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AT3G22590.1
Subcellular Consensus
(Prediction and Experimental)

min: heatmap :max

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SUBAcon:
cytosol 0.999
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : PLANT HOMOLOGOUS TO PARAFIBROMIN
Curator
Summary (TAIR10)
Encodes PLANT HOMOLOGOUS TO PARAFIBROMIN (PHP), a homolog of human Paf1 Complex (Paf1C) subunit Parafibromin. Human Parafibromin assists in mediating output from the Wnt signaling pathway, and dysfunction of the encoding gene HRPT2 conditions specific cancer-related disease phenotypes. PHP resides in a ~670-kDa protein complex in nuclear extracts, and physically interacts with other known Paf1C-related proteins in vivo. Loss of PHP specifically conditioned accelerated phase transition from vegetative growth to flowering and resulted in misregulation of a very limited subset of genes that included the flowering repressor FLOWERING LOCUS C (FLC).
Computational
Description (TAIR10)
PLANT HOMOLOGOUS TO PARAFIBROMIN (PHP); CONTAINS InterPro DOMAIN/s: RNA polymerase II accessory factor, Cdc73 (InterPro:IPR007852); Has 502 Blast hits to 395 proteins in 198 species: Archae - 0; Bacteria - 0; Metazoa - 257; Fungi - 127; Plants - 42; Viruses - 0; Other Eukaryotes - 76 (source: NCBI BLink).
Protein Annotations
eggNOG:COG5157eggNOG:KOG3786EMBL:AP000731EMBL:AY065437EMBL:AY142611EMBL:CP002686EnsemblPlants:AT3G22590
EnsemblPlants:AT3G22590.1entrez:821831GeneID:821831Genevisible:Q9LJ87GO:GO:0005634GO:GO:0006355GO:GO:0006368
GO:GO:0009908GO:GO:0009911GO:GO:0010228GO:GO:0016593GO:GO:0051568Gramene:AT3G22590.1hmmpanther:PTHR12466
hmmpanther:PTHR12466:SF8HOGENOM:HOG000265304InterPro:IPR007852InterPro:IPR031336InterPro:IPR032041KEGG:ath:AT3G22590KO:K15175
OMA:KPDDWDRPANTHER:PTHR12466PaxDb:Q9LJ87Pfam:PF05179Pfam:PF16050Pfam:Q9LJ87PhylomeDB:Q9LJ87
PRO:PR:Q9LJ87ProteinModelPortal:Q9LJ87Proteomes:UP000006548RefSeq:NP_188898.1SMR:Q9LJ87STRING:3702.AT3G22590.1TAIR:AT3G22590
tair10-symbols:CDC73tair10-symbols:PHPUniGene:At.28485UniProt:Q9LJ87
Coordinates (TAIR10) chr3:+:8003999..8005452
Molecular Weight (calculated) 47546.30 Da
IEP (calculated) 7.62
GRAVY (calculated) -0.63
Length 415 amino acids
Sequence (TAIR10)
(BLAST)
001: MDPLSVLKEF TIRGDIDKIE RVGANYRFGS EYSFPCATET AYRSKSGSLY TLEALVHYVK NQQLKHGEYM QSTVKNSVPA VTLPDRKPLL DYLTGRVASS
101: DSIDFLLLQQ QNAQSQKQNE EYRPDQDNSA FVSRENAIAD MEVEDFGKSG EDVDYIMLIR SNERPLKSRD AILQCKNRDF YSVLVNSTKR EEERQRIESH
201: QRKDGLVAKS RLMGAEERGI VGFSSGGGDD NGYDANPKSK LHFKAGKIGE GVPIILVPSA FQTLITIYNV KEFLEDGVYI PNDVKAKEMK GLKPDCITVQ
301: KKFSRDRERV VTAYEVRDKP SALKPDDWDR VVAVFVLGKD WQFKDWPFKD HVEIFNKIIG FFLRFEDDSI ESAKTVKQWN VKIISISKNK RHQDRAAALE
401: VWEKLEEFVR SRSHS
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)