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AT4G14880.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
cytosol 1.000
ASURE: cytosol
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:27122571 (2016): mitochondrion
  • PMID:26781341 (2016): plasma membrane
  • PMID:26572690 (2016): extracellular region plant-type cell wall
  • PMID:25900983 (2015): plant-type vacuole plant-type vacuole membrane
  • PMID:25900983 (2015): Golgi Golgi apparatus Golgi membrane
  • PMID:25900983 (2015): Golgi trans-Golgi network
  • PMID:25900983 (2015): Golgi trans-Golgi network early endosome
  • PMID:25900983 (2015): Golgi trans-Golgi network multivesicular body
  • PMID:25641898 (2015): plasma membrane
  • PMID:24361574 (2014): plastid plastid stroma
  • PMID:22215637 (2012): plasma membrane
  • PMID:21166475 (2011): cytosol
  • PMID:20423899 (2010): plastid
  • PMID:20061580 (2010): plastid plastid stroma
  • PMID:19329564 (2009): peroxisome
  • PMID:18431481 (2008): plastid
  • PMID:17951448 (2007): peroxisome
  • PMID:17644812 (2007): plasma membrane
  • PMID:17151019 (2007): plant-type vacuole
  • PMID:15574830 (2004): plasma membrane
  • PMID:14617066 (2003): nucleus
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : O-acetylserine (thiol) lyase (OAS-TL) isoform A1
Curator
Summary (TAIR10)
Encodes a cytosolic isoform of cytosolic O-acetylserine(thiol)lyase, a key enzyme in cysteine biosynthesis and for the fixation of inorganic sulfide. It catalyzes the formation of cysteine from O-acetylserine and inorganic sulfide. Gene expression is predominant in the root cortex and the xylem parenchyma. Gene expression is induced in leave, stems and roots by high salt and heavy metal stresses, mediated by ABA. Lines carrying semi-dominant mutations exhibit early senescence.
Computational
Description (TAIR10)
O-acetylserine (thiol) lyase (OAS-TL) isoform A1 (OASA1); FUNCTIONS IN: protein binding, cysteine synthase activity; INVOLVED IN: in 6 processes; LOCATED IN: in 7 components; EXPRESSED IN: 30 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site (InterPro:IPR001216), Cysteine synthase A (InterPro:IPR005859), Pyridoxal phosphate-dependent enzyme, beta subunit (InterPro:IPR001926), Cysteine synthase K/M (InterPro:IPR005856); BEST Arabidopsis thaliana protein match is: O-acetylserine (thiol) lyase (OAS-TL) isoform A2 (TAIR:AT3G22460.1); Has 20496 Blast hits to 20479 proteins in 2663 species: Archae - 403; Bacteria - 14284; Metazoa - 350; Fungi - 659; Plants - 549; Viruses - 2; Other Eukaryotes - 4249 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:GQT-1813-MONOMERBioCyc:ARA:GQT-1814-MONOMERBioCyc:ARA:GQT-1815-MONOMERBioCyc:MetaCyc:AT4G14880-MONOMERBioGrid:12442BRENDA:2.5.1.47EC:2.5.1.47
eggNOG:COG0031eggNOG:KOG1252EMBL:AJ272027EMBL:AL161540EMBL:AY045825EMBL:BT025878EMBL:CP002687
EMBL:X80376EMBL:X84097EMBL:Z97337EnsemblPlants:AT4G14880EnsemblPlants:AT4G14880.1EnsemblPlants:AT4G14880.2EnsemblPlants:AT4G14880.3
EnsemblPlants:AT4G14880.4entrez:827145EvolutionaryTrace:P47998GeneID:827145Genevisible:P47998GO:GO:0004124GO:GO:0005634
GO:GO:0005774GO:GO:0005777GO:GO:0005829GO:GO:0005886GO:GO:0006535GO:GO:0007568GO:GO:0009507
GO:GO:0009567GO:GO:0009570GO:GO:0009860GO:GO:0016020GO:GO:0016740GO:GO:0019344GO:GO:0030170
GO:GO:0046686GO:GO:0048046Gramene:AT4G14880.1Gramene:AT4G14880.2Gramene:AT4G14880.3Gramene:AT4G14880.4hmmpanther:PTHR10314
hmmpanther:PTHR10314:SF101InParanoid:P47998IntAct:P47998InterPro:IPR001216InterPro:IPR001926InterPro:IPR005856InterPro:IPR005859
iPTMnet:P47998KEGG:00270+2.5.1.47KEGG:00920+2.5.1.47KEGG:ath:AT4G14880KO:K01738MINT:MINT-8061212OMA:MGGANER
PaxDb:P47998PDB:1Z7WPDB:1Z7YPDB:2ISQPDBsum:1Z7WPDBsum:1Z7YPDBsum:2ISQ
Pfam:P47998Pfam:PF00291PhylomeDB:P47998PIR:A71412PIR:S48694PRIDE:P47998PRO:PR:P47998
PROSITE:PS00901ProteinModelPortal:P47998Proteomes:UP000006548RefSeq:NP_001190732.1RefSeq:NP_001190733.1RefSeq:NP_193224.1RefSeq:NP_849386.1
SABIO-RK:P47998scanprosite:PS00901SMR:P47998STRING:3702.AT4G14880.1SUPFAM:SSF53686TAIR:AT4G14880tair10-symbols:CYTACS1
tair10-symbols:OASA1tair10-symbols:OLD3TIGRfam:TIGR01136TIGRfam:TIGR01139TIGRFAMs:TIGR01136TIGRFAMs:TIGR01139UniGene:At.30
UniGene:At.34389UniPathway:UPA00136UniProt:P47998
Coordinates (TAIR10) chr4:-:8518209..8520050
Molecular Weight (calculated) 33807.10 Da
IEP (calculated) 5.95
GRAVY (calculated) 0.09
Length 322 amino acids
Sequence (TAIR10)
(BLAST)
001: MASRIAKDVT ELIGNTPLVY LNNVAEGCVG RVAAKLEMME PCSSVKDRIG FSMISDAEKK GLIKPGESVL IEPTSGNTGV GLAFTAAAKG YKLIITMPAS
101: MSTERRIILL AFGVELVLTD PAKGMKGAIA KAEEILAKTP NGYMLQQFEN PANPKIHYET TGPEIWKGTG GKIDGFVSGI GTGGTITGAG KYLKEQNANV
201: KLYGVEPVES AILSGGKPGP HKIQGIGAGF IPSVLNVDLI DEVVQVSSDE SIDMARQLAL KEGLLVGISS GAAAAAAIKL AQRPENAGKL FVAIFPSFGE
301: RYLSTVLFDA TRKEAEAMTF EA
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)