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AT3G21640.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
plasma membrane 1.000
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : FKBP-type peptidyl-prolyl cis-trans isomerase family protein
Curator
Summary (TAIR10)
encodes a 42 kDa FK506-binding protein (AtFKBP42) that possesses similarity to multidomain peptidyl-prolyl cis/trans isomerases (PPIases, EC 5.2.1.8), which are known to be components of mammalian steroid hormone receptor complexes. The protein appears to be localized to the plasma membrane by electron microscopy and binds to HSP90.1 and calmodulin in vitro. It also aggregates citrate synthase in vitro but does NOT show PPIase activity in vivo. Mutants are reduced in size and exhibit disoriented growth in all organs.
Computational
Description (TAIR10)
TWISTED DWARF 1 (TWD1); CONTAINS InterPro DOMAIN/s: Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide TPR2 (InterPro:IPR013105), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734), Peptidyl-prolyl cis-trans isomerase, FKBP-type (InterPro:IPR001179); BEST Arabidopsis thaliana protein match is: rotamase FKBP 1 (TAIR:AT3G25230.2); Has 6043 Blast hits to 5631 proteins in 871 species: Archae - 12; Bacteria - 1331; Metazoa - 2461; Fungi - 414; Plants - 774; Viruses - 0; Other Eukaryotes - 1051 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT3G21640-MONOMERBioGrid:7050EC:5.2.1.8eggNOG:COG0545eggNOG:KOG0543EMBL:AB019232EMBL:AJ224640
EMBL:AY093009EMBL:BT001192EMBL:CP002686EnsemblPlants:AT3G21640EnsemblPlants:AT3G21640.1entrez:821718EvolutionaryTrace:Q9LDC0
Gene3D:1.10.150.160Gene3D:1.25.40.10GeneID:821718Genevisible:Q9LDC0GO:GO:0000413GO:GO:0003755GO:GO:0005516
GO:GO:0005528GO:GO:0005774GO:GO:0005789GO:GO:0005886GO:GO:0009734GO:GO:0016021GO:GO:0048366
GO:GO:0061077Gramene:AT3G21640.1hmmpanther:PTHR10516hmmpanther:PTHR10516:SF145HOGENOM:HOG000006189InParanoid:Q9LDC0IntAct:Q9LDC0
InterPro:IPR001179InterPro:IPR011990InterPro:IPR013026InterPro:IPR019734InterPro:IPR023114InterPro:IPR023566KEGG:ath:AT3G21640
ncoils:CoilOMA:MDGNALFPANTHER:PTHR10516PaxDb:Q9LDC0PDB:2F4EPDB:2IF4PDBsum:2F4E
PDBsum:2IF4Pfam:PF00254Pfam:PF07719Pfam:PF13181Pfam:PF13414Pfam:Q9LDC0Pfscan:PS50005
Pfscan:PS50059Pfscan:PS50293PhylomeDB:Q9LDC0PRIDE:Q9LDC0PRO:PR:Q9LDC0PROSITE:PS50005PROSITE:PS50059
PROSITE:PS50293ProteinModelPortal:Q9LDC0Proteomes:UP000006548RefSeq:NP_188801.2SMART:SM00028SMR:Q9LDC0STRING:3702.AT3G21640.1
SUPFAM:SSF48452SUPFAM:SSF54534TAIR:AT3G21640tair10-symbols:ATFKBP42tair10-symbols:FKBP42tair10-symbols:TWD1tair10-symbols:UCU2
TCDB:8.A.11.1.1TMHMM:TMhelixUniGene:At.5664UniProt:Q9LDC0
Coordinates (TAIR10) chr3:-:7619025..7621097
Molecular Weight (calculated) 41807.80 Da
IEP (calculated) 6.60
GRAVY (calculated) -0.68
Length 365 amino acids
Sequence (TAIR10)
(BLAST)
001: MDESLEHQTQ THDQESEIVT EGSAVVHSEP SQEGNVPPKV DSEAEVLDEK VSKQIIKEGH GSKPSKYSTC FLHYRAWTKN SQHKFEDTWH EQQPIELVLG
101: KEKKELAGLA IGVASMKSGE RALVHVGWEL AYGKEGNFSF PNVPPMADLL YEVEVIGFDE TKEGKARSDM TVEERIGAAD RRKMDGNSLF KEEKLEEAMQ
201: QYEMAIAYMG DDFMFQLYGK YQDMALAVKN PCHLNIAACL IKLKRYDEAI GHCNIVLTEE EKNPKALFRR GKAKAELGQM DSARDDFRKA QKYAPDDKAI
301: RRELRALAEQ EKALYQKQKE MYKGIFKGKD EGGAKSKSLF WLIVLWQWFV SLFSRIFRRH RVKAD
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)