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AT2G17520.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
endoplasmic reticulum 1.000
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : Endoribonuclease/protein kinase IRE1-like
Curator
Summary (TAIR10)
Encodes a endoribonuclease/protein kinase IRE1-like protein that is predicted to form a type I transmembrane protein structure and contain kinase/endoribonuclease domains at their C-terminal halves. The transcript levels for several ER-stress responsive genes, including six protein disulfide isomerases (PDIs), BiP2, and AtbZIP60 are not affected in ire1-2 null mutants.
Computational
Description (TAIR10)
IRE1A; CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), KEN domain, ribonuclease activator (InterPro:IPR010513), PUG domain (InterPro:IPR006567), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: inositol requiring 1-1 (TAIR:AT5G24360.1); Has 104790 Blast hits to 103944 proteins in 4127 species: Archae - 110; Bacteria - 12550; Metazoa - 37627; Fungi - 10369; Plants - 27162; Viruses - 328; Other Eukaryotes - 16644 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT2G17520-MONOMERBioGrid:1615EC:2.7.11.1EC:3.1.26.-eggNOG:COG0515eggNOG:KOG1027EMBL:AB049937
EMBL:AC007584EMBL:AF308596EMBL:AK222006EMBL:AK228980EMBL:CP002685EnsemblPlants:AT2G17520EnsemblPlants:AT2G17520.1
entrez:816258GeneID:816258Genevisible:Q9C5S2GO:GO:0004521GO:GO:0004674GO:GO:0005524GO:GO:0005783
GO:GO:0006351GO:GO:0006355GO:GO:0006397GO:GO:0006987GO:GO:0008380GO:GO:0009751GO:GO:0009816
GO:GO:0016021GO:GO:0030968GO:GO:0042406GO:GO:0046777GO:GO:0046872GO:GO:0090502Gramene:AT2G17520.1
hmmpanther:PTHR13954hmmpanther:PTHR13954:SF13HOGENOM:HOG000084349InParanoid:Q9C5S2InterPro:IPR000719InterPro:IPR008271InterPro:IPR010513
InterPro:IPR011009InterPro:IPR018997KEGG:04150+2.7.11.1KEGG:04151+2.7.11.1KEGG:ath:AT2G17520KO:K08852OMA:HEVAFKE
PaxDb:Q9C5S2Pfam:PF00069Pfam:PF06479Pfam:Q9C5S2Pfscan:PS50011Pfscan:PS51392PhylomeDB:Q9C5S2
PIR:B84553PRIDE:Q9C5S2PRO:PR:Q9C5S2PROSITE:PS00108PROSITE:PS50011PROSITE:PS51392ProteinModelPortal:Q9C5S2
Proteomes:UP000006548Reactome:R-ATH-381070RefSeq:NP_565419.1scanprosite:PS00108SMART:SM00220SMART:SM00580SMR:Q9C5S2
STRING:3702.AT2G17520.1SUPFAM:SSF56112TAIR:AT2G17520tair10-symbols:ATIRE1-2tair10-symbols:IRE1-2tair10-symbols:IRE1AUniGene:At.14585
UniProt:Q9C5S2
Coordinates (TAIR10) chr2:+:7617504..7620929
Molecular Weight (calculated) 95143.70 Da
IEP (calculated) 8.65
GRAVY (calculated) -0.32
Length 841 amino acids
Sequence (TAIR10)
(BLAST)
001: MPPRCPFLRH LFFLLLLLSP WIMSPCGGAA DDVTYPIVPS SPGRRSILQI RREPPTEPNT KLVVDRDGKV FLKQQPKETP YWSFSTGSPM HSLYQAPANN
101: NTENATEITR PHIIVEYLNN SKAATTVDGY HNWTVQEFFR QKPLVTDDGV TLGSETTSAY LVDGRSGRLI HVYKSTGDTK ITNALVKPAS TEDFVNEPLL
201: IRRTDSKLEH FSKTTGKLVW NLTVSHFRAA LLCDPVFNSG YDLGPKLQTG IYMPLLCGSQ IDVRGPEIVI RVLHDQPMNV KMLPSPSLNH FESENSIMPF
301: GKARESRKLQ EQHKQKYTYL FGQWSPVKLL APLVLLGVVV SVFIKKFSSR GSDVSLKAGP SKKKKNRKSA KDTNRQSVPR GQDQFELIEG GQMLLGFNNF
401: QSGATDGRKI GKLFLSSKEI AKGSNGTVVF EGIYEGRPVA VKRLVRSHHE VAFKEIQNLI ASDQHTNIIR WYGVEYDQDF VYLSLERCTC SLDDLIKSYL
501: EFSMTKVLEN NDSTEGVAAY KIQLDSLEGV IKGNNFWKVG GHPSPLMLKL MRDIVCGIVH LHELGIVHRD LKPQNVLISK DMTLSAKLSD MGISKRMSRD
601: MSSLGHLATG SGSSGWQAPE QLLQGRQTRA VDMFSLGCVI FYTITGCKHP FGDDLERDVN IVKNKVDLFL VEHVPEASDL ISRLLNPDPD LRPSATEVLL
701: HPMFWNSEMR LSFLRDASDR VELENREADS EILKAMESTA PVAIGGKWDE KLEPVFITNI GRYRRYKYDS IRDLLRVIRN KLNHHRELPP EIQELVGTVP
801: EGFDEYFAVR FPKLLIEVYR VISLHCREEE VFRKYFKCDI I
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)