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AT1G18500.1
Subcellular Consensus
(Prediction and Experimental)

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SUBAcon:
plastid 1.000
What is SUBAcon?
What is ASURE?
SUBAcon computations
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:26572690 (2016): extracellular region plant-type cell wall
  • PMID:25900983 (2015): Golgi Golgi apparatus Golgi membrane
  • PMID:25900983 (2015): Golgi trans-Golgi network
  • PMID:25900983 (2015): Golgi trans-Golgi network early endosome
  • PMID:25900983 (2015): Golgi trans-Golgi network multivesicular body
  • PMID:24872594 (2014): plastid plastid stroma
  • PMID:24361574 (2014): plastid plastid stroma
  • PMID:21531424 (2011): plastid
  • PMID:20423899 (2010): plastid
  • PMID:20061580 (2010): plastid plastid stroma
  • PMID:18431481 (2008): plastid plastid stroma
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : methylthioalkylmalate synthase-like 4
Curator
Summary (TAIR10)
Encodes an active Arabidopsis isopropylmalate synthase IPMS1. Involved in leucine biosynthesis. Do not participate in the chain elongation of glucosinolates. Expressed constitutively throughout the plant. Loss of IPMS1 can be compensated by a second isopropylmalate synthase gene IPMS2 (At1g74040).
Computational
Description (TAIR10)
methylthioalkylmalate synthase-like 4 (MAML-4); FUNCTIONS IN: 2-isopropylmalate synthase activity; INVOLVED IN: leucine biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), Alpha-isopropylmalate/homocitrate synthase, conserved site (InterPro:IPR002034), 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain (InterPro:IPR013709), Pyruvate carboxyltransferase (InterPro:IPR000891), Bacterial 2-isopropylmalate synthase (InterPro:IPR005671); BEST Arabidopsis thaliana protein match is: 2-isopropylmalate synthase 1 (TAIR:AT1G74040.1); Has 16947 Blast hits to 16939 proteins in 2437 species: Archae - 505; Bacteria - 8907; Metazoa - 233; Fungi - 482; Plants - 265; Viruses - 0; Other Eukaryotes - 6555 (source: NCBI BLink).
Protein Annotations
BioGrid:23670BRENDA:2.3.3.13EC:2.3.3.13eggNOG:COG0119eggNOG:KOG2367EMBL:AC013354EMBL:CP002684
EnsemblPlants:AT1G18500EnsemblPlants:AT1G18500.1entrez:838431Gene3D:3.20.20.70GeneID:838431Genevisible:Q9LPR4GO:GO:0003852
GO:GO:0009098GO:GO:0009507GO:GO:0009570Gramene:AT1G18500.1gramene_plant_reactome:1119540gramene_plant_reactome:6875186HAMAP:MF_01025
hmmpanther:PTHR10277hmmpanther:PTHR10277:SF42InParanoid:Q9LPR4InterPro:IPR000891InterPro:IPR002034InterPro:IPR005671InterPro:IPR013709
InterPro:IPR013785KEGG:00290+2.3.3.13KEGG:00620+2.3.3.13KEGG:ath:AT1G18500KO:K01649OMA:VMAITEDPaxDb:Q9LPR4
Pfam:PF00682Pfam:PF08502Pfam:Q9LPR4Pfscan:PS50991PhylomeDB:Q9LPR4PRIDE:Q9LPR4PRO:PR:Q9LPR4
PROSITE:PS00815PROSITE:PS50991ProteinModelPortal:Q9LPR4Proteomes:UP000006548RefSeq:NP_173285.2scanprosite:PS00815SMART:SM00917
SMR:Q9LPR4STRING:3702.AT1G18500.1SUPFAM:0043727SUPFAM:SSF110921SUPFAM:SSF51569TAIR:AT1G18500tair10-symbols:IPMS1
tair10-symbols:MAML-4TIGRfam:TIGR00973TIGRFAMs:TIGR00973UniGene:At.41792UniPathway:UPA00048UniProt:Q9LPR4
Coordinates (TAIR10) chr1:+:6369347..6372861
Molecular Weight (calculated) 68679.90 Da
IEP (calculated) 6.57
GRAVY (calculated) -0.23
Length 631 amino acids
Sequence (TAIR10)
(BLAST)
001: MASSLLRNPN LYSSTTITTT SFLPTFSSKP TPISSSFRFQ PSHHRSISLR SQTLRLSCSI SDPSPLPPHT PRRPRPEYIP NRISDPNYVR VFDTTLRDGE
101: QSPGATLTSK EKLDIARQLA KLGVDIIEAG FPAASKDDFE AVKTIAETVG NTVDENGYVP VICGLSRCNK KDIERAWDAV KYAKRPRIHT FIATSDIHLE
201: YKLKKTKAEV IEIARSMVRF ARSLGCEDVE FSPEDAGRSE REYLYEILGE VIKAGATTLN IPDTVGITLP SEFGQLITDL KANTPGIENV VISTHCQNDL
301: GLSTANTLSG AHAGARQMEV TINGIGERAG NASLEEVVMA IKCRGDHVLG GLFTGIDTRH IVMTSKMVEE YTGMQTQPHK AIVGANAFAH ESGIHQDGML
401: KHKGTYEIIC PEEIGLERSN DAGIVLGKLS GRHALKDRLT ELGYQLDDEQ LSTIFWRFKT VAEQKKRVTD ADIIALVSDE VFQPEAVWKL LDIQITCGTL
501: GLSTATVKLA DADGKEHVAC SIGTGPVDSA YKAVDLIVKE PATLLEYSMN AVTEGIDAIA TTRVLIRGSN KYSSTNAITG EEVQRTFSGT GAGMDIVVSS
601: VKAYVGALNK MMDFKENSAT KIPSQKNRVA A
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)