suba logo
AT3G44200.1
Subcellular Consensus
(Prediction and Experimental)

min: heatmap :max

.
SUBAcon:
cytosol 1.000
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:28505371 (2017): cytoskeleton microtubules
  • PMID:21605211 (2011): cytoskeleton
  • PMID:18266916 (2008): cytoskeleton microtubules
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : NIMA (never in mitosis, gene A)-related 6
Curator
Summary (TAIR10)
Encodes AtNek5, a member of the NIMA-related serine/threonine kinases (Neks) that have been linked to cell-cycle regulation in fungi and mammals. Plant Neks might be involved in plant development processes.Interacts physically with plant kinesins ARK1 and ARK2. Mutants show defects in root epidermal cell morphology, trichome branching and other epidermal cell abnormalities suggesting a rol e in epidermal cell differentiation. NEK6 co-localizes with cortical microtubules.
Computational
Description (TAIR10)
NIMA (never in mitosis, gene A)-related 6 (NEK6); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: microtubule-based process, epidermal cell differentiation; LOCATED IN: cortical microtubule; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: NIMA-related serine/threonine kinase 1 (TAIR:AT1G54510.3); Has 127749 Blast hits to 124714 proteins in 4408 species: Archae - 106; Bacteria - 14910; Metazoa - 47444; Fungi - 12949; Plants - 30417; Viruses - 519; Other Eukaryotes - 21404 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT3G44200-MONOMERBioGrid:8862EC:2.7.11.1eggNOG:ENOG410Y7JFeggNOG:KOG0589EMBL:AB290931EMBL:AK229091
EMBL:AL353814EMBL:CP002686EnsemblPlants:AT3G44200EnsemblPlants:AT3G44200.1entrez:823542GeneID:823542Genevisible:Q0WPH8
GO:GO:0004672GO:GO:0004674GO:GO:0005524GO:GO:0007017GO:GO:0009913GO:GO:0043622GO:GO:0055028
Gramene:AT3G44200.1hmmpanther:PTHR24362hmmpanther:PTHR24362:SF258HOGENOM:HOG000238503InParanoid:Q0WPH8IntAct:Q0WPH8InterPro:IPR000719
InterPro:IPR008271InterPro:IPR011009InterPro:IPR017441iPTMnet:Q0WPH8KEGG:ath:AT3G44200KO:K08857OMA:DISSEMM
PaxDb:Q0WPH8Pfam:PF00069Pfam:Q0WPH8Pfscan:PS50011PhylomeDB:Q0WPH8PIR:T49136PRIDE:Q0WPH8
PRO:PR:Q0WPH8PROSITE:PS00107PROSITE:PS00108PROSITE:PS50011ProteinModelPortal:Q0WPH8Proteomes:UP000006548Reactome:R-ATH-179409
RefSeq:NP_190006.2scanprosite:PS00107scanprosite:PS00108SMART:SM00220SMR:Q0WPH8STRING:3702.AT3G44200.1SUPFAM:SSF56112
TAIR:AT3G44200tair10-symbols:ATNEK6tair10-symbols:IBO1tair10-symbols:NEK6UniGene:At.46652UniProt:Q0WPH8
Coordinates (TAIR10) chr3:+:15906788..15911365
Molecular Weight (calculated) 106395.00 Da
IEP (calculated) 7.21
GRAVY (calculated) -0.71
Length 956 amino acids
Sequence (TAIR10)
(BLAST)
001: MESRMDQYEL MEQIGRGAFG AAILVHHKAE RKKYVLKKIR LARQTERCRR SAHQEMSLIA RVQHPYIVEF KEAWVEKGCY VCIVTGYCEG GDMAELMKKS
101: NGVYFPEEKL CKWFTQLLLA VEYLHSNYVL HRDLKCSNIF LTKDQDVRLG DFGLAKTLKA DDLTSSVVGT PNYMCPELLA DIPYGFKSDI WSLGCCIYEM
201: AAYRPAFKAF DMAGLISKVN RSSIGPLPPC YSPSLKALIK GMLRKNPEYR PNASEILKHP YLQPYVEQYR PTLSAASITP EKPLNSREGR RSMAESQNSN
301: SSSEKDNFYV SDKNIRYVVP SNGNKVTETD SGFVDDEDIL DHVQQSAENG NLQSVSATKP DGHGILKPVH SDQRPDVIQP RHPKTIRNIM MVLKEEKARE
401: NGSPMRSNRS RPSSVPTQKN NVETPSKIPK LGDIAHSSKT NASTPIPPSK LASDSARTPG SFPPKHHMPV IDSSPKLKPR NDRISPSPAA KHEAEEAMSV
501: KRRQRTPPTL PRRTSLIAHQ SRQLGADISN MAAKETAKLH PSVPSESETN SHQSRVHASP VSTTPEPKRT SVGSAKGMQS ESSNSISSSL SMQAFELCDD
601: ASTPYIDMTE HTTPDDHRRS CHSEYSYSFP DISSEMMIRR DEHSTSMRLT EIPDSVSGVQ NTIAHHQPER EQGSCPTVLK DDSPATLQSY EPNTSQHQHG
701: DDKFTVKEFV SSVPGPAPLP LHVEPSHQVN SHSDNKTSVM SQNSALEKNN SHSHPHPVVD DVIHVIRHSS FRVGSDQPVM ESVEVGVQNV DMGKLINVVR
801: DEMEVRKGAT PSESPTTRSI ISEPDSRTEP RPKEPDPITN YSETKSFNSC SDSSPAETRT NSFVPEEETT PTPPVKETLD IKSFRQRAEA LEGLLELSAD
901: LLEQSRLEEL AIVLQPFGKN KVSPRETAIW LAKSLKGMMI EDINNNNSSG SSRNCS
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)