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AT1G11310.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
plasma membrane 1.000
ASURE: plasma membrane
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:25402197 (2015): plastid plastid thylakoid plastid thylakoid membrane
  • PMID:22430844 (2012): Golgi
  • PMID:21826108 (2012): Golgi trans-Golgi network multivesicular body
  • PMID:17317660 (2007): plasma membrane
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : Seven transmembrane MLO family protein
Curator
Summary (TAIR10)
A member of a large family of seven-transmembrane domain proteins specific to plants, homologs of the barley mildew resistance locus o (MLO) protein. The Arabidopsis genome contains 15 genes encoding MLO proteins, with localization in plasma membrane. Phylogenetic analysis revealed four clades of closely-related AtMLO genes. ATMLO2 belongs to the clade IV, with AtMLO3, AtMLO6 and AtMLO12. The gene is expressed during early seedling growth, in roots, in vascular system of cotyledons and young leaves,and in fruit abscission zone; it was not expressed in anthers and pollen, as shown by GUS activity patterns. The expression of several phylogenetically closely-related AtMLO genes showed similar or overlapping tissue specificity and analogous responsiveness to external stimuli, suggesting functional redundancy, co-function, or antagonistic function(s). mlo resistance in A. thaliana does not involve the signaling molecules ethylene, jasmonic acid or salicylic acid, but requires a syntaxin, glycosyl hydrolase and ABC transporter.
Computational
Description (TAIR10)
MILDEW RESISTANCE LOCUS O 2 (MLO2); FUNCTIONS IN: calmodulin binding; INVOLVED IN: defense response to fungus, incompatible interaction, cell death, response to fungus, negative regulation of defense response, defense response; LOCATED IN: plasma membrane; EXPRESSED IN: 29 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Mlo-related protein (InterPro:IPR004326); BEST Arabidopsis thaliana protein match is: Seven transmembrane MLO family protein (TAIR:AT1G61560.1); Has 559 Blast hits to 538 proteins in 60 species: Archae - 0; Bacteria - 0; Metazoa - 1; Fungi - 2; Plants - 551; Viruses - 0; Other Eukaryotes - 5 (source: NCBI BLink).
Protein Annotations
BioGrid:22913eggNOG:ENOG410IHFAeggNOG:ENOG410ZUVBEMBL:AC007259EMBL:AF369563EMBL:AY086586EMBL:CP002684
EnsemblPlants:AT1G11310EnsemblPlants:AT1G11310.1entrez:837673ExpressionAtlas:Q9SXB6GeneID:837673Genevisible:Q9SXB6GO:GO:0005794
GO:GO:0005886GO:GO:0009506GO:GO:0009620GO:GO:0009817GO:GO:0016021GO:GO:0031348hmmpanther:PTHR31942
hmmpanther:PTHR31942:SF29HOGENOM:HOG000239166InParanoid:Q9SXB6InterPro:IPR004326iPTMnet:Q9SXB6ncoils:CoilOMA:PIRTSKS
PaxDb:Q9SXB6Pfam:PF03094Pfam:Q9SXB6PhylomeDB:Q9SXB6PIR:B86247PRIDE:Q9SXB6PRO:PR:Q9SXB6
Proteomes:UP000006548RefSeq:NP_172598.1STRING:3702.AT1G11310.1TAIR:AT1G11310tair10-symbols:ATMLO2tair10-symbols:MLO2tair10-symbols:PMR2
TMHMM:TMhelixUniGene:At.24513UniProt:Q0WWA7UniProt:Q9SXB6
Coordinates (TAIR10) chr1:-:3800899..3803870
Molecular Weight (calculated) 65547.30 Da
IEP (calculated) 9.85
GRAVY (calculated) -0.10
Length 573 amino acids
Sequence (TAIR10)
(BLAST)
001: MADQVKERTL EETSTWAVAV VCFVLLFISI VLEHSIHKIG TWFKKKHKQA LFEALEKVKA ELMLLGFISL LLTIGQTPIS NICISQKVAS TMHPCSAAEE
101: AKKYGKKDAG KKDDGDGDKP GRRLLLELAE SYIHRRSLAT KGYDKCAEKG KVAFVSAYGI HQLHIFIFVL AVVHVVYCIV TYAFGKIKMR TWKSWEEETK
201: TIEYQYSNDP ERFRFARDTS FGRRHLNFWS KTRVTLWIVC FFRQFFGSVT KVDYLALRHG FIMAHFAPGN ESRFDFRKYI QRSLEKDFKT VVEISPVIWF
301: VAVLFLLTNS YGLRSYLWLP FIPLVVILIV GTKLEVIITK LGLRIQEKGD VVRGAPVVQP GDDLFWFGKP RFILFLIHLV LFTNAFQLAF FAWSTYEFNL
401: NNCFHESTAD VVIRLVVGAV VQILCSYVTL PLYALVTQMG SKMKPTVFND RVATALKKWH HTAKNETKHG RHSGSNTPFS SRPTTPTHGS SPIHLLHNFN
501: NRSVENYPSS PSPRYSGHGH HEHQFWDPES QHQEAETSTH HSLAHESSEP VLASVELPPI RTSKSLRDFS FKK
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)