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AT2G19110.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
plasma membrane 1.000
ASURE: plasma membrane
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : heavy metal atpase 4
Curator
Summary (TAIR10)
Encodes a protein with similarity to Zn ATPase. Can rescue Zn deficiency in yeast and Cd resistance, suggesting a role in Zn and Cd transport.
Computational
Description (TAIR10)
heavy metal atpase 4 (HMA4); FUNCTIONS IN: zinc ion transmembrane transporter activity, protein binding, cadmium ion transmembrane transporter activity, cadmium-transporting ATPase activity; INVOLVED IN: in 8 processes; LOCATED IN: plasma membrane; EXPRESSED IN: 30 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, P-type copper-transporter (InterPro:IPR001756), Heavy metal transport/detoxification protein (InterPro:IPR006121), ATPase, P-type, ATPase-associated domain (InterPro:IPR008250), ATPase, P-type, heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating (InterPro:IPR006404), Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), ATPase, P-type, heavy metal translocating (InterPro:IPR006416), ATPase, P-type phosphorylation site (InterPro:IPR018303); BEST Arabidopsis thaliana protein match is: heavy metal atpase 2 (TAIR:AT4G30110.1); Has 40067 Blast hits to 31648 proteins in 3107 species: Archae - 784; Bacteria - 26302; Metazoa - 4194; Fungi - 2461; Plants - 1970; Viruses - 7; Other Eukaryotes - 4349 (source: NCBI BLink).
Protein Annotations
eggNOG:COG2217eggNOG:KOG0207EMBL:AK227102EnsemblPlants:AT2G19110EnsemblPlants:AT2G19110.1entrez:816428ExpressionAtlas:Q0WUP4
Gene3D:2.70.150.10Gene3D:3.40.1110.10Gene3D:3.40.50.1000GeneID:816428GO:GO:0000166GO:GO:0016021GO:GO:0019829
GO:GO:0030001GO:GO:0046872Gramene:AT2G19110.1InterPro:IPR001757InterPro:IPR006121InterPro:IPR008250InterPro:IPR018303
InterPro:IPR023214InterPro:IPR023299InterPro:IPR027256KEGG:ath:AT2G19110KO:K01534OMA:KDEHCESPaxDb:Q0WUP4
PDB:2KKHPfam:O64474Pfam:PF00122Pfam:PF00702Pfscan:PS50846PhylomeDB:Q0WUP4PRIDE:Q0WUP4
PROSITE:PS00154PROSITE:PS50846ProteinModelPortal:Q0WUP4RefSeq:NP_179501.1scanprosite:PS00154SMR:Q0WUP4STRING:3702.AT2G19110.1
SUPFAM:0049471SUPFAM:0049473SUPFAM:SSF55008SUPFAM:SSF56784TAIR:AT2G19110tair10-symbols:ATHMA4tair10-symbols:HMA4
TIGRfam:TIGR01494TIGRfam:TIGR01512TIGRfam:TIGR01525TIGRFAMs:TIGR01494TIGRFAMs:TIGR01525TMHMM:TMhelixUniGene:At.25023
UniProt:O64474UniProt:Q0WUP4
Coordinates (TAIR10) chr2:+:8279478..8286255
Molecular Weight (calculated) 127216.00 Da
IEP (calculated) 7.25
GRAVY (calculated) -0.16
Length 1172 amino acids
Sequence (TAIR10)
(BLAST)
0001: MALQNKEEEK KKVKKLQKSY FDVLGICCTS EVPIIENILK SLDGVKEYSV IVPSRTVIVV HDSLLISPFQ IAKALNEARL EANVRVNGET SFKNKWPSPF
0101: AVVSGLLLLL SFLKFVYSPL RWLAVAAVAA GIYPILAKAF ASIKRPRIDI NILVIITVIA TLAMQDFMEA AAVVFLFTIS DWLETRASYK ATSVMQSLMS
0201: LAPQKAIIAE TGEEVEVDEV KVDTVVAVKA GETIPIDGIV VDGNCEVDEK TLTGEAFPVP KQRDSTVWAG TINLNGYICV KTTSLAGDCV VAKMAKLVEE
0301: AQSSKTKSQR LIDKCSQYYT PAIILVSACV AIVPVIMKVH NLKHWFHLAL VVLVSGCPCG LILSTPVATF CALTKAATSG LLIKSADYLD TLSKIKIVAF
0401: DKTGTITRGE FIVIDFKSLS RDINLRSLLY WVSSVESKSS HPMAATIVDY AKSVSVEPRP EEVEDYQNFP GEGIYGKIDG NDIFIGNKKI ASRAGCSTVP
0501: EIEVDTKGGK TVGYVYVGER LAGFFNLSDA CRSGVSQAMA ELKSLGIKTA MLTGDNQAAA MHAQEQLGNV LDVVHGDLLP EDKSRIIQEF KKEGPTAMVG
0601: DGVNDAPALA TADIGISMGI SGSALATQTG NIILMSNDIR RIPQAVKLAR RARRKVVENV CLSIILKAGI LALAFAGHPL IWAAVLVDVG TCLLVIFNSM
0701: LLLREKKKIG NKKCYRASTS KLNGRKLEGD DDYVVDLEAG LLTKSGNGQC KSSCCGDKKN QENVVMMKPS SKTSSDHSHP GCCGDKKEEK VKPLVKDGCC
0801: SEKTRKSEGD MVSLSSCKKS SHVKHDLKMK GGSGCCASKN EKGKEVVAKS CCEKPKQQVE SVGDCKSGHC EKKKQAEDIV VPVQIIGHAL THVEIELQTK
0901: ETCKTSCCDS KEKVKETGLL LSSENTPYLE KGVLIKDEGN CKSGSENMGT VKQSCHEKGC SDEKQTGEIT LASEEETDDQ DCSSGCCVNE GTVKQSFDEK
1001: KHSVLVEKEG LDMETGFCCD AKLVCCGNTE GEVKEQCRLE IKKEEHCKSG CCGEEIQTGE ITLVSEEETE STNCSTGCCV DKEEVTQTCH EKPASLVVSG
1101: LEVKKDEHCE SSHRAVKVET CCKVKIPEAC ASKCRDRAKR HSGKSCCRSY AKELCSHRHH HHHHHHHHHV SA
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)