase domain (InterPro:IPR002290), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand-like domain (InterPro:IPR011992), EF-hand (InterPro:IPR018248), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), EF-HAND 2 (InterPro:IPR018249), Calcium-dependent protein kinase (InterPro:IPR020642), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: calcium-dependent protein kinase 17 (TAIR:AT5G12180.1); Has 137650 Blast hits to 128872 proteins in 4025 species: Archae - 155; Bacteria - 13983; Metazoa - 52031; Fungi - 17582; Plants - 29890; Viruses - 500; Other Eukaryotes - 23509 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT4G23650-MONOMERBioGrid:13754EC:2.7.11.1eggNOG:ENOG410XRMJeggNOG:KOG0032EMBL:AF385710EMBL:AF446863
EMBL:AL035394EMBL:AL161559EMBL:AY052319EMBL:AY081732EMBL:AY087637EMBL:BT000736EMBL:CP002687
EMBL:U20623EMBL:U20625EnsemblPlants:AT4G23650EnsemblPlants:AT4G23650.1entrez:828465Gene3D:1.10.238.10GeneID:828465
Genevisible:Q42479GO:GO:0004672GO:GO:0004674GO:GO:0004683GO:GO:0005509GO:GO:0005516GO:GO:0005524
GO:GO:0005634GO:GO:0005773GO:GO:0005829GO:GO:0005886GO:GO:0009651GO:GO:0009738GO:GO:0009931
GO:GO:0010119GO:GO:0010359GO:GO:0016020GO:GO:0018105GO:GO:0035556GO:GO:0046777Gramene:AT4G23650.1
hmmpanther:PTHR24349hmmpanther:PTHR24349:SF95HOGENOM:HOG000233030InParanoid:Q42479IntAct:Q42479InterPro:IPR000719InterPro:IPR002048
InterPro:IPR008271InterPro:IPR011009InterPro:IPR011992InterPro:IPR017441InterPro:IPR018247iPTMnet:Q42479KEGG:ath:AT4G23650
KO:K13412ncoils:CoilOMA:CKSIAARPaxDb:Q42479Pfam:PF00069Pfam:PF13499Pfam:Q42479
Pfscan:PS50011Pfscan:PS50222PhylomeDB:Q42479PIR:T05597PRIDE:Q42479PRO:PR:Q42479PROSITE:PS00018
PROSITE:PS00107PROSITE:PS00108PROSITE:PS50011PROSITE:PS50222ProteinModelPortal:Q42479Proteomes:UP000006548RefSeq:NP_194096.1
scanprosite:PS00018scanprosite:PS00107scanprosite:PS00108SMART:SM00054SMART:SM00220SMR:Q42479STRING:3702.AT4G23650.1
SUPFAM:SSF47473SUPFAM:SSF56112TAIR:AT4G23650tair10-symbols:CDPK6tair10-symbols:CPK3UniGene:At.24517UniProt:Q42479
Coordinates (TAIR10) chr4:-:12324967..12327415
Molecular Weight (calculated) 59339.70 Da
IEP (calculated) 6.32
GRAVY (calculated) -0.53
Length 529 amino acids
Sequence (TAIR10)
(BLAST)
001: MGHRHSKSKS SDPPPSSSSS SSGNVVHHVK PAGERRGSSG SGTVGSSGSG TGGSRSTTST QQNGRILGRP MEEVRRTYEF GRELGRGQFG VTYLVTHKET
101: KQQVACKSIP TRRLVHKDDI EDVRREVQIM HHLSGHRNIV DLKGAYEDRH SVNLIMELCE GGELFDRIIS KGLYSERAAA DLCRQMVMVV HSCHSMGVMH
201: RDLKPENFLF LSKDENSPLK ATDFGLSVFF KPGDKFKDLV GSAYYVAPEV LKRNYGPEAD IWSAGVILYI LLSGVPPFWG ENETGIFDAI LQGQLDFSAD
301: PWPALSDGAK DLVRKMLKYD PKDRLTAAEV LNHPWIREDG EASDKPLDNA VLSRMKQFRA MNKLKKMALK VIAENLSEEE IIGLKEMFKS LDTDNNGIVT
401: LEELRTGLPK LGSKISEAEI RQLMEAADMD GDGSIDYLEF ISATMHMNRI EREDHLYTAF QFFDNDNSGY ITMEELELAM KKYNMGDDKS IKEIIAEVDT
501: DRDGKINYEE FVAMMKKGNP ELVPNRRRM
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)