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AT2G05710.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
mitochondrion 1.000
ASURE: mitochondrion
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
FP Images

Arabidopsis cell culture (mitochondrial marker)

At2g05710-GFP
(full-length)
mitochondrial marker-RFPoverlay

Images by Sandra Tanz

Arabidopsis cell culture (plastidal marker)

At2g05710-GFP
(full-length)
plastidal marker-RFPoverlay

Images by Sandra Tanz
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : aconitase 3
Curator
Summary (TAIR10)
Encodes an aconitase that can catalyze the conversion of citrate to isocitrate through a cis-aconitate intermediate, indicating that it may participate in the TCA cycle and other primary metabolic pathways. The protein is believed to accumulate in the mitochondria and the cytosol. It affects CSD2 (At2g28190 - a superoxide dismutase) transcript levels and may play a role in the response to oxidative stress. One member of the family (ACO1 - At35830) was shown to specifically bind to the 5' UTR of CSD2 in vitro. ACO3 is tyrosine-phosphorylated and its phosphorylation state is modulated in response to ABA in Arabidopsis thaliana seeds.
Computational
Description (TAIR10)
aconitase 3 (ACO3); FUNCTIONS IN: aconitate hydratase activity, copper ion binding, ATP binding; INVOLVED IN: in 6 processes; LOCATED IN: cytosol, mitochondrion, cell wall, plasma membrane, chloroplast; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha (InterPro:IPR001030), Aconitase family, 4Fe-4S cluster binding site (InterPro:IPR018136), Aconitase A/isopropylmalate dehydratase small subunit, swivel (InterPro:IPR000573), Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2 (InterPro:IPR015932), Aconitase/Iron regulatory protein 2/2-methylisocitrate dehydratase (InterPro:IPR015934), Aconitase-like core (InterPro:IPR015937), Aconitase/3-isopropylmalate dehydratase, swivel (InterPro:IPR015928), Aconitase/iron regulatory protein 2 (InterPro:IPR006249), Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 (InterPro:IPR015931); BEST Arabidopsis thaliana protein match is: aconitase 1 (TAIR:AT4G35830.1); Has 20552 Blast hits to 20369 proteins in 2575 species: Archae - 558; Bacteria - 10777; Metazoa - 503; Fungi - 660; Plants - 232; Viruses - 0; Other Eukaryotes - 7822 (source: NCBI BLink).
Protein Annotations
BioGrid:519EC:4.2.1.3eggNOG:COG1048eggNOG:KOG0452EMBL:AC007170EMBL:AY136414EMBL:BT008809
EMBL:CP002685EnsemblPlants:AT2G05710EnsemblPlants:AT2G05710.1entrez:815120Gene3D:3.20.19.10Gene3D:3.30.499.10Gene3D:3.40.1060.10
GeneID:815120Genevisible:Q9SIB9GO:GO:0003994GO:GO:0005507GO:GO:0005524GO:GO:0005618GO:GO:0005739
GO:GO:0005774GO:GO:0005829GO:GO:0006097GO:GO:0006099GO:GO:0006101GO:GO:0006102GO:GO:0006979
GO:GO:0009507GO:GO:0009570GO:GO:0009651GO:GO:0009737GO:GO:0046686GO:GO:0051539Gramene:AT2G05710.1
gramene_pathway:4.2.1.3gramene_pathway:GLYOXYLATE-BYPASSgramene_pathway:PWY-5690gramene_pathway:PWY-6549gramene_pathway:PWYQT-4481hmmpanther:PTHR11670hmmpanther:PTHR11670:SF37
HOGENOM:HOG000025704InParanoid:Q9SIB9IntAct:Q9SIB9InterPro:IPR000573InterPro:IPR001030InterPro:IPR006249InterPro:IPR015928
InterPro:IPR015931InterPro:IPR015932InterPro:IPR015937InterPro:IPR018136iPTMnet:Q9SIB9KEGG:00020+4.2.1.3KEGG:00290+4.2.1.33
KEGG:00630+4.2.1.3KEGG:00720+4.2.1.3KEGG:ath:AT2G05710KO:K01681OMA:LRNCDGRPANTHER:PTHR11670PaxDb:Q9SIB9
Pfam:PF00330Pfam:PF00694Pfam:Q9SIB9PhylomeDB:Q9SIB9PIR:B84471PRIDE:Q9SIB9PRINTS:PR00415
PRO:PR:Q9SIB9PROSITE:PS00450PROSITE:PS01244ProteinModelPortal:Q9SIB9Proteomes:UP000006548RefSeq:NP_178634.2scanprosite:PS00450
scanprosite:PS01244SMR:Q9SIB9STRING:3702.AT2G05710.1SUPFAM:SSF52016SUPFAM:SSF53732TAIR:AT2G05710tair10-symbols:ACO3
TIGRfam:TIGR01341TIGRFAMs:TIGR01341UniGene:At.26759UniGene:At.67769unipathway:UPA00048UniPathway:UPA00223UniProt:Q9SIB9
Coordinates (TAIR10) chr2:+:2141591..2146350
Molecular Weight (calculated) 108207.00 Da
IEP (calculated) 7.17
GRAVY (calculated) -0.18
Length 990 amino acids
Sequence (TAIR10)
(BLAST)
001: MYLTASSSAS SSIIRAASSR SSSLFSFRSV LSPSVSSTSP SSLLARRSFG TISPAFRRWS HSFHSKPSPF RFTSQIRAVS PVLDRLQRTF SSMASEHPFK
101: GIFTTLPKPG GGEFGKFYSL PALNDPRVDK LPYSIRILLE SAIRNCDNFQ VTKEDVEKII DWEKTSPKQV EIPFKPARVL LQDFTGVPAV VDLACMRDAM
201: NKLGSDSNKI NPLVPVDLVI DHSVQVDVAR SENAVQANME LEFQRNKERF AFLKWGSTAF QNMLVVPPGS GIVHQVNLEY LGRVVFNTKG LLYPDSVVGT
301: DSHTTMIDGL GVAGWGVGGI EAEATMLGQP MSMVLPGVVG FKLAGKMRNG VTATDLVLTV TQMLRKHGVV GKFVEFYGNG MSGLSLADRA TIANMSPEYG
401: ATMGFFPVDH VTLQYLKLTG RSDETVAMIE AYLRANNMFV DYNEPQQDRV YSSYLELNLD DVEPCISGPK RPHDRVTLKE MKADWHSCLD SKVGFKGFAI
501: PKEAQEKVVN FSFDGQPAEL KHGSVVIAAI TSCTNTSNPS VMLGAGLVAK KACDLGLQVK PWIKTSLAPG SGVVTKYLLK SGLQEYLNEQ GFNIVGYGCT
601: TCIGNSGEIN ESVGAAITEN DIVAAAVLSG NRNFEGRVHP LTRANYLASP PLVVAYALAG TVNIDFETEP IGKGKNGKDV FLRDIWPTTE EIAEVVQSSV
701: LPDMFRATYE SITKGNPMWN KLSVPENTLY SWDPNSTYIH EPPYFKDMTM DPPGPHNVKD AYCLLNFGDS ITTDHISPAG NIQKDSPAAK FLMERGVDRK
801: DFNSYGSRRG NDEIMARGTF ANIRIVNKLM NGEVGPKTVH IPSGEKLSVF DAAMRYKSSG EDTIILAGAE YGSGSSRDWA AKGPMLQGVK AVIAKSFERI
901: HRSNLVGMGI IPLCFKSGED ADTLGLTGHE RYTIHLPTDI SEIRPGQDVT VTTDNGKSFT CTVRFDTEVE LAYFNHGGIL PYVIRNLSKQ
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)