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AT1G60490.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
cytosol 0.986
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:23667806 (2013): plastid plastid thylakoid
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : vacuolar protein sorting 34
Curator
Summary (TAIR10)
Encodes a phosphatidylinositol 3-kinase that is expressed in most plant tissues. Defects in VPS34 affect a number of cellular processes. Loss of function mutations are not transmitted through the male gametophyte due to defects in microgametogenesis therefore it is difficult to assess the effects of loss of VPS34 function in the whole plant. Involved in salt-stress responses.
Computational
Description (TAIR10)
vacuolar protein sorting 34 (VPS34); FUNCTIONS IN: 1-phosphatidylinositol-3-kinase activity, inositol or phosphatidylinositol kinase activity, binding, phosphotransferase activity, alcohol group as acceptor; INVOLVED IN: oxygen and reactive oxygen species metabolic process, response to salt stress, endocytosis, N-terminal protein myristoylation, microgametogenesis; LOCATED IN: phosphoinositide 3-kinase complex; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Phosphatidylinositol 3-/4-kinase, catalytic (InterPro:IPR000403), Phosphoinositide 3-kinase, accessory (PIK) domain (InterPro:IPR001263), Phosphoinositide 3-kinase, C2 (InterPro:IPR002420), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), Protein kinase-like domain (InterPro:IPR011009), Phosphatidylinositol Kinase (InterPro:IPR015433), Phosphatidylinositol 3-kinase, Vps34 type (InterPro:IPR008290), Armadillo-type fold (InterPro:IPR016024), Phosphatidylinositol 3/4-kinase, conserved site (InterPro:IPR018936); BEST Arabidopsis thaliana protein match is: Phosphatidylinositol 3- and 4-kinase family protein (TAIR:AT1G49340.1); Has 3550 Blast hits to 3392 proteins in 278 species: Archae - 0; Bacteria - 0; Metazoa - 1514; Fungi - 819; Plants - 335; Viruses - 4; Other Eukaryotes - 878 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT1G60490-MONOMERBioGrid:27568BRENDA:2.7.1.137EC:2.7.1.137eggNOG:COG5032eggNOG:KOG0906EMBL:AC002292
EMBL:BT000878EMBL:CP002684EMBL:U10669EnsemblPlants:AT1G60490EnsemblPlants:AT1G60490.1entrez:842344Gene3D:1.10.1070.11
Gene3D:1.25.40.70Gene3D:2.60.40.150GeneID:842344Genevisible:P42339GO:GO:0000045GO:GO:0000407GO:GO:0005524
GO:GO:0005768GO:GO:0005777GO:GO:0006468GO:GO:0006897GO:GO:0009651GO:GO:0016197GO:GO:0016303
GO:GO:0030242GO:GO:0034271GO:GO:0034272GO:GO:0036092GO:GO:0048015GO:GO:0055046GO:GO:0072593
Gramene:AT1G60490.1hmmpanther:PTHR10048hmmpanther:PTHR10048:SF62HOGENOM:HOG000174003InParanoid:P42339IntAct:P42339InterPro:IPR000008
InterPro:IPR000403InterPro:IPR001263InterPro:IPR002420InterPro:IPR011009InterPro:IPR015433InterPro:IPR016024InterPro:IPR018936
KEGG:ath:AT1G60490KO:K00914OMA:LAITVWDPANTHER:PTHR10048PaxDb:P42339Pfam:P42339Pfam:PF00454
Pfam:PF00613Pfam:PF00792Pfscan:PS50290Pfscan:PS51545Pfscan:PS51547PhylomeDB:P42339PIR:B96630
PRIDE:P42339PRO:PR:P42339PROSITE:PS00915PROSITE:PS00916PROSITE:PS50290PROSITE:PS51545PROSITE:PS51547
ProteinModelPortal:P42339Proteomes:UP000006548Reactome:R-ATH-1632852Reactome:R-ATH-1660514Reactome:R-ATH-1660516Reactome:R-ATH-1660517Reactome:R-ATH-5668599
RefSeq:NP_176251.1scanprosite:PS00915scanprosite:PS00916SMART:SM00142SMART:SM00145SMART:SM00146SMR:P42339
STRING:3702.AT1G60490.1SUPFAM:SSF48371SUPFAM:SSF49562SUPFAM:SSF56112TAIR:AT1G60490tair10-symbols:ATVPS34tair10-symbols:PI3K
tair10-symbols:VPS34UniGene:At.1545UniProt:P42339
Coordinates (TAIR10) chr1:-:22285792..22290190
Molecular Weight (calculated) 93332.70 Da
IEP (calculated) 6.75
GRAVY (calculated) -0.26
Length 814 amino acids
Sequence (TAIR10)
(BLAST)
001: MGANEFRFFL SCDINSPVTF RIEKLDGNLP VKKSSDSGVV SIAEEKKPEL YIECALYIDG APFGLPMRTR LKTTGPPYCW NELITLSSKY RDLTAHSQLA
101: ITVWDVSCGK TEGLIGGATV LLFNSKMQMK SGKQKLRLWQ GKEADGSFPT STPGKVPRHE RGELERLEKL MNKYERGQIQ SIDWLDRLML KSLDTIKEQE
201: STKHGSSHLF VVIDFCSFEH RVVFQESGAN LFITAPIGST NEFVTVWDTE LGKTNPSENK QLKLARSLDR GIIDRDLKPS NIERKSIQRV LKYPPTRTLS
301: GDERQLLWKF RFSLMSEKRA LTKFLRCVEW SDVQEAKQAI QLMYKWEMID VCDALELLSP LFESEEVRAY AVSVLERADD EELQCYLLQL VQALRFERSD
401: RSCLSQFLVQ RALQNIELAS FLRWYVAVEL HDHVYAKRFY STYELLEENI IKLPPGVNGE DGYQLWQSLV RQTELTAQLC SITREVRNVR GNTQKKIEKL
501: RQLLGGLLSE LTYFEEPIRS PLTPNVLIKG IVAGESSLFK SALHPLRLTF RTPEEGGSCK LIFKKGDDLR QDQLVVQMVW LMDRLLKLEN LDLCLTPYKV
601: LATGHDEGML EFIPSRSLAQ ILSEHRSITS YLQKFHPDEH APFGITATCL DTFIKSCAGY SVITYILGIG DRHLDNLLLT DDGRLFHVDF AFILGRDPKP
701: FPPPMKLCKE MVEAMGGAES QYYTRFKSYC CEAYNILRKS SNLILNLFHL MAGSTIPDIA SDPEKGILKL QEKFRLDMDD EACIHFFQDL INESVSALFP
801: QMVETIHRWA QYWR
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)