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AT2G16370.1
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
cytosol 1.000
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : thymidylate synthase 1
Curator
Summary (TAIR10)
Encodes a bifunctional dihydrofolate reductase - thymidylate synthase gene. This is unique in Arabidopsis and protozoa. Other organisms have independent genes for this function.
Computational
Description (TAIR10)
thymidylate synthase 1 (THY-1); CONTAINS InterPro DOMAIN/s: Thymidylate synthase, active site (InterPro:IPR020940), Dihydrofolate reductase domain (InterPro:IPR001796), Dihydrofolate reductase conserved site (InterPro:IPR017925), Bifunctional dihydrofolate reductase/thymidylate synthase (InterPro:IPR012262), Thymidylate synthase (InterPro:IPR000398); BEST Arabidopsis thaliana protein match is: thymidylate synthase 2 (TAIR:AT4G34570.1); Has 13474 Blast hits to 13433 proteins in 2607 species: Archae - 76; Bacteria - 8708; Metazoa - 513; Fungi - 424; Plants - 92; Viruses - 253; Other Eukaryotes - 3408 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT2G16370-MONOMERBioGrid:1492EC:1.5.1.3EC:2.1.1.45
eggNOG:COG0207eggNOG:COG0262eggNOG:ENOG410JUW5eggNOG:KOG0673
eggNOG:KOG1324EMBL:AC007047EMBL:AY063968EMBL:AY114032
EMBL:CP002685EMBL:L08593EnsemblPlants:AT2G16370EnsemblPlants:AT2G16370.1
entrez:816134Gene3D:3.30.572.10Gene3D:3.40.430.10GeneID:816134
Genevisible:Q05762GO:GO:0004146GO:GO:0004799GO:GO:0005829
GO:GO:0006231GO:GO:0006545GO:GO:0006730GO:GO:0009257
Gramene:AT2G16370.1gramene_pathway:1.5.1.3gramene_pathway:2.1.1.45gramene_pathway:PWY-3742
gramene_pathway:PWY-3841gramene_pathway:PWY0-166HAMAP:MF_00008hmmpanther:PTHR11548
hmmpanther:PTHR11548:SF2HOGENOM:HOG000257901InParanoid:Q05762IntAct:Q05762
InterPro:IPR000398InterPro:IPR001796InterPro:IPR012262InterPro:IPR017925
InterPro:IPR020940InterPro:IPR023451InterPro:IPR024072iPTMnet:Q05762
KEGG:00240+2.1.1.45KEGG:00670+1.5.1.3KEGG:00670+1.5.1.3+2.1.1.45KEGG:00670+2.1.1.45
KEGG:00790+1.5.1.3KEGG:ath:AT2G16370KO:K13998OMA:NPVKKDI
PaxDb:Q05762Pfam:PF00186Pfam:PF00303Pfam:Q05762
Pfscan:PS51330PhylomeDB:Q05762PIR:E84539PIRSF:PIRSF000389
PRIDE:Q05762PRINTS:PR00108PRO:PR:Q05762PROSITE:PS00075
PROSITE:PS00091PROSITE:PS51330ProteinModelPortal:Q05762Proteomes:UP000006548
Reactome:R-ATH-113510Reactome:R-ATH-500753Reactome:R-ATH-69205RefSeq:NP_179230.1
scanprosite:PS00075scanprosite:PS00091SMR:Q05762STRING:3702.AT2G16370.1
SUPFAM:SSF53597SUPFAM:SSF55831TAIR:AT2G16370tair10-symbols:THY-1
TIGRfam:TIGR03284TIGRFAMs:TIGR03284UniGene:At.27124UniPathway:UPA00077
unipathway:UPA00575UniProt:Q05762
Coordinates (TAIR10) chr2:-:7082038..7084333
Molecular Weight (calculated) 58146.60 Da
IEP (calculated) 5.65
GRAVY (calculated) -0.20
Length 519 amino acids
Sequence (TAIR10)
(BLAST)
001: MATTTLNDSV TTTLASEPQR TYQVVVAATK EMGIGKDGKL PWNLPTDLKF FKDITLTTSD SSKKNAVVMG RKTWESIPIK YRPLSGRLNV VLTRSGGFDI
101: ANTENVVTCS SVDSALDLLA APPYCLSIER VFVIGGGDIL REALNRPSCD AIHLTEIDTS VDCDTFIPAI DTSVYQPWSS SFPVTENGLR FCFTTFVRVK
201: SSADESSDES NGSQSLQFDG KKFLFLPKMV FDQHEEFLYL NMVEDIISNG NVKNDRTGTG TLSKFGCQMK FNLRRSFPLL TTKRVFWRGV VEELLWFISG
301: STNAKVLQEK GIHIWDGNAS REYLDGIGLT EREEGDLGPV YGFQWRHFGA KYTDMHADYT GQGFDQLVDV IDKIKNNPDD RRIIMSAWNP SDLKLMALPP
401: CHMFAQFYVA EGELSCQMYQ RSADMGLGVP FNIASYSLLT CMLAHVCDLV PGDFIHVLGD AHVYKTHVRP LQEQLLNLPK PFPVMKINPE KKQIDSFVAS
501: DFDLTGYDPH KKIEMKMAV
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)