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AT3G03300.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
nucleus 0.978
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : dicer-like 2
Curator
Summary (TAIR10)
Encodes a Dicer-like protein that functions in the antiviral silencing response in turnip-crinkle virus-infected plants but not in TMV or CMV-strain-Y-infected plants. Involved in the production of ta-siRNAs. Partially antagonizes the production of miRNAs by DCL1. Substitutes for DCL4 to produce viral siRNA when DCL4 is missing or inhibited. Able to produce siRNAs but not miRNAs.
Computational
Description (TAIR10)
dicer-like 2 (DCL2); FUNCTIONS IN: in 7 functions; INVOLVED IN: defense response to virus, maintenance of DNA methylation, production of ta-siRNAs involved in RNA interference; LOCATED IN: intracellular; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), Double-stranded RNA-binding (InterPro:IPR001159), Argonaute/Dicer protein, PAZ (InterPro:IPR003100), Ribonuclease III (InterPro:IPR000999), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Dicer double-stranded RNA-binding fold (InterPro:IPR005034), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: dicer-like 4 (TAIR:AT5G20320.1); Has 12581 Blast hits to 11282 proteins in 2839 species: Archae - 320; Bacteria - 5925; Metazoa - 2075; Fungi - 1253; Plants - 706; Viruses - 26; Other Eukaryotes - 2276 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT3G03300-MONOMERBioCyc:ARA:GQT-1567-MONOMEREC:3.1.26.-eggNOG:COG0571eggNOG:COG1111eggNOG:KOG0701EMBL:AC012328
EMBL:CP002686EMBL:DQ479970EMBL:DQ479971EnsemblPlants:AT3G03300EnsemblPlants:AT3G03300.1EnsemblPlants:AT3G03300.3entrez:821300
Gene3D:1.10.1520.10Gene3D:3.40.50.300GeneID:821300Genevisible:Q3EBC8GO:GO:0003723GO:GO:0004386GO:GO:0004525
GO:GO:0005524GO:GO:0005634GO:GO:0005737GO:GO:0010216GO:GO:0010267GO:GO:0016442GO:GO:0046872
GO:GO:0051607GO:GO:0090501GO:GO:0090502hmmpanther:PTHR14950hmmpanther:PTHR14950:SF19HOGENOM:HOG000006099InParanoid:Q3EBC8
IntAct:Q3EBC8InterPro:IPR000999InterPro:IPR001650InterPro:IPR003100InterPro:IPR005034InterPro:IPR011545InterPro:IPR014001
InterPro:IPR014720InterPro:IPR027417iPTMnet:Q3EBC8KEGG:ath:AT3G03300KO:K11592OMA:HANILSCPaxDb:Q3EBC8
Pfam:PF00270Pfam:PF00271Pfam:PF00636Pfam:PF02170Pfam:PF03368Pfam:Q3EBC8Pfscan:PS50137
Pfscan:PS50142Pfscan:PS50821Pfscan:PS51192Pfscan:PS51194Pfscan:PS51327PhylomeDB:Q3EBC8PRIDE:Q3EBC8
PRO:PR:Q3EBC8PROSITE:PS00517PROSITE:PS50137PROSITE:PS50142PROSITE:PS50821PROSITE:PS51192PROSITE:PS51194
PROSITE:PS51327ProteinModelPortal:Q3EBC8Proteomes:UP000006548RefSeq:NP_001078101.1RefSeq:NP_001189798.1RefSeq:NP_566199.4scanprosite:PS00517
SMART:SM00358SMART:SM00487SMART:SM00490SMART:SM00535SMART:SM00949SMR:Q3EBC8STRING:3702.AT3G03300.1
SUPFAM:SSF101690SUPFAM:SSF52540SUPFAM:SSF54768SUPFAM:SSF69065TAIR:AT3G03300tair10-symbols:ATDCL2tair10-symbols:DCL2
UniGene:At.43488UniProt:Q3EBC8
Coordinates (TAIR10) chr3:-:768020..774833
Molecular Weight (calculated) 156873.00 Da
IEP (calculated) 6.77
GRAVY (calculated) -0.13
Length 1388 amino acids
Sequence (TAIR10)
(BLAST)
0001: MTMDADAMET ETTDQVSASP LHFARSYQVE ALEKAIKQNT IVFLETGSGK TLIAIMLLRS YAYLFRKPSP CFCVFLVPQV VLVTQQAEAL KMHTDLKVGM
0101: YWGDMGVDFW DSSTWKQEVD KYEVLVMTPA ILLDALRHSF LSLSMIKVLI VDECHHAGGK HPYACIMREF YHKELNSGTS NVPRIFGMTA SLVKTKGENL
0201: DSYWKKIHEL ETLMNSKVYT CENESVLAGF VPFSTPSFKY YQHIKIPSPK RASLVEKLER LTIKHRLSLG TLDLNSSTVD SVEKRLLRIS STLTYCLDDL
0301: GILLAQKAAQ SLSASQNDSF LWGELNMFSV ALVKKFCSDA SQEFLAEIPQ GLNWSVANIN GNAEAGLLTL KTVCLIETLL GYSSLENIRC IIFVDRVITA
0401: IVLESLLAEI LPNCNNWKTK YVAGNNSGLQ NQTRKKQNEI VEDFRRGLVN IIVATSILEE GLDVQSCNLV IRFDPASNIC SFIQSRGRAR MQNSDYLMMV
0501: ESGDLLTQSR LMKYLSGGKR MREESLDHSL VPCPPLPDDS DEPLFRVEST GATVTLSSSV SLIYHYCSRL PSDEYFKPAP RFDVNKDQGS CTLYLPKSCP
0601: VKEVKAEANN KVLKQAVCLK ACIQLHKVGA LSDHLVPDMV VAETVSQKLE KIQYNTEQPC YFPPELVSQF SAQPETTYHF YLIRMKPNSP RNFHLNDVLL
0701: GTRVVLEDDI GNTSFRLEDH RGTIAVTLSY VGAFHLTQEE VLFCRRFQIT LFRVLLDHSV ENLMEALNGL HLRDGVALDY LLVPSTHSHE TSLIDWEVIR
0801: SVNLTSHEVL EKHENCSTNG ASRILHTKDG LFCTCVVQNA LVYTPHNGYV YCTKGVLNNL NGNSLLTKRN SGDQTYIEYY EERHGIQLNF VDEPLLNGRH
0901: IFTLHSYLHM AKKKKEKEHD REFVELPPEL CHVILSPISV DMIYSYTFIP SVMQRIESLL IAYNLKKSIP KVNIPTIKVL EAITTKKCED QFHLESLETL
1001: GDSFLKYAVC QQLFQHCHTH HEGLLSTKKD GMISNVMLCQ FGCQQKLQGF IRDECFEPKG WMVPGQSSAA YSLVNDTLPE SRNIYVASRR NLKRKSVADV
1101: VESLIGAYLS EGGELAALMF MNWVGIKVDF TTTKIQRDSP IQAEKLVNVG YMESLLNYSF EDKSLLVEAL THGSYMMPEI PRCYQRLEFL GDSVLDYLIT
1201: KHLYDKYPCL SPGLLTDMRS ASVNNECYAL VAVKANLHKH ILYASHHLHK HISRTVSEFE QSSLQSTFGW ESDISFPKVL GDVIESLAGA IFVDSGYNKE
1301: VVFASIKPLL GCMITPETVK LHPVRELTEL CQKWQFELSK AKDFDSFTVE VKAKEMSFAH TAKASDKKMA KKLAYKEVLN LLKNSLDY
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)