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AT1G04400.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
cytosol 0.500
nucleus 0.500
ASURE: cytosol,nucleus
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:24134884 (2013): cytoskeleton microtubules
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : cryptochrome 2
Curator
Summary (TAIR10)
Blue light receptor mediating blue-light regulated cotyledon expansion and flowering time. Positive regulator of the flowering-time gene CONSTANS. This gene possesses a light-induced CNT2 N-terminal homodimerisation domain.Involved in blue-light induced stomatal opening. Involved in triggering chromatin decondensation. An 80-residue motif (NC80) is sufficient to confer CRY2's physiological function. It is proposed that the PHR domain and the C-terminal tail of the unphosphorylated CRY2 form a "closed" conformation to suppress the NC80 motif in the absence of light. In response to blue light, the C-terminal tail of CRY2 is phosphorylated and electrostatically repelled from the surface of the PHR domain to form an "open" conformation, resulting in derepression of the NC80 motif and signal transduction to trigger photomorphogenic responses. Cry2 phosphorylation and degradation both occur in the nucleus.
Computational
Description (TAIR10)
cryptochrome 2 (CRY2); FUNCTIONS IN: protein homodimerization activity, blue light photoreceptor activity; INVOLVED IN: in 9 processes; LOCATED IN: nucleus, vacuole; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Rossmann-like alpha/beta/alpha sandwich fold (InterPro:IPR014729), Cryptochrome/DNA photolyase, class 1 conserved site, C-terminal (InterPro:IPR018394), DNA photolyase, N-terminal (InterPro:IPR006050), DNA photolyase, FAD-binding/Cryptochrome, C-terminal (InterPro:IPR005101), Cryptochrome, plant (InterPro:IPR014134), Cryptochrome/DNA photolyase, class 1 (InterPro:IPR002081); BEST Arabidopsis thaliana protein match is: cryptochrome 1 (TAIR:AT4G08920.1); Has 10129 Blast hits to 10113 proteins in 1516 species: Archae - 99; Bacteria - 3201; Metazoa - 386; Fungi - 148; Plants - 723; Viruses - 2; Other Eukaryotes - 5570 (source: NCBI BLink).
Protein Annotations
eggNOG:COG0415eggNOG:KOG0133EMBL:JF318406EMBL:JF318424EMBL:JF318438EMBL:JF318457EMBL:JF318462
EMBL:JF318479EMBL:JF318486EMBL:JF318493EMBL:JF318521EMBL:JF318526EMBL:JF318531EMBL:JF318544
EMBL:JF318577EnsemblPlants:AT1G04400EnsemblPlants:AT1G04400.1EnsemblPlants:AT1G04400.2entrez:839529ExpressionAtlas:G4WTR2Gene3D:3.40.50.620
GeneID:839529GO:GO:0005524GO:GO:0009882Gramene:AT1G04400.1Gramene:AT1G04400.2hmmpanther:PTHR11455hmmpanther:PTHR11455:SF24
InterPro:IPR002081InterPro:IPR005101InterPro:IPR006050InterPro:IPR014134InterPro:IPR014729InterPro:IPR018394KEGG:ath:AT1G04400
KO:K12119OMA:WGERYFRPfam:PF00875Pfam:PF03441Pfam:Q96524Pfscan:PS51645PhylomeDB:G4WTR2
PRINTS:PR00147PROSITE:PS00394PROSITE:PS00691PROSITE:PS51645RefSeq:NP_171935.1RefSeq:NP_849588.1scanprosite:PS00394
scanprosite:PS00691SMR:G4WTR2STRING:3702.AT1G04400.1SUPFAM:SSF48173SUPFAM:SSF52425tair10-symbols:AT-PHH1tair10-symbols:ATCRY2
tair10-symbols:CRY2tair10-symbols:FHAtair10-symbols:PHH1TIGRfam:TIGR02766TIGRFAMs:TIGR02766UniGene:At.21976UniProt:G4WTR2
UniProt:Q96524
Coordinates (TAIR10) chr1:-:1185719..1187901
Molecular Weight (calculated) 69460.60 Da
IEP (calculated) 5.83
GRAVY (calculated) -0.34
Length 612 amino acids
Sequence (TAIR10)
(BLAST)
001: MKMDKKTIVW FRRDLRIEDN PALAAAAHEG SVFPVFIWCP EEEGQFYPGR ASRWWMKQSL AHLSQSLKAL GSDLTLIKTH NTISAILDCI RVTGATKVVF
101: NHLYDPVSLV RDHTVKEKLV ERGISVQSYN GDLLYEPWEI YCEKGKPFTS FNSYWKKCLD MSIESVMLPP PWRLMPITAA AEAIWACSIE ELGLENEAEK
201: PSNALLTRAW SPGWSNADKL LNEFIEKQLI DYAKNSKKVV GNSTSLLSPY LHFGEISVRH VFQCARMKQI IWARDKNSEG EESADLFLRG IGLREYSRYI
301: CFNFPFTHEQ SLLSHLRFFP WDADVDKFKA WRQGRTGYPL VDAGMRELWA TGWMHNRIRV IVSSFAVKFL LLPWKWGMKY FWDTLLDADL ECDILGWQYI
401: SGSIPDGHEL DRLDNPALQG AKYDPEGEYI RQWLPELARL PTEWIHHPWD APLTVLKASG VELGTNYAKP IVDIDTAREL LAKAISRTRE AQIMIGAAPD
501: EIVADSFEAL GANTIKEPGL CPSVSSNDQQ VPSAVRYNGS KRVKPEEEEE RDMKKSRGFD ERELFSTAES SSSSSVFFVS QSCSLASEGK NLEGIQDSSD
601: QITTSLGKNG CK
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)