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AT2G29630.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
plastid 1.000
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:27122571 (2016): mitochondrion
  • PMID:24361574 (2014): plastid plastid stroma
  • PMID:20061580 (2010): plastid plastid stroma
  • PMID:18633119 (2008): plastid plastid stroma
  • PMID:18431481 (2008): plastid plastid stroma
  • PMID:16207701 (2006): plastid
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : thiaminC
Curator
Summary (TAIR10)
Encodes a protein involved in thiamine biosynthesis. The protein is an iron-sulfur cluster protein predicted to catalyze the conversion of 5-aminoimidazole ribonucleotide (AIR) to hydroxymethylpyrimidine phosphate (HMP-P). A severe reduction of THIC levels in plants decreases vitamin B1 (thiamin diphosphate (TPP)) levels and also leads to changes in the levels of numerous other metabolites since so many primary metabolic enzymes require a TPP co-factor. thiC mutants are chlorotic and arrest in their development at the cotyledon stage. A N-terminal targeting sequence directs the THIC protein to the chloroplast stroma. The THIC transcript is regulated by a TPP riboswitch in the 3' UTR. THIC transcripts are observed in seedlings 5 or more days after germination, and light promotes the expression of this gene.
Computational
Description (TAIR10)
thiaminC (THIC); FUNCTIONS IN: iron-sulfur cluster binding, catalytic activity, ADP-ribose pyrophosphohydrolase activity; INVOLVED IN: response to vitamin B1, detection of bacterium, thiamin biosynthetic process; LOCATED IN: chloroplast, chloroplast stroma, plastid; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thiamine biosynthesis protein ThiC (InterPro:IPR002817); Has 4416 Blast hits to 4411 proteins in 1719 species: Archae - 238; Bacteria - 3466; Metazoa - 3; Fungi - 0; Plants - 61; Viruses - 0; Other Eukaryotes - 648 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:GQT-1951-MONOMERBioCyc:ARA:GQT-320-MONOMERBioCyc:MetaCyc:AT2G29630-MONOMERBioGrid:2863BRENDA:4.1.99.17EC:4.1.99.17eggNOG:COG0422
eggNOG:ENOG410IJHBEMBL:AC005496EMBL:AY092989EMBL:AY128756EMBL:CP002685EnsemblPlants:AT2G29630EnsemblPlants:AT2G29630.1
EnsemblPlants:AT2G29630.2EnsemblPlants:AT2G29630.3entrez:817513GeneID:817513Genevisible:O82392GO:GO:0009228GO:GO:0009229
GO:GO:0009507GO:GO:0009536GO:GO:0009570GO:GO:0010266GO:GO:0016829GO:GO:0046872GO:GO:0051536
GO:GO:0051539GO:GO:0080041Gramene:AT2G29630.1Gramene:AT2G29630.2Gramene:AT2G29630.3gramene_pathway:4.1.99.5gramene_pathway:THISYNARA-PWY
HAMAP:MF_00089hmmpanther:PTHR30557hmmpanther:PTHR30557:SF1HOGENOM:HOG000224484InParanoid:O82392InterPro:IPR002817KEGG:00730+4.1.99.17
KEGG:ath:AT2G29630KO:K03147OMA:HIIEKHCPaxDb:O82392PDB:4N7QPDB:4S25PDB:4S26
PDB:4S27PDB:4S28PDB:4S29PDBsum:4N7QPDBsum:4S25PDBsum:4S26PDBsum:4S27
PDBsum:4S28PDBsum:4S29Pfam:O82392Pfam:PF01964PhylomeDB:O82392PIR:F84698PRIDE:O82392
PRO:PR:O82392ProteinModelPortal:O82392Proteomes:UP000006548RefSeq:NP_001189634.1RefSeq:NP_180524.1RefSeq:NP_850135.1SMR:O82392
STRING:3702.AT2G29630.1TAIR:AT2G29630tair10-symbols:PYtair10-symbols:THICTIGRfam:TIGR00190TIGRFAMs:TIGR00190UniGene:At.24797
UniPathway:UPA00060UniProt:O82392
Coordinates (TAIR10) chr2:+:12667395..12669569
Molecular Weight (calculated) 71990.50 Da
IEP (calculated) 6.41
GRAVY (calculated) -0.41
Length 644 amino acids
Sequence (TAIR10)
(BLAST)
001: MAASVHCTLM SVVCNNKNHS ARPKLPNSSL LPGFDVVVQA AATRFKKETT TTRATLTFDP PTTNSERAKQ RKHTIDPSSP DFQPIPSFEE CFPKSTKEHK
101: EVVHEESGHV LKVPFRRVHL SGGEPAFDNY DTSGPQNVNA HIGLAKLRKE WIDRREKLGT PRYTQMYYAK QGIITEEMLY CATREKLDPE FVRSEVARGR
201: AIIPSNKKHL ELEPMIVGRK FLVKVNANIG NSAVASSIEE EVYKVQWATM WGADTIMDLS TGRHIHETRE WILRNSAVPV GTVPIYQALE KVDGIAENLN
301: WEVFRETLIE QAEQGVDYFT IHAGVLLRYI PLTAKRLTGI VSRGGSIHAK WCLAYHKENF AYEHWDDILD ICNQYDVALS IGDGLRPGSI YDANDTAQFA
401: ELLTQGELTR RAWEKDVQVM NEGPGHVPMH KIPENMQKQL EWCNEAPFYT LGPLTTDIAP GYDHITSAIG AANIGALGTA LLCYVTPKEH LGLPNRDDVK
501: AGVIAYKIAA HAADLAKQHP HAQAWDDALS KARFEFRWMD QFALSLDPMT AMSFHDETLP ADGAKVAHFC SMCGPKFCSM KITEDIRKYA EENGYGSAEE
601: AIRQGMDAMS EEFNIAKKTI SGEQHGEVGG EIYLPESYVK AAQK
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)