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AT3G08730.1
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
cytosol 1.000
ASURE: cytosol
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : protein-serine kinase 1
Curator
Summary (TAIR10)
Encodes a protein-serine kinase that phosphorylates ribosomal protein in vitro. Activation of AtS6k is regulated by 1-naphthylacetic acid and kinetin, at least in part, via a lipid kinase-dependent pathway. Involved in translational up-regulation of ribosomal proteins. Phosphorylated by PDK1. Interacts with RAPTOR1, which in turn interacts with TOR. SPK6 activity is affected by osmotic stress, and plants overexpressing S6k1 are hypersensitive to osmotic stress. The gene is expressed in all tissues examined, with highest expression level detected in metabolically active tissues.
Computational
Description (TAIR10)
protein-serine kinase 1 (PK1); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase, C-terminal (InterPro:IPR017892), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), AGC-kinase, C-terminal (InterPro:IPR000961), Protein kinase, catalytic domain (InterPro:IPR000719); BEST Arabidopsis thaliana protein match is: serine/threonine protein kinase 2 (TAIR:AT3G08720.2); Has 134224 Blast hits to 132007 proteins in 4588 species: Archae - 200; Bacteria - 15979; Metazoa - 48799; Fungi - 13454; Plants - 32927; Viruses - 586; Other Eukaryotes - 22279 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT3G08730-MONOMERBioGrid:5355BRENDA:2.7.11.1EC:2.7.11.1
eggNOG:ENOG410XNPHeggNOG:KOG0598EMBL:AC012562EMBL:AY065230
EMBL:AY084935EMBL:AY096555EMBL:CP002686EMBL:D42056
EMBL:L29030EnsemblPlants:AT3G08730EnsemblPlants:AT3G08730.1entrez:820020
GeneID:820020Genevisible:P42818GO:GO:0004672GO:GO:0004674
GO:GO:0005524GO:GO:0005634GO:GO:0005737GO:GO:0006468
GO:GO:0006970GO:GO:0008285GO:GO:0009409GO:GO:0009651
GO:GO:0016301GO:GO:0035556GO:GO:0045727Gramene:AT3G08730.1
hmmpanther:PTHR24351hmmpanther:PTHR24351:SF80HOGENOM:HOG000233033InParanoid:P42818
IntAct:P42818InterPro:IPR000719InterPro:IPR000961InterPro:IPR008271
InterPro:IPR011009InterPro:IPR017441InterPro:IPR017892iPTMnet:P42818
KEGG:ath:AT3G08730KO:K04688MINT:MINT-8050626OMA:ECLEGES
PaxDb:P42818Pfam:P42818Pfam:PF00069Pfam:PF00433
Pfscan:PS50011Pfscan:PS51285PhylomeDB:P42818PIR:S68462
PRIDE:P42818PRO:PR:P42818PROSITE:PS00107PROSITE:PS00108
PROSITE:PS50011PROSITE:PS51285ProteinModelPortal:P42818Proteomes:UP000006548
Reactome:R-ATH-166208RefSeq:NP_187485.1scanprosite:PS00107scanprosite:PS00108
SMART:SM00133SMART:SM00220SMR:P42818STRING:3702.AT3G08730.1
SUPFAM:SSF56112TAIR:AT3G08730tair10-symbols:ATPK1tair10-symbols:ATPK6
tair10-symbols:ATS6K1tair10-symbols:PK1tair10-symbols:PK6tair10-symbols:S6K1
UniGene:At.23700UniProt:P42818
Coordinates (TAIR10) chr3:-:2651581..2653363
Molecular Weight (calculated) 52590.80 Da
IEP (calculated) 6.13
GRAVY (calculated) -0.44
Length 465 amino acids
Sequence (TAIR10)
(BLAST)
001: MVSSQRPVPN KIQKQQYLSI SPSNSVLKDD VELEFSDVFG PLPEEANDIA YDEPAVVYSR SHSLVGPCSL DSHSLKLTKL TLLETEDSID LVECLEGESL
101: KENDDFSGND DSDNEKALEG DLVKVSGVVG IDDFEVMKVV GKGAFGKVYQ VRKKETSEIY AMKVMRKDHI MEKNHAEYMK AERDILTKID HPFIVQLKYS
201: FQTKYRLYLV LDFINGGHLF FQLYHQGLFR EDLARVYTAE IVSAVSHLHE KGIMHRDLKP ENILMDTDGH VMLTDFGLAK EFEENTRSNS MCGTTEYMAP
301: EIVRGKGHDK AADWWSVGIL LYEMLTGKPP FLGSKGKIQQ KIVKDKIKLP QFLSNEAHAI LKGLLQKEPE RRLGSGLSGA EEIKQHKWFK GINWKKLEAR
401: EVMPSFKPEV SGRQCIANFD KCWTDMSVLD SPASSPSSDP KANPFTNFTY VRPPPSFLHQ STTTL
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)