AT3G55360.1
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Subcellular Consensus
(Prediction and Experimental) min:  :max.
SUBAcon:endoplasmic reticulum 0.500 plasma membrane 0.500 ASURE: endoplasmic reticulum,plasma membrane What is SUBAcon? |
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| Experimental Localisations and PPI |
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SUBAcon links
AGI-AGI relationships |
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| Description (TAIR10) | protein_coding : 3-oxo-5-alpha-steroid 4-dehydrogenase family protein | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Curator Summary (TAIR10) |
Enoyl-CoA reductase is involved in all very long chain fatty acids (VLCFA) elongation reactions that are required for cuticular wax, storage lipid and sphingolipid metabolism. The protein is located in the ER, but in contrast to its yeast homolog TSC13 is not particularly enriched in the nuclear envelope-vacuole junction. Mutants in this gene show abnormal organ morphology and stem glossiness. Cells in all tissues are only about 1/3 of the size of wild type cells. The morphological changes are most likely to result from the reduction in the VLCFA content of sphingolipids. Mutants also show abnormalities in the endocytic membrane organization and transport. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Computational Description (TAIR10) |
ECERIFERUM 10 (CER10); FUNCTIONS IN: fatty acid elongase activity, trans-2-enoyl-CoA reductase (NADPH) activity, 3-oxo-5-alpha-steroid 4-dehydrogenase activity; INVOLVED IN: sphingolipid metabolic process, wax biosynthetic process; LOCATED IN: endoplasmic reticulum, fatty acid elongase complex, plasma membrane, endoplasmic reticulum membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal (InterPro:IPR001104); BEST Arabidopsis thaliana protein match is: 3-oxo-5-alpha-steroid 4-dehydrogenase family protein (TAIR:AT5G16010.1); Has 1087 Blast hits to 1087 proteins in 269 species: Archae - 0; Bacteria - 73; Metazoa - 353; Fungi - 144; Plants - 184; Viruses - 0; Other Eukaryotes - 333 (source: NCBI BLink). | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Annotations |
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| Coordinates (TAIR10) | chr3:-:20521186..20522856 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Molecular Weight (calculated) | 35725.50 Da | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| IEP (calculated) | 9.75 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| GRAVY (calculated) | 0.02 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Length | 310 amino acids | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sequence (TAIR10) (BLAST) |
001: MKVTVVSRSG REVLKAPLDL PDSATVADLQ EAFHKRAKKF YPSRQRLTLP VTPGSKDKPV VLNSKKSLKE YCDGNNNSLT VVFKDLGAQV SYRTLFFFEY 101: LGPLLIYPVF YYFPVYKFLG YGEDCVIHPV QTYAMYYWCF HYFKRILETF FVHRFSHATS PIGNVFRNCA YYWSFGAYIA YYVNHPLYTP VSDLQMKIGF 201: GFGLVCQVAN FYCHILLKNL RDPSGAGGYQ IPRGFLFNIV TCANYTTEIY QWLGFNIATQ TIAGYVFLAV AALIMTNWAL GKHSRLRKIF DGKDGKPKYP 301: RRWVILPPFL |
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| See Also |
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Citation
If you find this resource useful please cite one of the following publications:
Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)
Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)