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AT1G29690.1
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
plasma membrane 1.000
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:28865150 (2017): extracellular region plant-type cell wall
  • PMID:26781341 (2016): plasma membrane
  • PMID:15574830 (2004): plasma membrane
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : MAC/Perforin domain-containing protein
Curator
Summary (TAIR10)
Encodes a protein containing a domain with significant homology to the MACPF (membrane attack complex and perforin) domain of complements and perforin proteins that are involved in innate immunity in animals. Transgenic <i>cad1-1</i> mutant plants show lesions seen in the hypersensitive response, as well as a spontaneous activation of expression of pathogenesis-related genes and leading to a 32-fold increase in salicylic acid (SA). CAD1 is postulated to act as a negative regulator controlling SA-mediated pathway of programmed cell death in plant immunity.
Computational
Description (TAIR10)
constitutively activated cell death 1 (CAD1); CONTAINS InterPro DOMAIN/s: Membrane attack complex component/perforin (MACPF) domain (InterPro:IPR020864); BEST Arabidopsis thaliana protein match is: MAC/Perforin domain-containing protein (TAIR:AT4G24290.2); Has 226 Blast hits to 225 proteins in 30 species: Archae - 0; Bacteria - 6; Metazoa - 14; Fungi - 0; Plants - 200; Viruses - 0; Other Eukaryotes - 6 (source: NCBI BLink).
Protein Annotations
BioGrid:25081eggNOG:ENOG410JR2DeggNOG:ENOG410XRQREMBL:AC068667
EMBL:AY054177EMBL:AY074857EMBL:BT030337EMBL:CP002684
EnsemblPlants:AT1G29690EnsemblPlants:AT1G29690.1entrez:839846GeneID:839846
Genevisible:Q9C7N2GO:GO:0006955GO:GO:0008219GO:GO:0009626
GO:GO:0010337Gramene:AT1G29690.1hmmpanther:PTHR33199hmmpanther:PTHR33199:SF3
HOGENOM:HOG000238669InParanoid:Q9C7N2InterPro:IPR020864iPTMnet:Q9C7N2
KEGG:ath:AT1G29690OMA:RKEPVCSPaxDb:Q9C7N2Pfam:PF01823
Pfam:Q9C7N2Pfscan:PS51412PhylomeDB:Q9C7N2PIR:C86420
PRIDE:Q9C7N2PRO:PR:Q9C7N2PROSITE:PS51412ProteinModelPortal:Q9C7N2
Proteomes:UP000006548RefSeq:NP_564333.1SMART:SM00457SMR:Q9C7N2
STRING:3702.AT1G29690.1TAIR:AT1G29690tair10-symbols:CAD1TCDB:1.C.39.11.3
UniGene:At.17864UniGene:At.67331UniProt:Q9C7N2
Coordinates (TAIR10) chr1:-:10379310..10381861
Molecular Weight (calculated) 62226.40 Da
IEP (calculated) 8.17
GRAVY (calculated) -0.27
Length 561 amino acids
Sequence (TAIR10)
(BLAST)
001: MENRKGGNFS VPSSEALTTT LRNAIQALGR GFDVTSDVRL LYCKGAPGSR LVRIEEGQNR DLELSHGFLL PNVPADIDCS RGNSGTQRIS VCSFHEMAEE
101: FNVRSGVKGN IPLGCFNAMF NYTGSWQVDA ASTKSLALVG YFIPLYDVKL AKLTLVLHNE IRRAVPSSWD PASLASFIEN YGTHIVTSVT IGGRDVVYIR
201: QHQSSPLPVS EIENYVNDMI KHRFHEAESQ SITGPLKYKD KDITVIFRRR GGDDLEQSHA RWAETVPAAP DIINMTFTPI VSLLEGVPGL RHLTRAIELY
301: LEYKPPIEDL QYFLDYQIAR AWAPEQSNLQ RKEPVCSSLQ FSLMGPKLFI SADQVTVGRK PVTGLRLSLE GSKQNRLSIH LQHLVSLPKI LQPHWDSHVP
401: IGAPKWQGPE EQDSRWFEPI KWKNFSHVST SPIEHTETHI GDLSGVHIVT GAQLGVWDFG SKNVLHLKLL FSKVPGCTIR RSVWDHTPVA SSGRLEPGGP
501: STSSSTEEVS GQSGKLAKIV DSSEMLKGPQ DLPGHWLVTG AKLGVEKGKI VLRVKYSLLN Y
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)