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AT2G46070.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
cytosol 0.853
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : mitogen-activated protein kinase 12
Curator
Summary (TAIR10)
Encodes a MAP kinase protein. MPK12 interacts with the IBR5 protein phosphatase in vitro and in vivo, and it can be dephosphorylated and inactivated by IBR5. MPK12 appears to be a negative regulator of auxin signlaing. MPK12 RNAi lines are hypersensitive to auxin in root elongation and transcriptional response assays, but they appear to have normal sensitivity to ABA. MPK12 is a nuclear protein and its kinase activity is increased following auxin treatment. MPK12 transcripts are widely expressed in seedlings, but MPK12 expression is stronger in guard cells than in other cell types in mature plants.
Computational
Description (TAIR10)
mitogen-activated protein kinase 12 (MPK12); CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), JNK MAP kinase (InterPro:IPR008351), Serine/threonine-protein kinase domain (InterPro:IPR002290), Tyrosine-protein kinase, active site (InterPro:IPR008266), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: MAP kinase 4 (TAIR:AT4G01370.1); Has 125734 Blast hits to 124415 proteins in 4732 species: Archae - 106; Bacteria - 13752; Metazoa - 47505; Fungi - 12616; Plants - 30542; Viruses - 578; Other Eukaryotes - 20635 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT2G46070-MONOMERBioCyc:ARA:GQT-1132-MONOMERBioGrid:4550EC:2.7.11.24eggNOG:ENOG410XNY0eggNOG:KOG0660EMBL:AC005397
EMBL:AK117449EMBL:BT024898EMBL:CP002685EnsemblPlants:AT2G46070EnsemblPlants:AT2G46070.1entrez:819215ExpressionAtlas:Q8GYQ5
GeneID:819215Genevisible:Q8GYQ5GO:GO:0000165GO:GO:0004707GO:GO:0005524GO:GO:0005634GO:GO:0009733
GO:GO:0009734GO:GO:0016301GO:GO:0035556GO:GO:0080026hmmpanther:PTHR24055hmmpanther:PTHR24055:SF227HOGENOM:HOG000233024
InParanoid:Q8GYQ5IntAct:Q8GYQ5InterPro:IPR000719InterPro:IPR008266InterPro:IPR011009InterPro:IPR020635OMA:KQQFAAR
PaxDb:Q8GYQ5Pfam:PF00069Pfam:Q8GYQ5Pfscan:PS50011PhylomeDB:Q8GYQ5PIR:D84898PRIDE:Q8GYQ5
PRO:PR:Q8GYQ5PROSITE:PS50011ProteinModelPortal:Q8GYQ5Proteomes:UP000006548Reactome:R-ATH-110056Reactome:R-ATH-112409Reactome:R-ATH-112411
Reactome:R-ATH-198753Reactome:R-ATH-198765Reactome:R-ATH-202670Reactome:R-ATH-3371453Reactome:R-ATH-442742Reactome:R-ATH-445144Reactome:R-ATH-5673001
Reactome:R-ATH-5674135Reactome:R-ATH-5674499RefSeq:NP_182131.2scanprosite:PS00109SMART:SM00219SMR:Q8GYQ5STRING:3702.AT2G46070.1
SUPFAM:SSF56112TAIR:AT2G46070tair10-symbols:ATMPK12tair10-symbols:MAPK12tair10-symbols:MPK12UniGene:At.36555UniProt:Q8GYQ5
Coordinates (TAIR10) chr2:-:18946134..18947770
Molecular Weight (calculated) 42477.10 Da
IEP (calculated) 8.02
GRAVY (calculated) -0.30
Length 372 amino acids
Sequence (TAIR10)
(BLAST)
001: MSGESSSGST EHCIKVVPTH GGRYVQYNVY GQLFEVSRKY VPPIRPIGRG ACGIVCAAVN SVTGEKVAIK KIGNAFDNII DAKRTLREIK LLRHMDHENV
101: ITIKDIVRPP QRDIFNDVYI VYELMDTDLQ RILRSNQTLT SDQCRFLVYQ LLRGLKYVHS ANILHRDLRP SNVLLNSKNE LKIGDFGLAR TTSDTDFMTE
201: YVVTRWYRAP ELLLNCSEYT AAIDIWSVGC ILGEIMTGQP LFPGKDYVHQ LRLITELVGS PDNSSLGFLR SDNARRYVRQ LPRYPKQQFA ARFPKMPTTA
301: IDLLERMLVF DPNRRISVDE ALGHAYLSPH HDVAKEPVCS TPFSFDFEHP SCTEEHIKEL IYKESVKFNP DH
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)