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AT3G18524.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
nucleus 0.717
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : MUTS homolog 2
Curator
Summary (TAIR10)
Encodes a DNA mismatch repair homolog of human MutS gene, MSH6. MSH2 is involved in maintaining genome stability and repressing recombination of mismatched heteroduplexes.There are four MutS genes in Arabidopsis, MSH2, MSH3, MSH6, and MSH7, which all act as heterodimers and bind to 51-mer duplexes. MSH2 has different binding specificity to different mismatches in combination with MSH3, MSH6, or MSH7.
Computational
Description (TAIR10)
MUTS homolog 2 (MSH2); FUNCTIONS IN: damaged DNA binding, protein binding, mismatched DNA binding, ATP binding; INVOLVED IN: mismatch repair, negative regulation of reciprocal meiotic recombination; LOCATED IN: plasma membrane; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA mismatch repair protein MutS, clamp (InterPro:IPR007861), DNA mismatch repair protein MutS, connector (InterPro:IPR007860), DNA mismatch repair protein MutS, core (InterPro:IPR007696), DNA mismatch repair protein MutS, C-terminal (InterPro:IPR000432), DNA mismatch repair protein MutS-like, N-terminal (InterPro:IPR007695), DNA mismatch repair protein, MSH2 (InterPro:IPR011184); BEST Arabidopsis thaliana protein match is: homolog of DNA mismatch repair protein MSH3 (TAIR:AT4G25540.1); Has 13560 Blast hits to 13453 proteins in 2654 species: Archae - 128; Bacteria - 8942; Metazoa - 734; Fungi - 813; Plants - 457; Viruses - 3; Other Eukaryotes - 2483 (source: NCBI BLink).
Protein Annotations
BioGrid:6716eggNOG:COG0249eggNOG:KOG0219EMBL:AB026658EMBL:AF002706EMBL:AF003005EMBL:AF026549
EMBL:AF109243EMBL:AP001303EMBL:CP002686EMBL:U87911EnsemblPlants:AT3G18524EnsemblPlants:AT3G18524.1entrez:821383
Gene3D:3.40.50.300GeneID:821383Genevisible:O24617GO:GO:0000400GO:GO:0000403GO:GO:0000404GO:GO:0000406
GO:GO:0003684GO:GO:0005524GO:GO:0005886GO:GO:0006290GO:GO:0006298GO:GO:0006301GO:GO:0006311
GO:GO:0030983GO:GO:0032137GO:GO:0032138GO:GO:0032301GO:GO:0032302GO:GO:0043570GO:GO:0045128
Gramene:AT3G18524.1hmmpanther:PTHR11361hmmpanther:PTHR11361:SF35HOGENOM:HOG000196498InParanoid:O24617InterPro:IPR000432InterPro:IPR007695
InterPro:IPR007696InterPro:IPR007860InterPro:IPR007861InterPro:IPR011184InterPro:IPR027417InterPro:IPR032642iPTMnet:O24617
KEGG:ath:AT3G18524KO:K08735MINT:MINT-8060640ncoils:CoilOMA:NDWYLAYPANTHER:PTHR11361:SF35PaxDb:O24617
Pfam:O24617Pfam:PF00488Pfam:PF01624Pfam:PF05188Pfam:PF05190Pfam:PF05192PhylomeDB:O24617
PIRSF:PIRSF005813PRIDE:O24617PRO:PR:O24617PROSITE:PS00486ProteinModelPortal:O24617Proteomes:UP000006548Reactome:R-ATH-5358565
Reactome:R-ATH-5358606RefSeq:NP_566804.3scanprosite:PS00486SMART:SM00533SMART:SM00534SMR:O24617STRING:3702.AT3G18524.1
SUPFAM:SSF48334SUPFAM:SSF52540TAIR:AT3G18524tair10-symbols:ATMSH2tair10-symbols:MSH2UniGene:At.10475UniProt:O24617
Coordinates (TAIR10) chr3:-:6368151..6372409
Molecular Weight (calculated) 105509.00 Da
IEP (calculated) 6.02
GRAVY (calculated) -0.30
Length 937 amino acids
Sequence (TAIR10)
(BLAST)
001: MEGNFEEQNK LPELKLDAKQ AQGFLSFYKT LPNDTRAVRF FDRKDYYTAH GENSVFIAKT YYHTTTALRQ LGSGSNALSS VSISRNMFET IARDLLLERN
101: DHTVELYEGS GSNWRLVKTG SPGNIGSFED VLFANNEMQD TPVVVSIFPS FHDGRCVIGM AYVDLTRRVL GLAEFLDDSR FTNLESSLIA LGAKECIFPA
201: ESGKSNECKS LYDSLERCAV MITERKKHEF KGRDLDSDLK RLVKGNIEPV RDLVSGFDLA TPALGALLSF SELLSNEDNY GNFTIRRYDI GGFMRLDSAA
301: MRALNVMESK TDANKNFSLF GLMNRTCTAG MGKRLLHMWL KQPLVDLNEI KTRLDIVQCF VEEAGLRQDL RQHLKRISDV ERLLRSLERR RGGLQHIIKL
401: YQSTIRLPFI KTAMQQYTGE FASLISERYL KKLEALSDQD HLGKFIDLVE CSVDLDQLEN GEYMISSSYD TKLASLKDQK ELLEQQIHEL HKKTAIELDL
501: QVDKALKLDK AAQFGHVFRI TKKEEPKIRK KLTTQFIVLE TRKDGVKFTN TKLKKLGDQY QSVVDDYRSC QKELVDRVVE TVTSFSEVFE DLAGLLSEMD
601: VLLSFADLAA SCPTPYCRPE ITSSDAGDIV LEGSRHPCVE AQDWVNFIPN DCRLMRGKSW FQIVTGPNMG GKSTFIRQVG VIVLMAQVGS FVPCDKASIS
701: IRDCIFARVG AGDCQLRGVS TFMQEMLETA SILKGASDKS LIIIDELGRG TSTYDGFGLA WAICEHLVQV KRAPTLFATH FHELTALAQA NSEVSGNTVG
801: VANFHVSAHI DTESRKLTML YKVEPGACDQ SFGIHVAEFA NFPESVVALA REKAAELEDF SPSSMIINNE ESGKRKSRED DPDEVSRGAE RAHKFLKEFA
901: AIPLDKMELK DSLQRVREMK DELEKDAADC HWLRQFL
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)