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AT2G19430.1
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
nucleus 1.000
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:28865150 (2017): extracellular region plant-type cell wall
  • PMID:24134884 (2013): cytoskeleton microtubules
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : DWD (DDB1-binding WD40 protein) hypersensitive to ABA 1
Curator
Summary (TAIR10)
This gene is predicted to encode a protein with a DWD motif. It can bind to DDB1a in Y2H assays, and DDB1b in co-IP assays, and may be involved in the formation of a CUL4-based E3 ubiquitin ligase. Encodes a component of the putative Arabidopsis THO/TREX complex: THO1 or HPR1 (At5g09860), THO2 (At1g24706), THO3 or TEX1 (At5g56130), THO5 (At5g42920, At1g45233), THO6 (At2g19430), and THO7 (At5g16790, At3g02950). THO/TREX complexes in animals have been implicated in the transport of mRNA precursors. Mutants of THO3/TEX1, THO1, THO6 accumulate reduced amount of small interfering (si)RNA, suggesting a role of the putative Arabidopsis THO/TREX in siRNA biosynthesis.
Computational
Description (TAIR10)
DWD (DDB1-binding WD40 protein) hypersensitive to ABA 1 (DWA1); CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40 repeat, conserved site (InterPro:IPR019775), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat (InterPro:IPR001680), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin/WD40 repeat-like superfamily protein (TAIR:AT3G49660.1); Has 25005 Blast hits to 14147 proteins in 619 species: Archae - 64; Bacteria - 4449; Metazoa - 9459; Fungi - 5655; Plants - 2500; Viruses - 0; Other Eukaryotes - 2878 (source: NCBI BLink).
Protein Annotations
BioGrid:1817eggNOG:ENOG410XTCDeggNOG:KOG0649EMBL:AC003058
EMBL:AC005917EMBL:AY099718EMBL:AY128879EMBL:CP002685
EnsemblPlants:AT2G19430EnsemblPlants:AT2G19430.1entrez:816462Gene3D:2.130.10.10
GeneID:816462Genevisible:Q8L4M1GO:GO:0000347GO:GO:0003723
GO:GO:0005634GO:GO:0006397GO:GO:0008380GO:GO:0009738
GO:GO:0009788GO:GO:0010267GO:GO:0016567GO:GO:0031047
GO:GO:0051028GO:GO:0080008Gramene:AT2G19430.1hmmpanther:PTHR22847
HOGENOM:HOG000005932InParanoid:Q8L4M1IntAct:Q8L4M1InterPro:IPR001680
InterPro:IPR015943InterPro:IPR017986InterPro:IPR019775KEGG:ath:AT2G19430
KO:K13175OMA:GRCVNQWPaxDb:Q8L4M1Pfam:PF00400
Pfam:Q8L4M1Pfscan:PS50082Pfscan:PS50294PhylomeDB:Q8L4M1
PIR:T01291PRIDE:Q8L4M1PRO:PR:Q8L4M1PROSITE:PS00678
PROSITE:PS50082PROSITE:PS50294ProteinModelPortal:Q8L4M1Proteomes:UP000006548
RefSeq:NP_849989.1scanprosite:PS00678SMART:SM00320SMR:Q8L4M1
STRING:3702.AT2G19430.1SUPFAM:SSF50978TAIR:AT2G19430tair10-symbols:AtTHO6
tair10-symbols:DWA1tair10-symbols:THO6UniGene:At.39844UniPathway:UPA00143
UniProt:Q8L4M1
Coordinates (TAIR10) chr2:+:8415217..8417740
Molecular Weight (calculated) 40075.30 Da
IEP (calculated) 5.58
GRAVY (calculated) -0.19
Length 367 amino acids
Sequence (TAIR10)
(BLAST)
001: MYGDATNWNE DEYRESILKE REIETRTVFR TAWAPPARIS NPDAFVVASS DGTLAFHSLN SLVSQSASFG YSKGQDVMVA EPERVVRAHE GPAYDVKFYG
101: EDEDALLLSC GDDGRVRGWK WREFAESDVS LHLKENHLKP LLELINPQHK GPWGALSPMP EINAMSVDPQ SGSVFTAAGD SCAYCWDVES GKIKMTFKGH
201: SDYLHTVVSR SSASQILTGS EDGTARIWDC KTGKCVKVIG SQDKKSRLRV SSMALDGSES WLVCGQGKNL ALWNLPASEC VQTIPIPAHV QDVMFDEKQI
301: LTVGAEPLLR RFDLNGALLS QIHCAPCSVF SISLHPAGVV AVGGYGGIVD VISQFGSHLC TFRSSSL
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)