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AT3G48750.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
cytosol 1.000
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:26781341 (2016): plasma membrane
  • PMID:25900983 (2015): Golgi trans-Golgi network multivesicular body
  • PMID:18433157 (2008): cytosol
  • PMID:18433157 (2008): nucleus
  • PMID:17317660 (2007): plasma membrane
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : cell division control 2
Curator
Summary (TAIR10)
A-type cyclin-dependent kinase. Together with its specific inhibitor, the Kip-related protein, KRP2 they regulate the mitosis-to-endocycle transition during leaf development. Dominant negative mutations abolish cell division. Loss of function phenotype has reduced fertility with failure to transmit via pollen. Pollen development is arrested at the second mitotic division. Expression is regulated by environmental and chemical signals. Part of the promoter is responsible for expression in trichomes. Functions as a positive regulator of cell proliferation during development of the male gametophyte, embryo and endosperm. Phosphorylation of threonine 161 is required for activation of its associated kinase.
Computational
Description (TAIR10)
cell division control 2 (CDC2); FUNCTIONS IN: protein binding, protein kinase activity, cyclin-dependent protein kinase activity, kinase activity; INVOLVED IN: in 8 processes; LOCATED IN: in 6 components; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: cyclin-dependent kinase B1;2 (TAIR:AT2G38620.2); Has 126125 Blast hits to 124135 proteins in 4221 species: Archae - 112; Bacteria - 14002; Metazoa - 46757; Fungi - 13170; Plants - 30525; Viruses - 484; Other Eukaryotes - 21075 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT3G48750-MONOMERBioGrid:9354BRENDA:2.7.11.22EC:2.7.11.22EC:2.7.11.23eggNOG:ENOG410XPP3eggNOG:KOG0594
EMBL:AK226373EMBL:AL132963EMBL:AY085153EMBL:AY090353EMBL:BT024706EMBL:CP002686EMBL:D10850
EMBL:M59198EMBL:S45387EMBL:X57839EnsemblPlants:AT3G48750EnsemblPlants:AT3G48750.1entrez:824036GeneID:824036
Genevisible:P24100GO:GO:0000911GO:GO:0004672GO:GO:0004693GO:GO:0005524GO:GO:0005634GO:GO:0005737
GO:GO:0005829GO:GO:0005886GO:GO:0007067GO:GO:0008284GO:GO:0008353GO:GO:0008356GO:GO:0009409
GO:GO:0009555GO:GO:0009574GO:GO:0009793GO:GO:0010005GO:GO:0016301GO:GO:0040020GO:GO:0042023
GO:GO:0048229Gramene:AT3G48750.1hmmpanther:PTHR24056hmmpanther:PTHR24056:SF230HOGENOM:HOG000233024InParanoid:P24100IntAct:P24100
InterPro:IPR000719InterPro:IPR008271InterPro:IPR011009InterPro:IPR017441iPTMnet:P24100KEGG:ath:AT3G48750KO:K02206
OMA:LPDYISTPaxDb:P24100Pfam:P24100Pfam:PF00069Pfscan:PS50011PhylomeDB:P24100PIR:S23095
PIR:T49271PRIDE:P24100PRO:PR:P24100PROSITE:PS00107PROSITE:PS00108PROSITE:PS50011ProteinModelPortal:P24100
Proteomes:UP000006548Reactome:R-ATH-110056Reactome:R-ATH-113510Reactome:R-ATH-1538133Reactome:R-ATH-174184Reactome:R-ATH-68911Reactome:R-ATH-68949
Reactome:R-ATH-68962Reactome:R-ATH-69017Reactome:R-ATH-69205Reactome:R-ATH-69273Reactome:R-ATH-69656RefSeq:NP_566911.1scanprosite:PS00107
scanprosite:PS00108SMART:SM00220SMR:P24100STRING:3702.AT3G48750.1SUPFAM:SSF56112TAIR:AT3G48750tair10-symbols:CDC2
tair10-symbols:CDC2Atair10-symbols:CDC2AATtair10-symbols:CDK2tair10-symbols:CDKA1tair10-symbols:CDKA;1UniGene:At.24166UniProt:P24100
Coordinates (TAIR10) chr3:+:18072238..18074296
Molecular Weight (calculated) 34032.20 Da
IEP (calculated) 6.92
GRAVY (calculated) -0.34
Length 294 amino acids
Sequence (TAIR10)
(BLAST)
001: MDQYEKVEKI GEGTYGVVYK ARDKVTNETI ALKKIRLEQE DEGVPSTAIR EISLLKEMQH SNIVKLQDVV HSEKRLYLVF EYLDLDLKKH MDSTPDFSKD
101: LHMIKTYLYQ ILRGIAYCHS HRVLHRDLKP QNLLIDRRTN SLKLADFGLA RAFGIPVRTF THEVVTLWYR APEILLGSHH YSTPVDIWSV GCIFAEMISQ
201: KPLFPGDSEI DQLFKIFRIM GTPYEDTWRG VTSLPDYKSA FPKWKPTDLE TFVPNLDPDG VDLLSKMLLM DPTKRINARA ALEHEYFKDL GGMP
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)