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AT3G50630.1
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
nucleus 1.000
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : KIP-related protein 2
Curator
Summary (TAIR10)
Kip-related protein (KRP) gene, encodes CDK (cyclin-dependent kinase) inhibitor (CKI), negative regulator of cell division. A member of seven KRP genes found in Arabidopsis thaliana. Differential expression patterns for distinct KRPs were revealed by in situ hybridization. Gene was isolated from a yeast two hybrid screen as an interacting protein of CDC2A. Recombinant protein has a strong kinase inhibitor activity in vitro. Transcript is expressed in all tissues examined but is differentially distributed from ICK1. Controls the onset of the endoreduplication cycle through inhibition of CDKA;1. The KRP2 protein abundance is regulated by proteolysis through CDKB1;1 phosphorylation.
Computational
Description (TAIR10)
KIP-related protein 2 (KRP2); FUNCTIONS IN: protein binding, kinase inhibitor activity, cyclin-dependent protein kinase inhibitor activity; INVOLVED IN: negative regulation of cyclin-dependent protein kinase activity, DNA endoreduplication; LOCATED IN: nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 9 growth stages; CONTAINS InterPro DOMAIN/s: Cyclin-dependent kinase inhibitor (InterPro:IPR003175), Cyclin-dependent kinase inhibitor, plant (InterPro:IPR016701); Has 103 Blast hits to 103 proteins in 17 species: Archae - 0; Bacteria - 0; Metazoa - 2; Fungi - 2; Plants - 97; Viruses - 0; Other Eukaryotes - 2 (source: NCBI BLink).
Protein Annotations
BioGrid:9544eggNOG:ENOG410JX2ReggNOG:ENOG41104CMEMBL:AJ251851
EMBL:AK176528EMBL:AK176728EMBL:AL132979EMBL:AY088290
EMBL:BT028944EMBL:CP002686EnsemblPlants:AT3G50630EnsemblPlants:AT3G50630.1
entrez:824226GeneID:824226Genevisible:Q9SCR2GO:GO:0004861
GO:GO:0005654GO:GO:0007050GO:GO:0019210GO:GO:0042023
GO:GO:0045736Gramene:AT3G50630.1hmmpanther:PTHR10265hmmpanther:PTHR10265:SF24
HOGENOM:HOG000239712InParanoid:Q9SCR2IntAct:Q9SCR2InterPro:IPR003175
InterPro:IPR016701KEGG:ath:AT3G50630OMA:SPCVQATPANTHER:PTHR10265
PaxDb:Q9SCR2Pfam:PF02234Pfam:Q9SCR2PhylomeDB:Q9SCR2
PIR:T46140PIRSF:PIRSF017811PRIDE:Q9SCR2PRO:PR:Q9SCR2
ProteinModelPortal:Q9SCR2Proteomes:UP000006548RefSeq:NP_190632.1SMR:Q9SCR2
STRING:3702.AT3G50630.1TAIR:AT3G50630tair10-symbols:ICK2tair10-symbols:KRP2
UniGene:At.838UniProt:Q9SCR2
Coordinates (TAIR10) chr3:+:18800508..18801366
Molecular Weight (calculated) 24037.90 Da
IEP (calculated) 4.43
GRAVY (calculated) -0.88
Length 209 amino acids
Sequence (TAIR10)
(BLAST)
001: MAAVRRRERD VVEENGVTTT TVKRRKMEEE VDLVESRIIL SPCVQATNRG GIVARNSAGA SETSVVIVRR RDSPPVEEQC QIEEEDSSVS CCSTSEEKSK
101: RRIEFVDLEE NNGDDRETET SWIYDDLNKS EESMNMDSSS VAVEDVESRR RLRKSLHETV KEAELEDFFQ VAEKDLRNKL LECSMKYNFD FEKDEPLGGG
201: RYEWVKLNP
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)