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AT5G19400.1
Subcellular Consensus
(Prediction and Experimental)
min: heatmap :max

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SUBAcon:
nucleus 1.000
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : Telomerase activating protein Est1
Curator
Summary (TAIR10)
Encodes SMG7, a protein that possesses an evolutionarily conserved EST1 domain and exhibits strong homology to human SMG6 (EST1A) and SMG7 (EST1C) proteins. SMG7 plays an evolutionarily conserved role in nonsense-mediated RNA decay (NMD). Required for exit from meiosis. Hypomorphic smg7 alleles render mutant plants sterile by causing an unusual cell-cycle arrest in anaphase II that is characterized by delayed chromosome decondensation and aberrant rearrangement of the meiotic spindle. Disruption of SMG7 causes embryonic lethality.
Computational
Description (TAIR10)
SMG7; CONTAINS InterPro DOMAIN/s: Telomerase activating protein Est1 (InterPro:IPR019458); BEST Arabidopsis thaliana protein match is: Telomerase activating protein Est1 (TAIR:AT1G28260.2); Has 648 Blast hits to 623 proteins in 143 species: Archae - 0; Bacteria - 0; Metazoa - 367; Fungi - 169; Plants - 90; Viruses - 0; Other Eukaryotes - 22 (source: NCBI BLink).
Protein Annotations
BioGrid:17336eggNOG:ENOG410XR9ZeggNOG:KOG2162EMBL:AF296837
EMBL:CP002688EMBL:EU126544EnsemblPlants:AT5G19400EnsemblPlants:AT5G19400.1
EnsemblPlants:AT5G19400.2EnsemblPlants:AT5G19400.3entrez:832060GeneID:832060
Genevisible:A9QM73GO:GO:0000184GO:GO:0000932GO:GO:0005634
GO:GO:0006952GO:GO:0007126GO:GO:0007275GO:GO:0040008
GO:GO:0090306Gramene:AT5G19400.1Gramene:AT5G19400.2Gramene:AT5G19400.3
hmmpanther:PTHR15696hmmpanther:PTHR15696:SF0InParanoid:A9QM73InterPro:IPR011990
InterPro:IPR018834InterPro:IPR019458iPTMnet:A9QM73KEGG:ath:AT5G19400
KO:K14409OMA:CCPDIASPaxDb:A9QM73Pfam:A9QM73
Pfam:PF10373Pfam:PF10374PhylomeDB:A9QM73PRIDE:A9QM73
PRO:PR:A9QM73ProteinModelPortal:A9QM73Proteomes:UP000006548Reactome:R-ATH-975957
RefSeq:NP_001190336.1RefSeq:NP_001190337.1RefSeq:NP_197441.3STRING:3702.AT5G19400.1
SUPFAM:SSF48452TAIR:AT5G19400tair10-symbols:SMG7UniGene:At.43842
UniProt:A9QM73
Coordinates (TAIR10) chr5:+:6540603..6544262
Molecular Weight (calculated) 117012.00 Da
IEP (calculated) 7.25
GRAVY (calculated) -0.41
Length 1059 amino acids
Sequence (TAIR10)
(BLAST)
0001: MMTLQMDKTT ASSSWERAKS IYDEIAELAN KRQKAGNPPD PNLLQLLREK YEAIILESHT FSEQHNIEIP LWQLHYKRIE YFRLHINRVL ASSTSTAAQN
0101: VKGPSKAEQI AQLKLQFRTF LSEATGFYHD MILKIRSKYG LPLGSFSEDQ QSQNLSDKDG KELAEVQKAL KSCHRCLIYL GDLARYKGMY AEGDSRSRQY
0201: ASASSYYLQA ASLWPASGNP HHQLAIVASY SRDEFVTTYR YFRSLAVEYP FPTARDNLIV AFDKNRQSYE KLFVPSKDSS KRLTGKGRGK GADISLKDAT
0301: LVAGPEKDKV TIANEMLKAF SIRFVHLNGI LFTRTSLETF FDVLASTSSS LREVISLGSA KELTLGIDTS DSALFIVRVV TMLIFSVHNS KKETEGQSYA
0401: EIVQRVEPAR NSLTASFELL GLVIEKCVQL GDPSSSYFLP GVLVFVEWLA CCPDIALGSD PDDRQTAVRN SFWNQFVVFF NQVLSLGPTF IDDVEDETCF
0501: SNMSLYDERE TENRLALWED YELRGFLPLL PAQTILNFSR KHSFGTEGPK EKKARIKRIF AAGKALTSVI KVDQNHVYFD SKKKKFLVGV KPADDFLDSH
0601: SSPPKACNAL QDNQVMIDHN SPIMQLDQQI YMGEEDDDDE VIVFKPLVTE KRKEASDQIY VPSGGFRKSD QVTTMGDFKA LSGSDVAFHE NQILQARGNA
0701: SIQVPASVGA NLLGPLQPST QSQAMHMQQV QTQVQVPASV GANLLGLLLT STQSQAMHMQ QVQTQAVNPQ PAQSLAASRL QPIQSQVAQP LPSRVVHFQQ
0801: TQAQVSHVSP AHSQSTSFGG GSKWSPEEAA SLASSLSGFA QLGNGHVMRN EMQGNHGVSY YPAHSLPVHQ SYNGNGMGGM PYSQSRTPEA VFPPKIDPVL
0901: SSGVVADGLG VQSSLAKKNP ISRAFRHLGP PPGFNSVPAK LQKEPAPGSE LSGNNHLPVD DYSWLDGYQA QSSRGVGLNS SLNYATSGKP EHLGSTGNGL
1001: NGPANFPFPG KQVPTSQVQA DFPYFQNPQK DNFVDKNHQS TQLPEQYQGQ STWSSRHFV
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)