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AT2G46450.1
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
plasma membrane 0.983
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : cyclic nucleotide-gated channel 12
Curator
Summary (TAIR10)
Member of Cyclic nucleotide gated channel family.Positive regulator of resistance against avirulent fungal pathogen.Suppresses the phenotype conferred by cpr22 in a dosage-dependent manner.
Computational
Description (TAIR10)
cyclic nucleotide-gated channel 12 (CNGC12); CONTAINS InterPro DOMAIN/s: Cyclic nucleotide-binding (InterPro:IPR000595), Ion transport (InterPro:IPR005821), Cyclic nucleotide-binding-like (InterPro:IPR018490), RmlC-like jelly roll fold (InterPro:IPR014710), IQ calmodulin-binding region (InterPro:IPR000048); BEST Arabidopsis thaliana protein match is: cyclic nucleotide-gated channels (TAIR:AT2G46440.1); Has 2667 Blast hits to 2622 proteins in 213 species: Archae - 0; Bacteria - 16; Metazoa - 1408; Fungi - 0; Plants - 925; Viruses - 0; Other Eukaryotes - 318 (source: NCBI BLink).
Protein Annotations
eggNOG:ENOG410XPSEeggNOG:KOG0498EMBL:AC006526EMBL:AK118918
EMBL:CP002685EnsemblPlants:AT2G46450EnsemblPlants:AT2G46450.1entrez:819253
ExpressionAtlas:Q8GWD2Gene3D:2.60.120.10GeneID:819253Genevisible:Q8GWD2
GO:GO:0005249GO:GO:0005261GO:GO:0005886GO:GO:0006952
GO:GO:0009617GO:GO:0009620GO:GO:0016021GO:GO:0030552
GO:GO:0030553GO:GO:0042391GO:GO:0071805GO:GO:0098655
hmmpanther:PTHR10217hmmpanther:PTHR10217:SF465HOGENOM:HOG000238338InParanoid:Q8GWD2
InterPro:IPR000048InterPro:IPR000595InterPro:IPR005821InterPro:IPR014710
InterPro:IPR018490iPTMnet:Q8GWD2OMA:RVKSVFYPaxDb:Q8GWD2
Pfam:PF00520Pfam:Q8GWD2Pfscan:PS50042Pfscan:PS50096
PhylomeDB:Q8GWD2PIR:A84903PRIDE:Q8GWD2PRO:PR:Q8GWD2
PROSITE:PS50042PROSITE:PS50096ProteinModelPortal:Q8GWD2Proteomes:UP000006548
Reactome:R-ATH-2485179Reactome:R-ATH-2514859Reactome:R-ATH-5620916RefSeq:NP_850454.5
SMART:SM00100SMR:Q8GWD2STRING:3702.AT2G46450.1SUPFAM:SSF51206
SUPFAM:SSF81324TAIR:AT2G46450tair10-symbols:ATCNGC12tair10-symbols:CNGC12
TMHMM:TMhelixUniGene:At.36508UniGene:At.50596UniProt:Q8GWD2
Coordinates (TAIR10) chr2:+:19065845..19068364
Molecular Weight (calculated) 74810.50 Da
IEP (calculated) 9.79
GRAVY (calculated) -0.06
Length 649 amino acids
Sequence (TAIR10)
(BLAST)
001: MNHRRSKFAR IDSMGVDGKL KSVRGRLKKV YGKMKTLENW RKTVLLACVV ALAIDPLFLF IPLIDSQRFC FTFDKTLVAV VCVIRTFIDT FYVIHIIYYL
101: ITETIAPRSQ ASLRGEIVVH SKATLKTRLL FHFIVDIISV LPIPQVVVLT LIPLSASLVS ERILKWIILS QYVPRIIRMY PLYKEVTRAF GTVAESKWAG
201: AALNLFLYML HSYVFGAFWY LSSIERKSKC WRAACARTSD CNLTVTDLLC KRAGSDNIRF LNTSCPLIDP AQITNSTDFD FGMYIDALKS GVLEVKPKDF
301: PRKFVYCFWW GLRNISALGQ NLETSNSAGE IFFAIIICVS GLLLFAVLIG NVQKYLQSST TRVDEMEEKR RDTEKWMSYR VIPEYLKERI RRFEDYKWRE
401: TKGTEEEALL RSLPKDLRLE TKRYLYLDML KRVPWLNIMD DGWLLEAVCD RVKSVFYLAN SFIVREGHPV EEMLIVTRGK LKSTTGSHEM GVRNNCCDLQ
501: DGDICGELLF NGSRLPTSTR TVMTLTEVEG FILLPDDIKF IASHLNVFQR QKLQRTFRLY SQQWRSWAAF FIQAAWRKHC KRKLSKTRDN ENIPQGTQLN
601: LASTLYVSRF VSKALQNRRK DTADCSSSPD MSPPVPHKPA DLEFAKAEA
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)