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AT2G17290.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
cytosol 1.000
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : Calcium-dependent protein kinase family protein
Curator
Summary (TAIR10)
Encodes calcium dependent protein kinase 6 (CPK6), a member of the Arabidopsis CDPK gene family. CDPKs contain an intrinsic Ca2+-activation domain with four EF hand Ca2+-binding sites. CDPKs protein kinases have been proposed to function in multiple plant signal transduction pathways downstream of [Ca2+]cyt elevations, thus transducing various physiological responses. CPK6 is expressed in both guard cells and mesophyll cells. Functions in guard cell ion channel regulation. ABA and Ca(2+) activation of slow-type anion channels and, interestingly, ABA activation of plasma membrane Ca(2+)-permeable channels were impaired in independent alleles of single and double cpk3cpk6 mutant guard cells. Furthermore, ABA- and Ca(2+)-induced stomatal closing were partially impaired in these cpk3cpk6 mutant alleles. CPK3 is also a member of the Arabidopsis CDPK family.
Computational
Description (TAIR10)
calcium dependent protein kinase 6 (CPK6); FUNCTIONS IN: in 6 functions; INVOLVED IN: regulation of anion channel activity, protein amino acid phosphorylation, N-terminal protein myristoylation, abscisic acid mediated signaling pathway, regulation of stomatal movement; LOCATED IN: cytosol, plasma membrane, membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), EF-Hand 1, calcium-binding site (InterPro:IPR018247), Serine/threonine-protein kinase domain (InterPro:IPR002290), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand (InterPro:IPR018248), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), EF-HAND 2 (InterPro:IPR018249), Calcium-dependent protein kinase (InterPro:IPR020642), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: calmodulin-domain protein kinase 5 (TAIR:AT4G35310.1); Has 133264 Blast hits to 125497 proteins in 3863 species: Archae - 149; Bacteria - 13464; Metazoa - 49073; Fungi - 17503; Plants - 30048; Viruses - 473; Other Eukaryotes - 22554 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT2G17290-MONOMERBioGrid:1592DIP:DIP-59319NEC:2.7.11.1eggNOG:ENOG410XRMJeggNOG:KOG0032EMBL:AY140007
EMBL:BT002600EMBL:CP002685EMBL:D28582EMBL:U31835EnsemblPlants:AT2G17290EnsemblPlants:AT2G17290.1entrez:816235
Gene3D:1.10.238.10GeneID:816235Genevisible:Q38872GO:GO:0004674GO:GO:0004683GO:GO:0005509GO:GO:0005516
GO:GO:0005524GO:GO:0005829GO:GO:0005886GO:GO:0009737GO:GO:0009738GO:GO:0009931GO:GO:0010119
GO:GO:0010359GO:GO:0016020GO:GO:0018105GO:GO:0035556GO:GO:0046777GO:GO:1902456Gramene:AT2G17290.1
hmmpanther:PTHR24349hmmpanther:PTHR24349:SF83HOGENOM:HOG000233030InParanoid:Q38872InterPro:IPR000719InterPro:IPR002048InterPro:IPR008271
InterPro:IPR011009InterPro:IPR011992InterPro:IPR017441InterPro:IPR018247iPTMnet:Q38872KEGG:ath:AT2G17290KO:K13412
OMA:KMLCSSPPaxDb:Q38872Pfam:PF00069Pfam:PF13499Pfam:Q38872Pfscan:PS50011Pfscan:PS50222
PhylomeDB:Q38872PIR:D84550PRIDE:Q38872PRO:PR:Q38872PROSITE:PS00018PROSITE:PS00107PROSITE:PS00108
PROSITE:PS50011PROSITE:PS50222ProteinModelPortal:Q38872Proteomes:UP000006548RefSeq:NP_565411.2scanprosite:PS00018scanprosite:PS00107
scanprosite:PS00108SMART:SM00054SMART:SM00220SMR:Q38872STRING:3702.AT2G17290.1SUPFAM:SSF47473SUPFAM:SSF56112
TAIR:AT2G17290tair10-symbols:ATCDPK3tair10-symbols:ATCPK6tair10-symbols:CPK6UniGene:At.9828UniProt:Q38872
Coordinates (TAIR10) chr2:+:7517005..7519239
Molecular Weight (calculated) 61114.90 Da
IEP (calculated) 5.39
GRAVY (calculated) -0.32
Length 544 amino acids
Sequence (TAIR10)
(BLAST)
001: MGNSCRGSFK DKIYEGNHSR PEENSKSTTT TVSSVHSPTT DQDFSKQNTN PALVIPVKEP IMRRNVDNQS YYVLGHKTPN IRDLYTLSRK LGQGQFGTTY
101: LCTDIATGVD YACKSISKRK LISKEDVEDV RREIQIMHHL AGHKNIVTIK GAYEDPLYVH IVMELCAGGE LFDRIIHRGH YSERKAAELT KIIVGVVEAC
201: HSLGVMHRDL KPENFLLVNK DDDFSLKAID FGLSVFFKPG QIFKDVVGSP YYVAPEVLLK HYGPEADVWT AGVILYILLS GVPPFWAETQ QGIFDAVLKG
301: YIDFDTDPWP VISDSAKDLI RKMLCSSPSE RLTAHEVLRH PWICENGVAP DRALDPAVLS RLKQFSAMNK LKKMALKVIA ESLSEEEIAG LRAMFEAMDT
401: DNSGAITFDE LKAGLRRYGS TLKDTEIRDL MEAADVDNSG TIDYSEFIAA TIHLNKLERE EHLVSAFQYF DKDGSGYITI DELQQSCIEH GMTDVFLEDI
501: IKEVDQDNDG RIDYEEFVAM MQKGNAGVGR RTMKNSLNIS MRDV
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)