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AT1G74040.1
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
plastid 1.000
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : 2-isopropylmalate synthase 1
Curator
Summary (TAIR10)
Encodes an active Arabidopsis isopropylmalate synthase IPMS2. Involved in leucine biosynthesis. Do not participate in the chain elongation of glucosinolates. Expressed constitutively throughout the plant. Loss of IPMS2 can be compensated by a second isopropylmalate synthase gene IPMS1 (At1g18500).
Computational
Description (TAIR10)
2-isopropylmalate synthase 1 (IMS1); FUNCTIONS IN: 2-isopropylmalate synthase activity; INVOLVED IN: leucine biosynthetic process; LOCATED IN: chloroplast, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), Alpha-isopropylmalate/homocitrate synthase, conserved site (InterPro:IPR002034), 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain (InterPro:IPR013709), Pyruvate carboxyltransferase (InterPro:IPR000891), Bacterial 2-isopropylmalate synthase (InterPro:IPR005671); BEST Arabidopsis thaliana protein match is: methylthioalkylmalate synthase-like 4 (TAIR:AT1G18500.1); Has 16891 Blast hits to 16883 proteins in 2449 species: Archae - 499; Bacteria - 8886; Metazoa - 193; Fungi - 474; Plants - 279; Viruses - 0; Other Eukaryotes - 6560 (source: NCBI BLink).
Protein Annotations
BioGrid:28961BRENDA:2.3.3.13EC:2.3.3.13eggNOG:COG0119
eggNOG:KOG2367EMBL:AC016662EMBL:AF327647EMBL:AK118569
EMBL:AY057659EMBL:BT000815EMBL:CP002684EnsemblPlants:AT1G74040
EnsemblPlants:AT1G74040.1entrez:843742Gene3D:3.20.20.70GeneID:843742
Genevisible:Q9C550GO:GO:0003852GO:GO:0009098GO:GO:0009507
GO:GO:0009941GO:GO:0016829Gramene:AT1G74040.1gramene_plant_reactome:1119540
gramene_plant_reactome:6875186HAMAP:MF_01025hmmpanther:PTHR10277hmmpanther:PTHR10277:SF42
HOGENOM:HOG000046859InParanoid:Q9C550InterPro:IPR000891InterPro:IPR002034
InterPro:IPR005671InterPro:IPR013709InterPro:IPR013785KEGG:00290+2.3.3.13
KEGG:00620+2.3.3.13KEGG:ath:AT1G74040KO:K01649OMA:DHALECD
PaxDb:Q9C550Pfam:PF00682Pfam:PF08502Pfam:Q9C550
Pfscan:PS50991PhylomeDB:Q9C550PIR:C96768PRIDE:Q9C550
PRO:PR:Q9C550PROSITE:PS00815PROSITE:PS50991ProteinModelPortal:Q9C550
Proteomes:UP000006548RefSeq:NP_177544.1scanprosite:PS00815SMART:SM00917
SMR:Q9C550STRING:3702.AT1G74040.1SUPFAM:0043727SUPFAM:SSF110921
SUPFAM:SSF51569TAIR:AT1G74040tair10-symbols:IMS1tair10-symbols:IPMS2
tair10-symbols:MAML-3TIGRfam:TIGR00973TIGRFAMs:TIGR00973UniGene:At.18219
UniGene:At.52503UniPathway:UPA00048UniProt:Q9C550
Coordinates (TAIR10) chr1:+:27842258..27845566
Molecular Weight (calculated) 68140.10 Da
IEP (calculated) 6.32
GRAVY (calculated) -0.21
Length 631 amino acids
Sequence (TAIR10)
(BLAST)
001: MESSILKSPN LSSPSFGVPS IPALSSSSTS PFSSLHLRSQ NHRTISLTTA GKFRVSYSLS ASSPLPPHAP RRRPNYIPNR ISDPNYVRIF DTTLRDGEQS
101: PGATLTSKEK LDIARQLAKL GVDIIEAGFP AASKDDFEAV KTIAETVGNT VDENGYVPVI CGLSRCNKKD IETAWEAVKY AKRPRIHTFI ATSDIHLKYK
201: LKKSKEEVIE IARNMVRFAR SLGCEDVEFS PEDAGRSERE YLYEILGEVI KAGATTLNIP DTVGITLPSE FGQLIADIKA NTPGIQNVII STHCQNDLGL
301: STANTLSGAH SGARQVEVTI NGIGERAGNA SLEEVVMAIK CRGDHVLGGL FTGIDTRHIV MTSKMVEEYT GMQTQPHKAI VGANAFAHES GIHQDGMLKH
401: KGTYEIMSPE EIGLERSNDA GIVLGKLSGR HALKDRLNEL GYVLDDGQLS NLFWRFKAVA EQKKRVTDAD LIALVSDEVF QPEAVWKLLD MQITCGTLGL
501: STSTVKLADS DGKEHVACSV GTGPVDAAYK AVDLIVKEPA TLLEYSMNAV TEGIDAIATT RVLIRGDNNY SSTNAVTGES VERTFSGTGA GMDIVVSSVK
601: AYVGALNKML GFKEHTSTLS KTPLETNEVP A
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)