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AT1G76490.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
endoplasmic reticulum 1.000
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : hydroxy methylglutaryl CoA reductase 1
Curator
Summary (TAIR10)
Encodes a 3-hydroxy-3-methylglutaryl coenzyme A reductase, which is involved in melavonate biosynthesis and performs the first committed step in isoprenoid biosynthesis. Expression is activated in dark in leaf tissue but not controlled by light in the root (confine
Computational
Description (TAIR10)
hydroxy methylglutaryl CoA reductase 1 (HMG1); CONTAINS InterPro DOMAIN/s: Hydroxymethylglutaryl-CoA reductase, class I, catalytic (InterPro:IPR004554), Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding (InterPro:IPR009029), Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding (InterPro:IPR009023), Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic (InterPro:IPR002202); BEST Arabidopsis thaliana protein match is: 3-hydroxy-3-methylglutaryl-CoA reductase 2 (TAIR:AT2G17370.1); Has 2212 Blast hits to 2210 proteins in 935 species: Archae - 202; Bacteria - 1018; Metazoa - 225; Fungi - 225; Plants - 266; Viruses - 1; Other Eukaryotes - 275 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT1G76490-MONOMERBioCyc:MetaCyc:AT1G76490-MONOMEREC:1.1.1.34eggNOG:COG1257eggNOG:KOG2480EMBL:AC015450EMBL:CP002684
EMBL:S80135EMBL:X15032EnsemblPlants:AT1G76490EnsemblPlants:AT1G76490.1entrez:843982ExpressionAtlas:P14891ExpressionAtlas:Q38812
GeneID:843982GO:GO:0004420GO:GO:0005778GO:GO:0005783GO:GO:0005789GO:GO:0008299GO:GO:0015936
GO:GO:0016126GO:GO:0042282GO:GO:0060964gramene_pathway:1.1.1.34gramene_pathway:PWY-922gramene_plant_reactome:1119615gramene_plant_reactome:6875859
hmmpanther:PTHR10572hmmpanther:PTHR10572:SF9InParanoid:P14891InterPro:IPR002202InterPro:IPR009023InterPro:IPR009029InterPro:IPR023076
KEGG:00900+1.1.1.34KEGG:ath:AT1G76490KO:K00021PaxDb:C0Z3D4PaxDb:P14891PaxDb:Q38812Pfam:P14891
Pfam:PF00368Pfscan:PS50065PhylomeDB:P14891PRO:PR:P14891PROSITE:PS00318Proteomes:UP000006548Reactome:R-ATH-191273
scanprosite:PS00066scanprosite:PS00318scanprosite:PS01192STRING:3702.AT1G76490.1TAIR:AT1G76490tair10-symbols:AtHMGR1tair10-symbols:HMG1
tair10-symbols:HMGR1TIGRfam:TIGR00533TMHMM:TMhelixUniPathway:UPA00058UniProt:C0Z3D4UniProt:P14891UniProt:Q38812
Coordinates (TAIR10) chr1:+:28695801..28698206
Molecular Weight (calculated) 69284.20 Da
IEP (calculated) 7.59
GRAVY (calculated) -0.01
Length 642 amino acids
Sequence (TAIR10)
(BLAST)
001: MKKKQAGPQQ TCEFVSYKTL LISPSHLSRH LTTSLLSPLS PPWRDYSFPP MDLRRRPPKP PVTNNNNSNG SFRSYQPRTS DDDHRRRATT IAPPPKASDA
101: LPLPLYLTNA VFFTLFFSVA YYLLHRWRDK IRYNTPLHVV TITELGAIIA LIASFIYLLG FFGIDFVQSF ISRASGDAWD LADTIDDDDH RLVTCSPPTP
201: IVSVAKLPNP EPIVTESLPE EDEEIVKSVI DGVIPSYSLE SRLGDCKRAA SIRREALQRV TGRSIEGLPL DGFDYESILG QCCEMPVGYI QIPVGIAGPL
301: LLDGYEYSVP MATTEGCLVA STNRGCKAMF ISGGATSTVL KDGMTRAPVV RFASARRASE LKFFLENPEN FDTLAVVFNR SSRFARLQSV KCTIAGKNAY
401: VRFCCSTGDA MGMNMVSKGV QNVLEYLTDD FPDMDVIGIS GNFCSDKKPA AVNWIEGRGK SVVCEAVIRG EIVNKVLKTS VAALVELNML KNLAGSAVAG
501: SLGGFNAHAS NIVSAVFIAT GQDPAQNVES SQCITMMEAI NDGKDIHISV TMPSIEVGTV GGGTQLASQS ACLNLLGVKG ASTESPGMNA RRLATIVAGA
601: VLAGELSLMS AIAAGQLVRS HMKYNRSSRD ISGATTTTTT TT
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)