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AT2G31660.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
cytosol 0.500
nucleus 0.500
ASURE: cytosol,nucleus
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:25900983 (2015): Golgi
  • PMID:25900983 (2015): Golgi Golgi apparatus Golgi membrane
  • PMID:25900983 (2015): Golgi trans-Golgi network
  • PMID:25900983 (2015): Golgi trans-Golgi network early endosome
  • PMID:25900983 (2015): Golgi trans-Golgi network multivesicular body
  • PMID:25900983 (2015): plant-type vacuole plant-type vacuole membrane
  • PMID:21166475 (2011): cytosol
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : ARM repeat superfamily protein
Curator
Summary (TAIR10)
SAD2 (super sensitive to ABA and drought 2) encodes an importin beta-domain family protein likely to be involved in nuclear transport in ABA signaling. Subcellular localization of GFP-tagged SAD2 showed a predominantly nuclear localization, consistent with a role for SAD2 in nuclear transport. Mutation of SAD2 in Arabidopsis alters abscisic acid sensitivity. SAD2 was ubiquitously expressed at low levels in all tissues except flowers. SAD2 expression was not induced by ABA or stress. Loss of function mutations in SAD2 exhibit increased tolerance for UV stress, increased production of UV protective secondary metabolites and suppression of nuclear localization of MYB4 (a repressor of UV stress response genes).
Computational
Description (TAIR10)
SUPER SENSITIVE TO ABA AND DROUGHT2 (SAD2); FUNCTIONS IN: protein transporter activity, binding; INVOLVED IN: protein import into nucleus, docking, protein import into nucleus; LOCATED IN: nucleus, nuclear pore, cytoplasm; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Importin-beta, N-terminal (InterPro:IPR001494), Armadillo-like helical (InterPro:IPR011989), Armadillo-type fold (InterPro:IPR016024), Exportin/Importin, Cse1-like (InterPro:IPR013713); BEST Arabidopsis thaliana protein match is: ARM repeat superfamily protein (TAIR:AT3G59020.1); Has 3689 Blast hits to 2792 proteins in 293 species: Archae - 3; Bacteria - 183; Metazoa - 1271; Fungi - 834; Plants - 368; Viruses - 60; Other Eukaryotes - 970 (source: NCBI BLink).
Protein Annotations
eggNOG:COG5656eggNOG:KOG1991EMBL:AC007071EMBL:AK117271EMBL:AK222176EMBL:CP002685EnsemblPlants:AT2G31660
EnsemblPlants:AT2G31660.1entrez:817722Gene3D:1.25.10.10GeneID:817722Genevisible:F4IRR2GO:GO:0005634GO:GO:0005635
GO:GO:0005737GO:GO:0005829GO:GO:0006606GO:GO:0007165GO:GO:0008565GO:GO:0035280Gramene:AT2G31660.1
hmmpanther:PTHR10997hmmpanther:PTHR10997:SF35HOGENOM:HOG000265678InParanoid:F4IRR2InterPro:IPR001494InterPro:IPR011989InterPro:IPR013713
InterPro:IPR016024KEGG:ath:AT2G31660ncoils:CoilOMA:QTQAKEYPaxDb:F4IRR2Pfam:F4IRR2Pfam:PF03810
Pfam:PF08506Pfscan:PS50166PIR:E84723PRIDE:F4IRR2PRO:PR:F4IRR2ProMEX:F4IRR2PROSITE:PS50166
ProteinModelPortal:F4IRR2Proteomes:UP000006548Reactome:R-ATH-5578749RefSeq:NP_180724.2SMART:SM00913SMR:F4IRR2STRING:3702.AT2G31660.1
SUPFAM:SSF48371TAIR:AT2G31660tair10-symbols:SAD2tair10-symbols:URM9UniGene:At.46140UniProt:F4IRR2
Coordinates (TAIR10) chr2:+:13464519..13471353
Molecular Weight (calculated) 119254.00 Da
IEP (calculated) 4.51
GRAVY (calculated) -0.22
Length 1040 amino acids
Sequence (TAIR10)
(BLAST)
0001: MDLHSLALIL RTAALSPIPD ERKVSEQQLN QLEHTPQHLV RLLQIAVDGN CDMAVRQIAS IQFKNLIAKN WSPEDCGPAV RQQQIFESDK ELVRDNILVY
0101: VTQVPTLLRS QLGESLKTII YADYPEQWPR LLDWVKYNLQ NQQIYGALFV LRILSRKYEF KSDEERTPVS RIVEETFPQL LTIFNGLIQI PNPSLEIAEL
0201: MKLICKIFWS SIYLELPRQL FDLNVFNAWM VLFLSVSERP VPVEGQPMDP ELRKSWGWWK VKKWTVHILN RLYSRFGDPK LQSPENKPFA QMFQKNYAGR
0301: ILEGHLNFLN TIRVGGYLPD RVINLLLQYL SNSISKNSMY KLLLPRLDVL LFEIVFPLMC FNDNDQKLWE EDPHEYVRKG YNIIEDLYSP RTASMDFVNE
0401: LVRKRGKENL PKFVKFVVEI FLSYEKATVE EKPYRQKDGA MLAVGALCDK LKQTDPYKSQ LELMLVQHIF PDFNSPVGHL RAKAAWVAGQ YAHINFSDQN
0501: NFRKALHSVV SGLRDPDLPV RVDSVFALRS FVEACKDLNE IRPILPQLLD EFFKLMNEVE NEDLVFTLET IVDKFGEEMA PFAFGLCQNL AAAFWRCLNT
0601: SEANDDSDDM GALAAVGCLR AISTILESVS SLPQLFVEIE PTILPIMQKM LTTDGQEVFE EVLEIASYMT FYSPSISLDI WSLWPLMVEA LVDWGIDFFP
0701: NILVPMDNFI SRGTAHFLTC KEPDYQQSLY NVLSTLMTDR NIEDSEIESA PKLIEVVFQN CKGQVDQWVE PYLRLTVDRL QRAETSYVKS LLIQVVANML
0801: YYNPGLTLGV LHNTGLASKV FDLWFQMLQQ KRKSGLPANF KREHDKKVCC LGLTSLLALP GGQFPDEALQ RVFRATLDLL VAYKNQLAEA AKETEVDYEE
0901: EMNGLQSSDD DYDDDGSDGE MDDTEEGDEA QSVKLQKLAA QAKAFHYDDD DDDDSDDDFS DEDEFQSPID EVDAFVFFVD AIRVMQASDA QRFQNLNQSL
1001: DFTYQAIANG IAQHAELRRV EIEKEKQKKL AAASTPVTAL
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)