suba logo
AT3G60190.1
Subcellular Consensus
(Prediction and Experimental)

min: heatmap :max

.
SUBAcon:
cytosol 0.961
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:26781341 (2016): plasma membrane
  • PMID:25900983 (2015): plant-type vacuole plant-type vacuole membrane
  • PMID:25900983 (2015): Golgi
  • PMID:25900983 (2015): Golgi Golgi apparatus Golgi membrane
  • PMID:25900983 (2015): Golgi trans-Golgi network
  • PMID:25900983 (2015): Golgi trans-Golgi network early endosome
  • PMID:25900983 (2015): Golgi trans-Golgi network multivesicular body
  • PMID:24134884 (2013): cytoskeleton microtubules
  • PMID:23903016 (2013): plant-type vacuole plant-type vacuole membrane
  • PMID:23396599 (2013): nucleus nuclear envelope nuclear inner membrane
  • PMID:22923678 (2012): plasma membrane
  • PMID:22215637 (2012): plasma membrane
  • PMID:21433285 (2011): plasma membrane
  • PMID:19334764 (2009): plasma membrane
  • PMID:17317660 (2007): plasma membrane
  • PMID:17151019 (2007): plant-type vacuole
  • PMID:16618929 (2006): plasma membrane
  • PMID:15539469 (2004): plant-type vacuole
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : DYNAMIN-like 1E
Curator
Summary (TAIR10)
At3g60190 encodes Arabidopsis dynamin-related protein 1E, DRP1E, also known as EDR3, ADL4 and ADL1E, which is 624 amino acid residues long, has a predicted mass of 69.8 kDa and a pI of 7.5. Dynamin-related protein 1E belongs to a plant-specific subclass of dynamin-related proteins (DRP1), consisting of five members in Arabidopsis (A, B, C, D, E). This class is characterized by having an N-terminal GTPase domain, a central ‘dynamin 2‘ domain and a C-terminal GTPase effector domain (GED), a typical structure for plant dynamin-related proteins. However, this class lacks a PH domain and a proline-rich domain, which are found in classical animal dynamin-like proteins. Based on work on animal dynamins, the plant DRP1 proteins should be able to form polymeric structures that wrap around membranes to facilitate membrane tubulation and pinching off of vesicles, processes that are essential to vesicle trafficking and membrane compartmentalization. The edr3 mutation causes a P77L substitution in the G2 motif of the GTPase domain of DRP1E. edr3 mutant Arabidopsis plants display enhanced cell death in response to powdery mildew infection.
Computational
Description (TAIR10)
DYNAMIN-like 1E (DL1E); FUNCTIONS IN: GTP binding, GTPase activity; INVOLVED IN: response to cadmium ion, vesicle-mediated transport, defense response to fungus; LOCATED IN: mitochondrion, plasma membrane, vacuole; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Dynamin GTPase effector (InterPro:IPR003130), Dynamin, GTPase domain (InterPro:IPR001401), Dynamin, GTPase region, conserved site (InterPro:IPR019762), GTPase effector domain, GED (InterPro:IPR020850), Dynamin central region (InterPro:IPR000375); BEST Arabidopsis thaliana protein match is: DYNAMIN-like 1D (TAIR:AT2G44590.3); Has 2915 Blast hits to 2753 proteins in 324 species: Archae - 2; Bacteria - 53; Metazoa - 1058; Fungi - 869; Plants - 577; Viruses - 0; Other Eukaryotes - 356 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT3G60190-MONOMERBioGrid:10503eggNOG:COG0699eggNOG:KOG0446EMBL:AF180733EMBL:AF428332EMBL:AF488725
EMBL:AJ304842EMBL:AL138658EMBL:CP002686EnsemblPlants:AT3G60190EnsemblPlants:AT3G60190.1entrez:825189Gene3D:3.40.50.300
GeneID:825189Genevisible:Q9FNX5GO:GO:0003924GO:GO:0005525GO:GO:0005739GO:GO:0005773GO:GO:0005774
GO:GO:0005874GO:GO:0005886GO:GO:0007049GO:GO:0009506GO:GO:0009524GO:GO:0016192GO:GO:0046686
GO:GO:0050832GO:GO:0051301Gramene:AT3G60190.1hmmpanther:PTHR11566hmmpanther:PTHR11566:SF80HOGENOM:HOG000161068InParanoid:Q9FNX5
IntAct:Q9FNX5InterPro:IPR000375InterPro:IPR001401InterPro:IPR003130InterPro:IPR019762InterPro:IPR020850InterPro:IPR022812
InterPro:IPR027417InterPro:IPR030381iPTMnet:Q9FNX5KEGG:ath:AT3G60190ncoils:CoilOMA:ADINKNTPANTHER:PTHR11566
PaxDb:Q9FNX5Pfam:PF00350Pfam:PF01031Pfam:PF02212Pfam:Q9FNX5Pfscan:PS51388Pfscan:PS51718
PhylomeDB:Q9FNX5PIR:T47843PRIDE:Q9FNX5PRINTS:PR00195PRO:PR:Q9FNX5PROSITE:PS00410PROSITE:PS51388
PROSITE:PS51718ProteinModelPortal:Q9FNX5Proteomes:UP000006548RefSeq:NP_567094.1scanprosite:PS00410SMART:SM00053SMART:SM00302
SMR:Q9FNX5STRING:3702.AT3G60190.1SUPFAM:SSF52540TAIR:AT3G60190tair10-symbols:ADL1Etair10-symbols:ADL4tair10-symbols:ADLP2
tair10-symbols:DL1Etair10-symbols:DRP1Etair10-symbols:EDR3UniGene:At.20951UniProt:Q9FNX5
Coordinates (TAIR10) chr3:-:22244367..22247651
Molecular Weight (calculated) 69807.80 Da
IEP (calculated) 7.59
GRAVY (calculated) -0.33
Length 624 amino acids
Sequence (TAIR10)
(BLAST)
001: MTTMESLIGL VNRIQRACTV LGDYGGGTGS NAFNSLWEAL PTVAVVGGQS SGKSSVLESI VGRDFLPRGS GIVTRRPLVL QLHKTDDGTE EYAEFLHLPK
101: KQFTDFALVR REIQDETDRI TGKNKQISPV PIHLSIYSPN VVNLTLIDLP GLTKVAVEGQ PETIAEDIES MVRTYVDKPN CIILAISPAN QDIATSDAIK
201: LAKDVDPTGE RTFGVLTKLD LMDKGTNALE VLEGRSYRLQ HPWVGIVNRS QADINKNVDM MLARRKEREY FDTSPDYGHL ASKMGSEYLA KLLSKHLESV
301: IRTRIPSILS LINKSIEELE RELDRMGRPV AVDAGAQLYT ILEMCRAFDK IFKEHLDGGR PGGDRIYGVF DNQLPAALKK LPFDRHLSLQ SVKKIVSEAD
401: GYQPHLIAPE QGYRRLIEGA LGYFRGPAEA SVDAVHYVLK ELVRKSISET EELKRFPSLQ VELAAAANSS LEKFREESKK SVIRLVDMES AYLTAEFFRK
501: LPQEIERPVT NSKNQTASPS SATLDQYGDG HFRRIASNVS AYVNMVSDTL RNTIPKACVY CQVRQAKLAL LNYFYSQISK REGKQLGQLL DEDPALMDRR
601: LECAKRLELY KKARDEIDAV AWVR
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)